Affecting millions of newborns each year, birth defects profoundly impact individuals, families, and communities. The focus of our research group is to better understand human birth defects, dissect their complex causes, and apply this knowledge to the development of prevention strategies.
We are resolving the gene-environment puzzle to develop birth defect prevention strategies
Developmental toxicity assessment of piperonyl butoxide exposure targeting Sonic hedgehog signaling and forebrain and face morphogenesis in the mouse: an in vitro and in vivo. Environmental Health Perspectives.
Prenatal Exposure to Pesticides and Risk for Holoprosencephaly: A Case-Control Study. Environmental Health.
We are developing new models and identifying novel mechanisms of human birth defects
A microphysiological approach to evaluate effectors of intercellular Hedgehog signaling in development. Frontiers in Cell and Developmental Biology.
Sonic Hedgehog Signaling in Cranial Neural Crest Cells Regulates Microvascular Morphogenesis in Facial Development. Frontiers in Cell and Developmental Biology.
Common basis for orofacial clefting and cortical interneuronopathy. Translational Psychiatry.
We are identifying human disease genes and defining their function in development
Genome-wide enrichment of de novo coding mutations in orofacial cleft trios. American Journal of Human Genetics.
Loss of Function Variants in PPP1R12A Cause Holoprosencephaly Spectrum and Urogenital Malformations. American Journal of Human Genetics.
We are elucidating cellular signaling pathways that drive embryonic development