Kumar Lab

REPRESENTATIVE PUBLICATIONS

Click here for complete list

 

  1. Postnatal Cardiovascular Consequences in the Offspring of Pregnant Rats Exposed to Smoking and Smoking Cessation Pharmacotherapies. Gopalakrishnan K, More AS, Hankins GD, Nanovskaya TN, Kumar S. Reproductive sciences (Thousand Oaks, Calif.). 2017; 24(6):919-933. PMID: 27733658
  2. Hyperandrogenemia reduces endothelium-derived hyperpolarizing factor-mediated relaxation in mesenteric artery of female rats. Mishra JS, More AS, Hankins GDV, Kumar S. Biology of reproduction. 2017; 96(6):1221-1230. PMID: 28486649
  3. Testosterone downregulates angiotensin II type-2 receptor via androgen receptor-mediated ERK1/2 MAP kinase pathway in rat aorta. Mishra JS, Hankins GD, Kumar S. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2016; 17(4). PMID: 27765882
  4. Prenatal Testosterone Exposure Decreases Aldosterone Production but Maintains Normal Plasma Volume and Increases Blood Pressure in Adult Female Rats. More AS, Mishra JS, Hankins GD, Kumar S. Biology of reproduction. 2016; 95(2):42. PMID: 27385784
  5. Elevated Testosterone Reduces Uterine Blood Flow, Spiral Artery Elongation, and Placental Oxygenation in Pregnant Rats. Gopalakrishnan K, Mishra JS, Chinnathambi V, Vincent KL, Patrikeev I, Motamedi M, Saade GR, Hankins GD, Sathishkumar K. Hypertension (Dallas, Tex. : 1979). 2016; 67(3):630-9. PMID: 26781277
  6. Prenatal Testosterone Exposure Leads to Gonadal Hormone-Dependent Hyperinsulinemia and Gonadal Hormone-Independent Glucose Intolerance in Adult Male Rat Offspring. More AS, Mishra JS, Gopalakrishnan K, Blesson CS, Hankins GD, Sathishkumar K. Biology of reproduction. 2016; 94(1):5. PMID: 26586841
  7. Enalapril Normalizes Endothelium-Derived Hyperpolarizing Factor-Mediated Relaxation in Mesenteric Artery of Adult Hypertensive Rats Prenatally Exposed to Testosterone. More AS, Mishra JS, Hankins GD, Yallampalli C, Sathishkumar K. Biology of reproduction. 2015; 92(6):155. PMID: 25972013
  8. Prenatal testosterone exposure induces hypertension in adult females via androgen receptor-dependent protein kinase Cδ-mediated mechanism. Blesson CS, Chinnathambi V, Hankins GD, Yallampalli C, Sathishkumar K. Hypertension (Dallas, Tex. : 1979). 2015; 65(3):683-690. PMID: 25489059
  9. Enhanced mesenteric arterial responsiveness to angiotensin II is androgen receptor-dependent in prenatally protein-restricted adult female rat offspring. Sathishkumar K, Balakrishnan MP, Yallampalli C. Biology of reproduction. 2015; 92(2):55. PMID: 25550341
  10. Elevated testosterone levels during rat pregnancy cause hypersensitivity to angiotensin II and attenuation of endothelium-dependent vasodilation in uterine arteries. Chinnathambi V, Blesson CS, Vincent KL, Saade GR, Hankins GD, Yallampalli C, Sathishkumar K. Hypertension (Dallas, Tex. : 1979). 2014; 64(2):405-14. PMID: 24842922
  11. Gestational exposure to elevated testosterone levels induces hypertension via heightened vascular angiotensin II type 1 receptor signaling in rats. Chinnathambi V, More AS, Hankins GD, Yallampalli C, Sathishkumar K. Biology of reproduction. 2014; 91(1):6. PMID: 24855104
  12. Prenatal testosterone induces sex-specific dysfunction in endothelium-dependent relaxation pathways in adult male and female rats. Chinnathambi V, Yallampalli C, Sathishkumar K. Biology of reproduction. 2013; 89(4):97. PMID: 23966325
  13. Calcitonin gene-related family peptides in vascular adaptations, uteroplacental circulation, and fetal growth. Yallampalli C, Chauhan M, Sathishkumar K. Current vascular pharmacology. 2013; 11(5):641-54. PMID: 24063381
  14. Testosterone alters maternal vascular adaptations: role of the endothelial NO system. Chinnathambi V, Balakrishnan M, Ramadoss J, Yallampalli C, Sathishkumar K. Hypertension (Dallas, Tex. : 1979). 2013; 61(3):647-54. PMID: 23339170
  15. Temporal alterations in vascular angiotensin receptors and vasomotor responses in offspring of protein-restricted rat dams. Sathishkumar K, Balakrishnan M, Chinnathambi V, Gao H, Yallampalli C. American journal of obstetrics and gynecology. 2012; 206(6):507.e1-10. PMID: 22537420
  16. Fetal sex-related dysregulation in testosterone production and their receptor expression in the human placenta with preeclampsia. Sathishkumar K, Balakrishnan M, Chinnathambi V, Chauhan M, Hankins GD, Yallampalli C. Journal of perinatology : official journal of the California Perinatal Association. 2012; 32(5):328-35. PMID: 21904298
  17. Prenatal testosterone exposure leads to hypertension that is gonadal hormone-dependent in adult rat male and female offspring. Chinnathambi V, Balakrishnan M, Yallampalli C, Sathishkumar K. Biology of reproduction. 2012; 86(5):137, 1-7. PMID: 22302690
  18. Protein restriction during pregnancy induces hypertension in adult female rat offspring–influence of oestradiol. Sathishkumar K, Elkins R, Yallampalli U, Yallampalli C. The British journal of nutrition. 2012; 107(5):665-73. PMID: 21787449
  19. Prenatal testosterone-induced fetal growth restriction is associated with down-regulation of rat placental amino acid transport. Sathishkumar K, Elkins R, Chinnathambi V, Gao H, Hankins GD, Yallampalli C. Reproductive biology and endocrinology : RB&E. 2011; 9:110. PMID: 21812961
  20. Fetal programming of adult hypertension in female rat offspring exposed to androgens in utero. Sathishkumar K, Elkins R, Yallampalli U, Balakrishnan M, Yallampalli C. Early human development. 2011; 87(6):407-14. PMID: 21450421
  21. Raf-1 kinase regulates smooth muscle contraction in the rat mesenteric arteries. Sathishkumar K, Yallampalli U, Elkins R, Yallampalli C. Journal of vascular research. 2010; 47(5):384-98. PMID: 20110729
  22. Simultaneous analysis of expression of multiple redox-sensitive and apoptotic genes in hypothalamic neurons exposed to cholesterol secoaldehyde. Sathishkumar K, Raghavamenon AC, Ganeshkumar K, Telaprolu R, Parinandi NL, Uppu RM. Methods in molecular biology (Clifton, N.J.). 2010; 610:263-84. PMID: 20013184
  23. Determination of glutathione, mitochondrial transmembrane potential, and cytotoxicity in H9c2 cardiomyoblasts exposed to reactive oxygen and nitrogen species. Sathishkumar K, Gao X, Raghavamenon AC, Murthy SN, Kadowitz PJ, Uppu RM. Methods in molecular biology (Clifton, N.J.). 2010; 610:51-61. PMID: 20013172
  24. Cholesterol secoaldehyde induces apoptosis in H9c2 cardiomyoblasts through reactive oxygen species involving mitochondrial and death receptor pathways. Sathishkumar K, Gao X, Raghavamenon AC, Parinandi N, Pryor WA, Uppu RM. Free radical biology & medicine. 2009; 47(5):548-58. PMID: 19477266
  25. Protein restriction during pregnancy induces hypertension and impairs endothelium-dependent vascular function in adult female offspring. Sathishkumar K, Elkins R, Yallampalli U, Yallampalli C. Journal of vascular research. 2009; 46(3):229-39. PMID: 18957856
  26. Cholesterol secoaldehyde, an ozonation product of cholesterol, induces amyloid aggregation and apoptosis in murine GT1-7 hypothalamic neurons. Sathishkumar K, Xi X, Martin R, Uppu RM. Journal of Alzheimer’s disease : JAD. 2007; 11(3):261-74. PMID: 17851176
  27. Methyl vinyl ketone induces apoptosis in murine GT1-7 hypothalamic neurons through glutathione depletion and the generation of reactive oxygen species. Sathishkumar K, Rangan V, Gao X, Uppu RM. Free radical research. 2007; 41(4):469-77. PMID: 17454129
  28. Cytotoxic effects of oxysterols produced during ozonolysis of cholesterol in murine GT1-7 hypothalamic neurons. Sathishkumar K, Murthy SN, Uppu RM. Free radical research. 2007; 41(1):82-8. PMID: 17164181
  29. Relative contribution of intracellular and extracellular Ca2+ to alpha2-adrenoceptor-mediated contractions of ovine pulmonary artery. Sathishkumar K, Ross GR, Prakash VR, Mishra SK. Pharmacological research. 2006; 54(3):219-25. PMID: 16787748
  30. A major ozonation product of cholesterol, 3beta-hydroxy-5-oxo-5,6-secocholestan-6-al, induces apoptosis in H9c2 cardiomyoblasts. Sathishkumar K, Haque M, Perumal TE, Francis J, Uppu RM. FEBS letters. 2005; 579(28):6444-50. PMID: 16288747
  31. Segmental heterogeneity in the mechanism of sodium nitroprusside-induced relaxation in ovine pulmonary artery. Sathishkumar K, Ross RG, Bawankule DU, Sardar KK, Prakash VR, Mishra SK. Journal of cardiovascular pharmacology. 2005; 45(6):491-8. PMID: 15897774
  32. Mechanisms of lipopolysaccharide-induced changes in effects of contractile agonists on pregnant rat myometrium. Ross RG, Sathishkumar K, Naik AK, Bawankule DU, Sarkar SN, Mishra SK, Prakash VR. American journal of obstetrics and gynecology. 2004; 190(2):532-40. PMID: 14981402