Titles and Education
- Diplomate, American College of Veterinary Surgeons, 1988
- BS 1981, University of California
- DVM 1983, University of California
- PhD 1990, Mayo Graduate School of Medicine
Research
Regeneration of musculoskeletal tissues, including enhancement of fracture healing; cartilage resurfacing techniques; tendon healing and regeneration, development of long bone fracture repair methods, and integrating peripheral nerves with robotic prosthetics. The Comparative Orthopaedic Research Laboratory is a multi-investigator group that focuses on bone, tendon, cartilage, and joint injury, neural regeneration, inflammation and repair.
Responsibilities
Dean, School of Veterinary Medicine
Vilas Distinguished Achievement Professor
Co-Director, Comparative Orthopaedic Research Laboratory
Clinical Interests
Large animal surgery, specializing in orthopedics.
Graduate Training
I co-direct the Comparative Orthopaedic Research Laboratory where we focus on the regeneration of musculoskeletal tissues, including tendon, cartilage and bone.This work is comparative in nature and meant to benefit animals and humans. I no longer have training opportunities available for graduate students.
Recent Publications
1. Lu Y, Lee JS, Nemke B, Graf BK, Royalty K, Illgen III R, Vanderby Jr R, Markel MD, Murphy WL: Coating with a modular bone morphogenetic peptide promotes healing of a bone-implant gap in an ovine model. PLoS ONE 2012;7(11):e50378. doi:10.1371/journal.pone.0050378. Epub 2012 Nov 21.
2. Suárez-González D, Lee JS, Diggs A, Lu Y, Nemke B, Markel M, Hollister SJ, Murphy WL: Controlled multiple growth factor delivery from bone tissue engineering scaffolds via designed affinity.Tissue Eng Part A 2014 Aug;20(15-16):2077-87. doi: 10.1089/ten.tea.2013.0358. Epub 2013 Dec 18.
3. Bleedorn JA, Sullivan R, Lu Y, Kalscheur V, Markel MD: Percutaneous lovastatin accelerates bone healing but is associated with periosseous soft tissue inflammation in a canine tibial osteotomy model. J Orthop Res 2014 Feb;32(2):210-6. doi: 10.1002/jor.22502. Epub 2013 Oct 25.
4. Dubois MS, Morello S, Rayment K, Markel MD, Vanderby R Jr, Kalscheur VL, Hao Z, McCabe RP, Marquis P, Muir P: Computed tomographic imaging of subchondral fatigue cracks in the distal end of the third metacarpal bone in the thoroughbred racehorse can predict crack micromotion in an ex-vivo model. PLos One 2014 Jul 31;9(7):e101230, doi: 10.1371/journal.pone.0101230. eCollection 2014.
5. Martin JA, Biedrzycki AH, Less KS, DeWall RJ, Brounts SH, Murphy WL, Markel MD, Thelen DG: In Vivo Measures of Shear Wave Speed as a Predictor of Tendon Elasticity and Strength.Ultrasound Med Biol 2015 Oct;41 (10):2722-30. doi: 10.1016/j.ultrasmedbio.2015.06.2008. Epub 2015 Jul 26.
6. Rowe-Guthrie KM, Markel MD, Bleedorn JA: Mechanical evaluation of locking, non-locking, and hybrid plating constructs using a locking compression plate in canine synthetic bone model. Vet Surg2015 Oct;44(7):838-42. doi: 10.1111/vsu.12368. Epub 2015 Aug 19.
7. Biedrzycki A, Markel MD, Brounts SH: Biomechanical evaluation of a novel subcuticular skin stapling device for use in equine abdominal surgeries. Vet Surg 2015 Feb;44(2):231-5. doi: 10.1111/j.1532-950X.2014.12245.x. Epub 2014 Jul 31.
8. Racette M, Al saleh H, Block WF, Waller KR 3rd, Bleedorn JA, McCabe RP, Vanderby R Jr, Markel MD, Brounts SH, Muir P: 3D FSE cube and VIPR-aTR 3.0 Tesla magnetic resonance imaging predicts canine cranial cruciate ligament structural properties. Vet J 2016 Mar;209:150-5. doi: 10.1016/j.tvjl.2015.10.055. Epub 2015 Nov 4.
9. Biedrzycki AH, Grand BD, Nemke B, Markel MD, Morello SL: Arthrodesis of the equine centrodistal and tarsometatarsal joints using a single modified kerf-cut cylinder. Vet Comp Orthop Traumatol 2016 May 18;29(3):227-31. doi: 10.3415/VCOT-15-10-0167. Epub 2016 Apr 12.
10. Biedrzycki AH, Grant BG, Nemke B, Morello SL, Markel MD: In vitro biomechanical evaluation of four surgical techniques for fusion of equine centrodistal and tarsometatarsal joints. Am J Vet Res2016 Oct;77(10): 1071-81. doi: 10.2460/ajvr.77.10.1071.
11. Rustom LE, Boudou T, Lou S, Pignot-Paintrand I, Nemke BW, Lu Y, Markel MD, Picart C, Wagoner Johnson AJ: Micropore-induced capillarity enhances bone distribution in vivo in biphasic calcium phosphate scaffolds. Acta Biomater 2016 Oct 15;44: 144-54. doi: 10.1016/j.actbio.2016.08.025. Epub 2016 Aug 17.
12. Yu X, Biedrzycki AH, Khalil AS, Hess D, Umhoefer JM, Markel MD, Murphy WL: Nanostructured mineral coatings stabilize proteins for therapeutic delivery. Adv Mater 2017 Jul 4. doi: 10.1002/adma.291701255.
13. Bleedorn JA, Hornberger TA, Goodman CA, Hao Z, Sample SJ, Amene E, Markel MD, Behan M, Muir P: Temporal mechanically-induced signaling events in bone and dorsal root ganglion neurons after in vivo bone loading. PLoS One 2018 Feb 27;13(2):e0192760: 10.1371/journal.pone.0192760.