Kumar Lab

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Our research focus is on endocrine hormones that alter cardiovascular and placental function. We use an integrated approach that combines basic science, molecular laboratory techniques, and state-of-the-art cardiovascular tools to study:

  • How hormones regulate cardiovascular and placental function
  • How altered endocrine environment during pregnancy sets up the fetus to develop hypertension and diabetes during their adult life
  • How hormones differentially regulate cardiovascular and metabolic function in males and females

We take a lifespan approach to our research investigations in that we believe that window of opportunity for investigation of sex differences in disease occur when the heart and body are differentially exposed to changes in hormonal status, such as during fetal development, puberty, pregnancy, and perimenopause and menopause. We investigate the fetal and neonatal programming of sex differences in adult onset cardiovascular and metabolic disorders focusing on the roles of adrenal and gonadal hormones, genes, and inflammatory factors. We believe that an understanding of these hormonal and genetic pathways will provide knowledge for the development of sex-specific drug discovery and other treatments for these disorders