Comparative Orthopaedic Research Laboratory

Key Publications

The following are our key publications in the last few years


Pathologic classification of a late-onset peripheral neuropathy in a spontaneous Labrador retriever dog model. Anderson RS, Chu AK, Rylander H, Binversie EE, Duncan ID, Baker L, Salamat S, Patterson MM, Gruel J, Kohler NL, Kearney HK, Ale SM, Momen MM, Muir P, Svaren JP, Johnson R, Sample SJ. J Comp Neurol. 2024 Mar;532(3):e25596.

Injury prevention in Thoroughbred racehorses. Muir P, Whitton RC. Equine Vet J. 2024 May;56(3):386-388.

Subchondral bone fatigue injury in the parasagittal condylar grooves of the third metacarpal bone in thoroughbred racehorses elevates site-specific strain concentration. Irandoust S, Whitton RC, Muir P, Henak CR. J Mech Behav Biomed Mater. 2024 Apr 24;155:106561.


Genetic architecture and polygenic risk score prediction of degenerative suspensory ligament desmitis (DSLD) in the Peruvian Horse. Momen M, Brauer K, Patterson MM, Sample SJ, Binversie EE, Davis BW, Cothran EG, Rosa GJM, Brounts SH, Muir P. Front Genet. 2023 Aug 14;14:1201628.

Identification of genetic variants associated with anterior cruciate ligament rupture and AKC standard coat color in the Labrador Retriever. Lee BT, Baker LA, Momen M, Terhaar H, Binversie EE, Sample SJ, Muir P. BMC Genom Data. 2023 Oct 26;24(1):60.


Canine ACL rupture: a spontaneous large animal model of human ACL rupture. Binversie EE, Walczak BE, Cone SG, Baker LA, Scerpella TA, Muir P. BMC Musculoskeletal Disorders 2022; 23:116

Selection signature analyses and genome-wide association reveals genomic hotspot regions that reflect differences between breeds of horse with contrasting risk of degenerative suspensory ligament desmitis Momen M, Brounts SH, Binversie EE, Sample SJ, Rosa GJM, Davis BW, Muir P. . G3 (Bethesda). 2022 Jul 22:jkac179. doi: 10.1093/g3journal/jkac179. Epub ahead of print. PMID: 35866615.

Use of a novel helical fan beam imaging system for computed tomography of the distal limb in sedated standing horses: 167 cases (2019-2020) Brounts SH, Lund JR, Whitton RC, Ergun DL, Muir P.  J Am Vet Med Assoc. 2022 Jun 22;260(11):1351-1360. doi: 10.2460/javma.21.10.0439. PMID: 35943949.

Use of a novel helical fan beam imaging system for computed tomography of the head and neck in sedated standing horses: 120 cases (2019-2020) Brounts SH, Henry T, Lund JR, Whitton RC, Ergun DL, Muir P.  J Am Vet Med Assoc. 2022 Jun 22;260(11):1361-1368. doi: 10.2460/javma.21.10.0471. PMID: 35943950.


Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information. Momen M, Kohler NL, Binversie EE, Dentino M, Sample SJ. Canine Med Genet 2021; 8:9

Neurofilament light plasma concentration positively associates with age and negatively associates with weight and height in the dog. Perino J, Patterson M, Momen M,  Borisova M, Heslegrave A, Zetterberg H, Gruel J, Binversie EE, Baker LA, Svaren J, Sample SJ. Neuroscience Letters 2021; 744:135593

Biologically enhanced GWAS provides further evidence for candidate loci and discovers novel loci that influence risk of ACL rupture in the dog model. Baker LA, Momen M, McNally R, Berres M, Binversie EE, Sample SJ, Muir P.  Front Genetics 2021;12:593515.

Evaluation of outcomes following subtotal colectomy for the treatment of idiopathic megacolon in cats Grossman RM, Sumner JP, Lopez DJ, Dornbusch JA, Singh A, Lux CN, Sample SJ, Liptak JM, Grimes JA, Upchurch DA, Blumenthal MS, Traverson M, Buote NJ, Marvel SJ, Steffey MA, Arai S, Little JP, Atilla A, Huck JL, Pitt KA. J Am Vet Med Assoc. 2021 Nov 1;259(11):1292-1299. doi: 10.2460/javma.20.07.0418. PMID: 34727062.


Analysis of copy number variants in dogs implicates genomic structural variation in the development of anterior cruciate ligament rupture. Binversie EE, Engelman CD, Hao Z, Piazza AM, Sample SJ, Baker LA, Muir P.PLoS One 2020;15:e0244075

Bayesian and machine learning models for genomic prediction of anterior cruciate ligament rupture in the canine model. Baker LA, Momen M, Chan K, Bollig N, Lopes FB, Rosa GJM, Todhunter RJ, Binversie EE, Sample SJ, Muir P. G3 (Bethesda) 2020;10:2619-2628.

Contribution of Habitual Activity to Cruciate Ligament Rupture in Labrador Retrievers Terhaar HM, Muir P, Baker LA, Binversie EE, Chi J, Sample SJ. 2020 Mar;33(2):82-88. doi: 10.1055/s-0039-3399527. Epub 2020 Jan 8. PMID: 31914477; PMCID: PMC7085975.


Pro-inflammatory polarization of stifle synovial macrophages in dogs with cruciate ligament rupture. Yarnall BW, Chamberlain CS, Hao Z, Muir P.  Veterinary Surgery. 2019;48:1005-1012.

Genome-wide association studies and genetic testing: understanding the science, success, and future of a rapidly developing field Baker L, Muir P, Sample SJ. J Am Vet Med Assoc. 2019 Nov 15;255(10):1126-1136. doi: 10.2460/javma.255.10.1126. PMID: 31687891; PMCID: PMC6941202.


Use of a platelet-rich plasma-collagen scaffold as a bioenhanced repair treatment for management of partial cruciate ligament rupture in dogs. Sample SJ, Racette MA, Hans EC, Volstad NJ, Schaefer SL, Bleedorn JA, Little JP, Waller KR 3rd, Hao Z, Block WF, Muir P.  PLoS One. 2018 Jun 19;13(6):e0197204.

Multivariate genome-wide association analysis identifies novel and relevant variants associated with anterior cruciate ligament rupture risk in the dog model. Baker LA, Rosa GJM, Hao Z, Piazza A, Hoffman C, Binversie EE, Sample SJ, Muir P.  BMC Genet. 2018 Jun 26;19(1):39. doi: 10.1186/s12863-018-0626-7.

Effect of contact time on variance of ground reaction forces during force platform gait analysis of a heterogeneous sample of clinically normal dogs. Hoffman CL, Volstad NJ, Hans EC, Nemke BW, Muir P. Am J Vet Res. 2018 May;79(5):546-554.

Temporal mechanically-induced signaling events in bone and dorsal root ganglion neurons after in vivo bone loading. Bleedorn JA, Hornberger TA, Goodman CA, Hao Z, Sample SJ, Amene E, Markel MD, Behan M, Muir P. PLoS One. 2018 Feb 27;13(2):e0192760.


Genome-wide association analysis in dogs implicates 99 loci as risk variants for anterior cruciate ligament rupture. Baker LA, Kirkpatrick B, Rosa GJ, Gianola D, Valente B, Sumner JP, Baltzer W, Hao Z, Binversie EE, Volstad N, Piazza A, Sample SJ, Muir P.  PLoS One. 2017 Apr 5;12(4):e0173810. doi: 10.1371/journal.pone.0173810. PubMed PMID: 28379989; PubMed Central PMCID: PMC5381864.

Variance associated with walking velocity during force platform gait analysis of a heterogeneous sample of clinically normal dogs. Piazza AM, Binversie EE, Baker LA, Nemke B, Sample SJ, Muir P. Am J Vet Res. 2017 Apr;78(4):500-507.


Variance associated with the use of relative velocity for force platform gait analysis in a heterogeneous population of clinically normal dogs. Volstad N, Nemke B, Muir P. Vet J. 2015 Aug 13. pii: S1090-0233(15)00338-X. doi: 10.1016/j.tvjl.2015.08.014. [Epub ahead of print]

Mechanical Evaluation of Locking, Nonlocking, and Hybrid Plating Constructs Using a Locking Compression Plate in a Canine Synthetic Bone Model. Rowe-Guthrie KM, Markel MD, Bleedorn JA. Vet Surg. 2015 Oct;44(7):838-42. doi: 10.1111/vsu.12368. Epub 2015 Aug 19.

In Vivo Measures of Shear Wave Speed as a Predictor of Tendon Elasticity and Strength. Martin JA, Biedrzycki AH, Lee KS, DeWall RJ, Brounts SH, Murphy WL, Markel MD, Thelen DG. Ultrasound Med Biol. 2015 Oct;41(10):2722-30. doi: 10.1016/j.ultrasmedbio.2015.06.008. Epub 2015 Jul 26.

Biomechanical evaluation of a novel subcuticular skin stapling device for use in equine abdominal surgeries.Biedrzycki A, Markel MD, Brounts SH.Vet Surg. 2015 Feb;44(2):231-5. doi: 10.1111/j.1532-950X.2014.12245.x. Epub 2014 Jul 31.


Arthroscopic assessment of stifle synovitis in dogs with cranial cruciate ligament rupture. Little JP, Bleedorn JA, Sutherland BJ, Sullivan R, Kalscheur VL, Ramaker MA, Schaefer SL, Hao Z, Muir P. PLoS One. 2014 Jun 3;9(6):e97329. doi: 10.1371/journal.pone.0097329. eCollection 2014.

Computed tomographic imaging of subchondral fatigue cracks in the distal end of the third metacarpal bone in the thoroughbred racehorse can predict crack micromotion in an ex-vivo model. Dubois MS, Morello S, Rayment K, Markel MD, Vanderby R Jr, Kalscheur VL, Hao Z, McCabe RP, Marquis P, Muir P. PLoS One. 2014 Jul 31;9(7):e101230. doi: 10.1371/journal.pone.0101230. eCollection 2014.

Radiographic risk factors for contralateral rupture in dogs with unilateral cranial cruciate ligament rupture. Chuang C, Ramaker MA, Kaur S, Csomos RA, Kroner KT, Bleedorn JA, Schaefer SL, Muir P. PLoS One. 2014 Sep 25;9(9):e106389. doi: 10.1371/journal.pone.0106389. eCollection 2014.

Percutaneous lovastatin accelerates bone healing but is associated with periosseous soft tissue inflammation in a canine tibial osteotomy model. Bleedorn JA, Sullivan R, Lu Y, Nemke B, Kalscheur V, Markel MD. J Orthop Res. 2014 Feb;32(2):210-6. doi: 10.1002/jor.22502. Epub 2013 Oct 25.

Reproducibility and feasibility of acoustoelastography in the superficial digital flexor tendons of clinically normal horses. Ellison ME, Duenwald-Kuehl S, Forrest LJ, Vanderby R Jr, Brounts SH. Am J Vet Res. 2014 Jun;75(6):581-7. doi: 10.2460/ajvr.75.6.581.

Role of calcitonin gene-related peptide in functional adaptation of the skeleton. Sample SJ, Heaton CM, Behan M, Bleedorn JA, Racette MA, Hao Z, Muir P. PLoS One. 2014 Dec 23;9(12):e113959. doi: 10.1371/journal.pone.0113959. eCollection 2014.

Variance associated with subject velocity and trial repetition during force platform gait analysis in a heterogeneous population of clinically normal dogs.Hans EC, Zwarthoed B, Seliski J, Nemke B, Muir P. Vet J. 2014 Dec;202(3):498-502. doi: 10.1016/j.tvjl.2014.09.022. Epub 2014 Sep 28.