Active:
| 1. NIH/NIEHS, R01ES033345 03/16/2022 – 03/15/2027 |
Title: Per- and poly-fluoroalkyl substances (PFAS) in pregnancy vascular and placental dysfunction
Description: This project examines the molecular mechanistic link between environmental Perfluorooctane Sulfonic acid (PFOS) and gestational hypertension and fetal growth restriction. The proposed study could lead to the identification of new approaches and targets to prevent or treat preeclampsia.
Role: Principal Investigator
| 2. NIH/NICHD, R01 HD105699 06/01/2021 – 05/31/2024 |
Title: H2S and Uterine Vasodilation in Pregnancy and Preeclampsia
Description: This study determines the physiological role of the hydrogen sulfide (H2S) in the maternal uterine artery and systemic vascular adaptations to pregnancy by examining the vasodilatory mechanisms in normal pregnancy and how this gets impaired in preeclamptic pregnancies.
Role: Principal Investigator-subcontract (Muti-PI: D Chen, University of California, Irvine)
| 3. NIH/NHLBI, R01 HL134779 08/15/2017– 08/14/2022 |
Title: Vascular AT2R expression and function during pregnancy
Description: This proposal aims to determine the molecular mechanisms that regulate the vascular expression of angiotensin type 2 receptor (AT2R) during pregnancy and examine the therapeutic potential of AT2R agonists in combating preeclampsia.
Role: Principal Investigator
| 4. ICTR-UWHC 10/01/2021 – 09/30/2022 |
Title: Per- and polyfluoroalkyl substances (PFAS) and hypertensive disorders of pregnancy
Description: This application aims to identify the most predominant PFAS in pregnant women with preeclampsia, fetal growth restriction, and gestational diabetes and use animal models to elucidate the pathophysiological mechanisms.
Role: Principal Investigator