Kumar Lab



1. NIH/NIEHS, R01ES033345                                                  03/16/2022 – 03/15/2027

Title: Per- and poly-fluoroalkyl substances (PFAS) in pregnancy vascular and placental dysfunction

Description: This project examines the molecular mechanistic link between environmental Perfluorooctane Sulfonic acid (PFOS) and gestational hypertension and fetal growth restriction. The proposed study could lead to the identification of new approaches and targets to prevent or treat preeclampsia.

Role: Principal Investigator

2. NIH/NICHD, R01 HD105699                                                06/01/2021 – 05/31/2024

Title: H2S and Uterine Vasodilation in Pregnancy and Preeclampsia

Description: This study determines the physiological role of the hydrogen sulfide (H2S) in the maternal uterine artery and systemic vascular adaptations to pregnancy by examining the vasodilatory mechanisms in normal pregnancy and how this gets impaired in preeclamptic pregnancies.

Role: Principal Investigator-subcontract (Muti-PI: D Chen, University of California, Irvine)

3. NIH/NHLBI, R01 HL134779                                                  08/15/2017– 08/14/2022

Title: Vascular AT2R expression and function during pregnancy

Description: This proposal aims to determine the molecular mechanisms that regulate the vascular expression of angiotensin type 2 receptor (AT2R) during pregnancy and examine the therapeutic potential of AT2R agonists in combating preeclampsia.

Role: Principal Investigator

4. ICTR-UWHC                                                                        10/01/2021 – 09/30/2022

Title: Per- and polyfluoroalkyl substances (PFAS) and hypertensive disorders of pregnancy

Description: This application aims to identify the most predominant PFAS in pregnant women with preeclampsia, fetal growth restriction, and gestational diabetes and use animal models to elucidate the pathophysiological mechanisms.

Role: Principal Investigator