Lipinski Lab

Publications

Sun MR, AC Steward, EA Sweet, AA Martin, and RJ Lipinski.  Developmental malformations resulting from high-dose maternal tamoxifen exposure in the mousePLOS ONE.

Curtis SW, D Chang, MR Sun, MP Epstein, JC Murray, E Feingold, TH Beaty, SM Weinberg, ML Marazita, RJ Lipinski, JC Carlson, and EJ Leslie.  FAT4 identified as a potential modifier of orofacial cleft lateralityGenet Epidemiol. 2021 Jun 15

Johnson BP, RA Vitek, MM Morgan, DM Fink, TG Beames, PG Geiger, DJ Beebe, and RJ Lipinski. A microphysiological approach to evaluate effectors of intercellular Hedgehog signaling in development. Frontiers in Cell and Developmental Biology. 2021 Feb 9;9:621442. doi: 10.3389/fcell.2021.621442.

Addissie YA, A Troia, ZC Wong, JL Everson, BA Kozel, M Muenke, RJ Lipinski, KMC Malecki, and P Kruszka (2021). Identifying environmental risk factors and gene-environment interactions in holoprosencephaly. Birth Defects Research. 2021 Jan 1;113(1):63-76. doi: 10.1002/bdr2.1834.

Rivera-Gonzalez KS, TG Beames, and RJ Lipinski (2021). Evaluating the developmental toxicity of piperonyl butoxide as a Sonic hedgehog pathway inhibitor. Chemosphere. 2021 Feb;264(Pt 1):128414. doi: 10.1016/j.chemosphere.2020.128414.

Sun MR, HM Chung, V Matsuk, DM Fink, MJ Stebbins, SP Palacek, EV Shusta, and RJ Lipinski (2020). Sonic hedgehog signaling in cranial neural crest cells regulates microvascular morphogenesis in facial development. Frontiers in Cell and Developmental Biology.  Oct 7;8:590539. doi: 10.3389/fcell.2020.590539

Beames TG and RJ Lipinski (2020). Gene-environment interactions: aligning birth defects research with complex etiology. Development. Jul 17;147(21):dev191064. doi: 10.1242/dev.191064.

Addissie YA, P Kruszka, A Trioia, Z Wong, JL Everson, BA Kozel, RJ Lipinski, KMC Malecki, M Muenke (2020). Prenatal Exposure to Pesticides and Risk for Holoprosencephaly: A Case-Control Study.  Environmental Health. Jun 8;19(1):65. doi: 10.1186/s12940-020-00611-z

Bishop M, KD Perez, M Sun, S Ho, P Chopra, N Mukhopadhyay, JB Hetmanski, MA Taub, LM Moreno-Uribe, LC Valencia-Ramirez, CP Restrepo Muñeton, G Wehby, JT Hecht, F Deleyiannis, SM Weinberg, YH Wu-Chou, PK Chen, H Brand, MP Epstein, I Ruczinski, JC Murray, TH Beaty, E Feingold, RJ Lipinski, DJ Cutler, ML Marazita, EJ Leslie (2020). Genome-wide enrichment of de novo coding mutations in orofacial cleft trios. American Journal of Human Genetics.  Jul 2;107(1):124-136. doi: 10.1016/j.ajhg.2020.05.018.

Hughes J, E Alkhunaizi, P Kruszka, L Pyle, D Grange, SI Berger, K Payne, D Masser-Frye, T Hu, M Christie, N Clegg, JL Everson, AF Martinez, L Walsh, M Jones, K Riedhammer, RJ Lipinski, CM Vezina, M Muenke, and D Chitayat (2020). Loss of Function Variants in PPP1R12A Cause Holoprosencephaly Spectrum and Urogenital Malformations. American Journal of Human Genetics.  Jan 2;106(1):121-128.

Everson JL, MR Sun, DM Fink, GW Heyne, CG Melberg, KF Nelson, P Doroodchi, LJ Colopy, CM Ulschmid, AA Martin, MT McLaughlin, and RJ Lipinski (2019). Developmental toxicity assessment of piperonyl butoxide exposure targeting Sonic hedgehog signaling and forebrain and face morphogenesis in the mouse: an in vitro and in vivo. Environmental Health Perspectives.127(10):107006

Kruszka P, SI Berger, V Casa, MR Dekker, J Gaesser, K Weiss, AF Martinez, DR Murdock, RJ Louie, EJ Prijoles, AW Lichty, OF Brouwer, E Zonneveld-Huijssoon, MJ Stephan, J Hogue, P Hu, M Tanima-Nagai, JL Everson, C Prasad, A Cereda, M Iascone, A Schreiber, V Zurcher, N Corsten-Janssen, L Escobar, NJ Clegg, MR Delgado, O Hajirnis, M Balasubramanian, H Kayserili, M Deardorff, RA Poot, KS Wendt, RJ Lipinski, and M Muenke (2019). Cohesin complex-associated holoprosencephaly. Brain. 142(9):2631-2643.

Grinblat, Y and RJ Lipinski (2019). A forebrain undivided: Unleashing model organisms to solve the mysteries of holoprosencephaly. Developmental Dynamics. 248(8):626-633

Kruszka P, SI Berger, K Weiss , JL Everson, AF Martinez, S Hong, K Anyane-Yeboa, Lipinski RJ, and M Muenke (2019). A CCR4-NOT Transcription Complex, Subunit 1, CNOT1, Variant Associated with Holoprosencephaly. American Journal of Human Genetics. 104(5):990-993

Everson, JLG, DM Fink, HM Chung, MR Sun, and RJ Lipinski (2018). Identification of Sonic Hedgehog regulated genes and biological processes in the cranial neural crest mesenchyme by comparative transcriptomics. BMC Genomics. 27;19(1):497.

Ansen-Wilson LJ, JL Everson, DM Fink, HW Kietzman, R Sullivan and RJ Lipinski. (2018).  Common basis for orofacial clefting and cortical interneuronopathyTranslational Psychiatry. 10;8(1):8

Fink DM, MR Sun, GW Heyne, JL Everson, HM Chung, S Park, MD Sheets and RJ Lipinski (2018). Coordinated D-Cyclin/Foxd1 activation drives mitogenic activity of Sonic Hedgehog signaling pathway.  Cellular Signalling.  44:1-9

Guillen-Sacoto MJ, Martinez AF, Abe Y, Kruszka P, Weiss K, Everson JL, Bataller R, Kleiner DE, Ward JM, Sulik KK, Lipinski RJ, Solomon BD, Muenke M (2017).  Human germline hedgehog pathway mutations predispose to fatty liver. J Hepatol. 67(4):809-817.

Everson JL, DM Fink, JW Yoon, EJ Leslie, HW Keitzman, LJ Ansen-Wilson, HM Chung, DO Walterhouse, ML Marazita, RJ Lipinski  (2017). Sonic Hedgehog regulation of Foxf2 promotes cranial neural crest mesenchyme proliferation and is disrupted in cleft lip morphogenesis. Development. 144(11):2082-2091.

Ansen-Wilson LJ, Lipinski RJ (2016).  Gene-environment interactions in cortical interneuron development and dysfunction: A review of preclinical studies.  Neurotoxicology. 58:120-129.

Heyne, GW, JL Everson, LJ Ansen-Wilson, CG Melberg, DM Fink, KF Parins, P Doroodchi, CM Ulschmid, and RJ Lipinski (2016).  Gli2 gene-environment interactions contribute to the etiological complexity of holoprosencephaly: evidence from a mouse model.  Disease Models and Mechanisms. 9(11):1307-1315.

Heyne GW, EH Plisch, CG Melberg, EP Sandgren, JA Peter, RJ Lipinski (2015). A simple and reliable method for early pregnancy detection in inbred mice. Journal of the American Association for Laboratory Animal Science. 54(4):368-71.

Heyne, GW, CG Melberg, P Doroodchi, KF Parins, HW Kietzman, JL Everson, LJ Ansen-Wilson, and RJ Lipinski (2015). Definition of critical periods for Hedgehog pathway antagonist-induced holoprosencephaly, cleft lip, and cleft palate. PLOS ONE. 10(3):e0120517.

Laporta J, Keil KP, Weaver SR, Cronick CM, Prichard AP, Crenshaw TD, Heyne GW, Vezina CM, Lipinski RJ, Hernandez LL, (2014). Serotonin regulates calcium homeostasis in lactation by epigenetic activation of Hedgehog signaling. Mol. Endocrinol.  28(11):1866-74.