Comparative Orthopaedic Research Laboratory

Key Publications

The following are our key publications in the last few years


Currently Updating


Use of a platelet-rich plasma-collagen scaffold as a bioenhanced repair treatment for management of partial cruciate ligament rupture in dogs. Sample SJ, Racette MA, Hans EC, Volstad NJ, Schaefer SL, Bleedorn JA, Little JP, Waller KR 3rd, Hao Z, Block WF, Muir P.  PLoS One. 2018 Jun 19;13(6):e0197204.

Multivariate genome-wide association analysis identifies novel and relevant variants associated with anterior cruciate ligament rupture risk in the dog model. Baker LA, Rosa GJM, Hao Z, Piazza A, Hoffman C, Binversie EE, Sample SJ, Muir P.  BMC Genet. 2018 Jun 26;19(1):39. doi: 10.1186/s12863-018-0626-7.

Effect of contact time on variance of ground reaction forces during force platform gait analysis of a heterogeneous sample of clinically normal dogs. Hoffman CL, Volstad NJ, Hans EC, Nemke BW, Muir P. Am J Vet Res. 2018 May;79(5):546-554.

Temporal mechanically-induced signaling events in bone and dorsal root ganglion neurons after in vivo bone loading. Bleedorn JA, Hornberger TA, Goodman CA, Hao Z, Sample SJ, Amene E, Markel MD, Behan M, Muir P. PLoS One. 2018 Feb 27;13(2):e0192760.


Genome-wide association analysis in dogs implicates 99 loci as risk variants for anterior cruciate ligament rupture. Baker LA, Kirkpatrick B, Rosa GJ, Gianola D, Valente B, Sumner JP, Baltzer W, Hao Z, Binversie EE, Volstad N, Piazza A, Sample SJ, Muir P.  PLoS One. 2017 Apr 5;12(4):e0173810. doi: 10.1371/journal.pone.0173810. PubMed PMID: 28379989; PubMed Central PMCID: PMC5381864.

Variance associated with walking velocity during force platform gait analysis of a heterogeneous sample of clinically normal dogs. Piazza AM, Binversie EE, Baker LA, Nemke B, Sample SJ, Muir P. Am J Vet Res. 2017 Apr;78(4):500-507.


Variance associated with the use of relative velocity for force platform gait analysis in a heterogeneous population of clinically normal dogs. Volstad N, Nemke B, Muir P. Vet J. 2015 Aug 13. pii: S1090-0233(15)00338-X. doi: 10.1016/j.tvjl.2015.08.014. [Epub ahead of print]

Mechanical Evaluation of Locking, Nonlocking, and Hybrid Plating Constructs Using a Locking Compression Plate in a Canine Synthetic Bone Model. Rowe-Guthrie KM, Markel MD, Bleedorn JA. Vet Surg. 2015 Oct;44(7):838-42. doi: 10.1111/vsu.12368. Epub 2015 Aug 19.

In Vivo Measures of Shear Wave Speed as a Predictor of Tendon Elasticity and Strength. Martin JA, Biedrzycki AH, Lee KS, DeWall RJ, Brounts SH, Murphy WL, Markel MD, Thelen DG. Ultrasound Med Biol. 2015 Oct;41(10):2722-30. doi: 10.1016/j.ultrasmedbio.2015.06.008. Epub 2015 Jul 26.

Biomechanical evaluation of a novel subcuticular skin stapling device for use in equine abdominal surgeries.Biedrzycki A, Markel MD, Brounts SH.Vet Surg. 2015 Feb;44(2):231-5. doi: 10.1111/j.1532-950X.2014.12245.x. Epub 2014 Jul 31.


Arthroscopic assessment of stifle synovitis in dogs with cranial cruciate ligament rupture. Little JP, Bleedorn JA, Sutherland BJ, Sullivan R, Kalscheur VL, Ramaker MA, Schaefer SL, Hao Z, Muir P. PLoS One. 2014 Jun 3;9(6):e97329. doi: 10.1371/journal.pone.0097329. eCollection 2014.

Computed tomographic imaging of subchondral fatigue cracks in the distal end of the third metacarpal bone in the thoroughbred racehorse can predict crack micromotion in an ex-vivo model. Dubois MS, Morello S, Rayment K, Markel MD, Vanderby R Jr, Kalscheur VL, Hao Z, McCabe RP, Marquis P, Muir P. PLoS One. 2014 Jul 31;9(7):e101230. doi: 10.1371/journal.pone.0101230. eCollection 2014.

Radiographic risk factors for contralateral rupture in dogs with unilateral cranial cruciate ligament rupture. Chuang C, Ramaker MA, Kaur S, Csomos RA, Kroner KT, Bleedorn JA, Schaefer SL, Muir P. PLoS One. 2014 Sep 25;9(9):e106389. doi: 10.1371/journal.pone.0106389. eCollection 2014.

Percutaneous lovastatin accelerates bone healing but is associated with periosseous soft tissue inflammation in a canine tibial osteotomy model. Bleedorn JA, Sullivan R, Lu Y, Nemke B, Kalscheur V, Markel MD. J Orthop Res. 2014 Feb;32(2):210-6. doi: 10.1002/jor.22502. Epub 2013 Oct 25.

Reproducibility and feasibility of acoustoelastography in the superficial digital flexor tendons of clinically normal horses. Ellison ME, Duenwald-Kuehl S, Forrest LJ, Vanderby R Jr, Brounts SH. Am J Vet Res. 2014 Jun;75(6):581-7. doi: 10.2460/ajvr.75.6.581.

Role of calcitonin gene-related peptide in functional adaptation of the skeleton. Sample SJ, Heaton CM, Behan M, Bleedorn JA, Racette MA, Hao Z, Muir P. PLoS One. 2014 Dec 23;9(12):e113959. doi: 10.1371/journal.pone.0113959. eCollection 2014.

Variance associated with subject velocity and trial repetition during force platform gait analysis in a heterogeneous population of clinically normal dogs.Hans EC, Zwarthoed B, Seliski J, Nemke B, Muir P. Vet J. 2014 Dec;202(3):498-502. doi: 10.1016/j.tvjl.2014.09.022. Epub 2014 Sep 28.