Lipinski Lab


The focus of our research is to understand how genetic and environmental factors interact to cause birth defects of the face and brain. We are particularly interested in craniofacial malformations like cleft lip and palate and holoprosencephaly because of their prevalence and serious consequences for affected individuals and their families. Effective prevention strategies for these birth defects are not available because our understanding of how they are caused is inadequate.  We use in vitro and in vivo animal model systems that recapitulate normal and abnormal development to identify and characterize genetic and environmental factors that interact to cause these birth defects.