Timothy Yoshino


Department of Pathobiological Sciences

Timothy Yoshino

Titles and Education

  1. Professor of Parasitology
  2. Director, Cellular and Molecular Parasitology Training Program


RESEARCH AREAS: Physiological and molecular interactions between parasites and their invertebrate hosts; Comparative immunobiology; Invertebrate innate immunity; Invertebrate lectins as pathogen recognition receptors (PRR); Genomic, proteomic and glycomic profiling of larval schistosome development. DESCRIPTION: Research in the laboratory emphasizes the cellular, biochemical and molecular interactions between larval stages of the human blood fluke, Schistosoma mansoni , and its snail intermediate host, Biomphalaria glabrata. The major projects involve (1) investigating the recognition mechanisms underlying cellular immune responses to infection by larval S . mansoni in genetically defined susceptible and resistant snails, (2) recognition receptors of snail hemocytes (circulating phagocytic cells), with emphasis on lectin PRRs, larval glycans, and glycan-stimulated signal transduction systems, (3) characterizing differential gene- and protein expression changes during early larval schistosome development using microarray, SAGE, and proteomic analyses, and (4) glycomic analysis of complex carbohydrates expressed at the schistosome larval surface and investigating their role in host-parasite interactions. Supported by NIH grant RO1 AI15503.


Course Coordinator and Instructor, Veterinary Parasitology
Director and PI, NIH Cellular & Molecular Parasitology Training Program

Graduate Training

B.A., 1970 -  University of California, Santa Barbara (Zoology)
M.A., 1971 -  University of California, Santa Barbara (Biological Sciences-Parasitology)
Ph,D., 1975 - University of California, Santa Barbara (Biological Sciences-Parasitology/Immunology)
Postdoc, 1975-77 - Lehigh University, Bethlehem, PA (Comp Immunology/Tropical Diseases)

Recent Publications

  1. Yoshino TP, Wu XJ, Gonzalez LA, Hokke CH.  2013. Circulating Biomphalaria glabrata hemocyte subpopulations possess shared schistosome glycans and receptors capable of binding larval glycoconjugates.  Exp Parasitol 133:28-36. PMID: 23085445 
  2. Yoshino TP, Wu XJ, Liu H, Gonzalez LA, Deelder AM, Hokke CH (2012)  Glycotope sharing between snail hemolymph and larval schistosomes: Larval transformation products alter shared glycan patterns of plasma proteins.  PLoS Negl Trop Dis  6(3):e1569. PMCID: PMC3308936
  3. Yoshino, T P, Coustau C  (2011)  Immunobiology of Biomphalaria-Trematode Interactions. In “Biomphalaria Snails and Larval Trematodes” (R. Toledo, B. Fried, eds), Chapt. 7, pp. 159-189.  Springer, New York
  4. Yoshino TP, Dinguirard N, Mourão MM  (2010) In vitro manipulation of gene expression in larval Schistosoma: a model for postgenomic approaches in Trematoda. Parasitology 137:463-483. PMID: 19961646
  5. Wu XJ,  Sabat G,  Brown JF, Zhang M, Taft A, Peterson N, Harms A ,  Yoshino TP (2009)  Proteomic analysis of Schistosoma mansoni proteins released during in vitro miracidium-to-sporocyst transformation.  Mol. Biochem. Parasitol. 164:32-44. PMCID: PMC2665799