Lauren Trepanier, DVM, PhD, DACVIM (SAIM), DACVCP

Department of Medical Sciences
Office: 4254

Lauren Trepanier, DVM, PhD, DACVIM (SAIM), DACVCP

Titles and Education

  1. Professor, Internal Medicine
  2. Assistant Dean for Clinical and Translational Research

  3. Diplomate, ACVCP
  4. Diplomate, ACVIM
  5. Ph.D., Pharmacology, Cornell University
  6. Internship and Residency in Small Animal Internal Medicine, The Animal Medical Center, NYC
  7. D.V.M. with honors, Cornell University
  8. B.S., The College of William and Mary


Dr. Trepanier works on the interaction between genetics and environmental chemicals in the risk of certain cancers in dogs and people. Her lab is currently studying bladder cancer and lymphoma in dogs.


Dr. Trepanier runs a research lab and oversees training initiatives to involve vet students and veterinarians in research that advances clinical veterinary medicine and translation to human health.

Clinical Interests

Dr. Trepanier retired from clinics in January 2021, but has always loved working up cases of liver disease and complex cases with potential drug interactions.

Graduate Training

Member, Graduate faculties of Pharmaceutical Sciences, Molecular and Environmental Toxicology, and Comparative Biosciences

Video: Turning a Clinical Question into a Testable Hypothesis

Recent Publications

  1. Smith N, Luethcke KR, Trepanier LA. Risk of bladder cancer and lymphoma in dogs is associated with pollution indices by county of residence. Vet Comp Oncol, Epub Sep 2021.
  2. Craun K, Luethcke KR, Shafer M, Stanton N, Zhang C, Schauer J, Joshua Faulkes J, Sundling KE, Kurtycz D, Malecki M, Trepanier LA. Environmental chemical exposures in the urine of dogs and people sharing the same household. J Clin Translat Sci, 5(1):e54, 2020.
  3. Craun K, Ekena J, Sacco J, Jiang T, Motsinger-Reif, Trepanier LA. Genetic and environmental risk for lymphoma in boxer dogs. J Vet Intern Med, 34:2068-2077, 2020.
  4. Luethcke KR, Ekena J, Chun R, Trepanier LA. Glutathione S-transferase theta genotypes and environmental exposures in the risk of canine transitional cell carcinoma. J Vet Intern Med,33:1414-1422, 2019. 
  5. Ekena J, Wood E, Manchester A, Chun R, Trepanier LA. GST-theta genotypes and the risk of cyclophosphamide toxicity in dogs, Vet Comp Oncol16:529-534, 2018
  6. Reinhart J, Ekena J, Cioffi A, Trepanier LA. A single nucleotide polymorphism in the canine cytochrome b5 reductase (CYB5R3) gene is associated with sulfonamide hypersensitivity and is overrepresented in Doberman Pinschers. J Vet Pharmacol Ther 41:402-408,2018.
  7. Craft A, Ekena J, Mayer B, Thamm DH, Saba C, Chun R, Trepanier LA. Characterization of a low expression haplotype in canine glutathione-S-transferase (GSTT1) and its prevalence in golden retrievers. Vet Comp Oncol, 16:E61-E67, 2018.
  8. Craft A, Ekena J, Sacco J, Luetchke, Trepanier LA. A 6 bp deletion variant in a novel canine glutathione-S-transferase gene (GSTT5) leads to loss of enzyme function. J Vet Intern Med31:183301840, 2017.
  9. Ginn J, Sacco J, Wong YY, Motsinger-Reif A, Chun R, and Trepanier LA. Positive association between a glutathione-S-transferase (GSTT1) polymorphism and lymphoma in dogs. Vet Comp Oncol 12:227-236, 2014.
  10. Blanke K, Sacco J, Millikan R, Olshan AF, Luo J, Trepanier LA. Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women. Cancer Causes and Control. 25:1513-21, 2014.