Department of Pathobiological Sciences
Titles and Education
- 1998-2002 Post doctoral training
University of Texas Southwestern Medical Center, Dallas, TX.
1998 Ph.D. Univeristy of Maryland School of Medicine, Baltimore, MD.
1990 M.V.Sc. Faculty of Veterinary Medicine, Cairo Univeristy, Egypt.
1986 B.V.Sc. Faculty of Veterinary Medicine, Cairo Univeristy, Egypt.
- Mycobacterial Pathogenesis
- Vaccine Development Against Human and Animal Infections.
- Evolution of Bacterial and Viral Genomes
The research in my laboratory involves developing new technologies and innovative approaches to understand bacterial pathogenesis and to generate useful therapies (drugs and vaccines) against human and animal infections. My research team developed novel approaches to address specific questions relevant to bacterial pathogenesis such as the identification of types of genes expressed during infection and the host responses to such gene products. Currently, we are working on the functional genomics of M. tuberculosis (M. tb) and M. avium subsp. paratuberculosis (M. ap). In particular, we are investigating questions related to the role of copper metabolism on M. tb persistence and the role played by key global gene regulators on M. ap survival during infection. We are also taking advantage of genetically modified organisms to develop more effective vaccines against tuberculosis (againt M. tb, M. bovis) and Johne’s disease.
Recently, we initiated a project to employ nanotechnology in developing vaccines and novel adjuvant systems against important poultry diseases (e.g. Avian Influenza, Infectious Bronchitis Virus and Infectious Bursal Disease). Our goal is to develop nanovaccines as a platform technology against diseases that threaten both the dairy and poultry industries.
- Inventor: Adel M. Talaat, Bassam Abomoelak and Sarah K. Ward. Immunogenic Compositions Against Tuberculosis. US 8,367,055 B2. (Issued)
- Inventor: Adel M. Talaat. Vaccine Candidates Against Johne’s Disease. US 8,758,773 (Issued)
- Inventor: Adel M. Talaat. Biomarkers for early diagnosis and differentiation of mycobacterial infection. WARF: P130075US01 (Pending)
- Inventor: Adel M. Talaat. Global gene regulators (GGR) as vaccine candidates against paratuberculosis. US 20140271719 (Pending)
Responsibilities-Consultant, King AbdelAziz City of Science and Technology, 2010-presnt
-Associate Editor, Frontiers in Microbiology, 2010-present
-Associate Editor, Bacteriology ISRN, 2013-present
-Graduate student advisory committee for at least 20 students in Pathology, Microbiology and Comparative Biomedical Sciences graduate programs, 2002-present
-Biology Major, Faculty Member, 2006-present
-Senator, University of Wisconsin Faculty Senate, 2004-present
-Teaching “Molecular Biology Techniques”, PBS500, 3 credit hrs from 2004-present, Average 40 students
During the past decade, I have mentored 17 undergraduate, 19 graduate students and 10 post-doctoral fellows in my laboratory at the University of Wisconsin-Madison.
- Marcus, S.A., Sidiropoulos, S.W., Steinberg, H., Talaat, A.M.* CsoR Is Essential for Maintaining Copper Homeostasis in Mycobacterium tuberculosis. PlosOne. 2016, 11: e0151816.
- Shippy, D. C., J. J. Lemke, A. Berry, K. Nelson, M. E. Hines, 2nd and A. M. Talaat*. Superior protection from live-attenuated vaccines directed against Johne's disease. Clin. Vacc. Immunol. 2017. 5: 24(1)
- Grant, I. R., A. C. G. Foddai, J. C. Tarrant, B. Kunkel, F. A. Hartmann, S. McGuirk, C. Hansen, Talaat, A.M., Collins, M. J Dairy Sci. 2017. 100(12): 9723-9735.
- Berry, A, Wu, C-W, Venturino, A.J and Talaat, A.M.* Biomarkers for Early Stages of Johne’s Disease Infection and Immunization in Goats. Front.Microbiol. 2018. 9:2284
- Alyamani, E., S. A. Marcus, S. M. Ramirez-Busby, C. Hansen, J. Rashid, A. El-Kholy, D. Spalink, Talaat, A.M*. (2019). Transmission dynamics of Mycobacterium tuberculosis in The Middle East. (In Press)
- Ali, Z.I., Saudi, A.M., Albrecht, R. and Talaat, A.M. The Inhibitory Effect of Nisin on Mycobacterium avium subspecies paratuberculosis and Its Impact on Mycobacterial Cell Wall. J Dairy Sci. 2019 (In Press).