Kumar Lab

FUNDING

Active:

  1. NIH/NHLBI, R01 HL119869, 07/01/2013 – 06/30/2018

        Sex-Specific Fetal Programming of Adult Vascular Dysfunction and                                 Hypertension

The proposed studies, focusing on a molecular mechanistic link between adverse intrauterine environments and development of a hypertensive phenotype, will provide direct evidence that elevated androgen levels during pregnancy increases the risk of hypertension and cardiovascular disease in the offspring. This new evidence will provide several possible sex-specific approaches to improving vascular function and reducing high blood pressure. Role: Principal Investigator

  1. NIH/NHLBI, R01 HL134779, 08/15/17– 08/14/21

        Vascular AT2R expression and function during pregnancy

The goal of this proposal is to examine molecular mechanism of vascular angiotensin type 2 receptor (AT2R) upregulation and its importance in normal pregnancy associated vascular function. Studies will also examine if activation of this receptor system can reverse preeclamptic vascular dysfunction and hypertension. The proposed study could lead to identification of targets to treat or prevent preeclampsia. Role: Principal Investigator

Pending:

  1. NIH/NICHD, R01 HD096211, 07/01/2018 – 06/30/2020

        Hydrogen Sulfide and Maternal Adaptation to Pregnancy

In this study, Dr. Chen (University of California, Irvine, CA) proposes to determine the physiological role of the CBS-H2S pathway in maternal uterine artery and systemic vascular adaptations to pregnancy.  My role is to perform vascular studies and blood pressure measurements in rat model (aims 2 and 4). In this R01 grant the subcontract is for first 2 years. I provided all preliminary data pertaining to aim 2 and 4. All the proposed subcontract grant funds are to my research group. Role: Principal Investigator on the subcontract

Completed:

  1. NIH/NICHD, R03 HD069750, 07/01/11– 06/30/14

        Maternal Androgen Excess: Vascular and Placental Function and Fetal                             Consequences

The main goal of this project were to examine the effect of elevated maternal testosterone levels on maternal cardiovascular adaptations to pregnancy and placental angiogenesis and nutrient transport capacity. Role: Principal Investigator

  1. NIH/NHLBI, HL102866, 12/01/2010– 11/30/2014

        Developmental Programming: Influence of Sex Steroids and                                            Mechanisms

This project assessed the mechanisms underlying the developmental programming of adult health and disease and the influence of sex steroid hormones. Role: Co-Investigator

  1. NIH/NHLBI, HL058144-13S1, 6/30/2011– 05/31/2013

        Sex Steroid Hormones and Calcitonin Gene-related Peptide

The goal of this supplement was to determine the importance of calcitonin gene-related peptide family peptides in maternal vascular and placental functions. Role: Co-Investigator

  1. NIH/NHLBI, HL058144, 7/1/2013– 05/31/2017

        Sex Steroid Hormones and Calcitonin Gene-Related Peptide

The goal was to define the role of calcitonin gene-related peptide family peptides in the regulation of female vascular functions, and to examine their involvement of these peptides in uteroplacental function. Role: Co-Investigator