Lipinski Lab


Our mission is to solve the gene-environment puzzle to prevent birth defects. Birth defects affect more than 5 million newborns around the world each year.  Development of targeted birth defect prevention strategies has been stymied by biological and etiological complexity.  In fact, an estimated 75% are caused by the interaction of multiple, yet-to-be-identified predisposing genetic mutations and environmental influences. We have developed in vivo and advanced in vitro models that recapitulate molecular, cellular, and morphological aspects of human embryogenesis to identify genetic and environmental birth defect risk factors.  Our mission is to generate knowledge that contributes to the development of birth defects prevention strategies.