DMS Faculty Office: 4254

• Associate Professor, Internal Medicine
• B.S., The College of William and Mary, 1981
• D.V.M., Cornell University, 1986
• Internship and Residency in Small Animal Internal Medicine, The Animal Medical Center, NY, NY, 1986-1989
• Diplomate, ACVIM, 1991
• Ph.D., Cornell University, 1997
• Diplomate, ACVCP, 1998

Dr. Trepanier's research area is genetically determined differences in drug metabolism and their effect on the individual risk of drug toxicity. The major focus of her laboratory is the effect of variability in drug reduction pathways (cytochrome b5 and its reductase, and antioxidant pathways) on arylamine carcinogenesis, and on the outcome of sulfonamide hypersensitivity reactions in dogs and humans (particularly immunocompromised patients).

Clinical pharmacology and therapeutics, particularly adverse drug reactions and drug interactions; Small animal internal medicine, particularly hematology and hepatology.

Lavergne SN, Kurian JR, Bajad SU, Maki JE, Yoder AE, Guzinski MV, Graziano FM, Trepanier LA. Roles of endogenous ascorbate and glutathione in the cellular reduction and cytotoxicity of sulfamethoxazole-nitroso. Toxicology 2006 Feb 10; [Epub ahead of print]

Trepanier LA, Bajad SU, Kurian JR. Evaluation of the cytochrome b5 / cytochrome b5 reductase pathway. Current Protocols in Toxicology (invited review) 4.16.1-4.16.17, 2005.

Saulter JY, Kurian JR, Trepanier LA, Tidwell RR, Bridges AS, Boykin DW, Stephens CE, Anbazhagan M, Hall JE. Unusual dehydroxylation of antimicrobial amidoxime prodrugs by cytochrome b5 and NADH cytochrome b5 reductase. Drug Metab Disp 33:1886-1893, 2005.

Lavergne SN, Volkmann EM, Maki JE, Yoder AR, Trepanier LA. Evaluation of the clinical, immunologic, and biochemical effects of nitroso sulfamethoxazole administration to dogs: a pilot study. Toxicology 208: 63-72, 2005.

Kurian JR, Bajad S, Miller JL, Chin N, Trepanier LA. NADH cytochrome b5 reductase and cytochrome b5 catalyze the microsomal reduction of xenobiotic hydroxylamines and amidoximes in humans. J Pharmacol Exp Ther 311:1171-8, 2004.

Trepanier LA, Yoder AR, Bajad S, Beckwith MD, Bellehumeur JL, Graziano FM. Plasma ascorbate deficiency is associated with impaired reduction of sulfamethoxazole nitroso in HIV infection. J Acquir Immunodef Syndr 36:1041-1050, 2004.

Trepanier LA, Danhof R, Toll J, Watrous D. Clinical findings in 40 dogs with hypersensitivity associated with potentiated sulfonamides. J Vet Intern Med 17: 647-652, 2003.

Kurian JR, Bajad S, Miller JL, Chin N, Trepanier LA. NADH cytochrome b5 reductase and cytochrome b5 catalyze the microsomal reduction of xenobiotic hydroxylamines and amidoximes in humans. J Pharmacol Exp Ther August 9, 2004 [Epub ahead of print].

Trepanier LA. Idiosyncratic toxicity associated with potentiated sulfonamides in the dog. J Vet Pharmacol Ther 27: 129-138, 2004.

Salavaggione OE, Yang C, Kidd LB, Thomae B, Pankrantz SV. Trepanier LA, Weinshilboum RM. Cat red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics. J Pharmacol Exp Ther 308(2):617-26, 2004.

Salavaggione OE. Kidd LB, Prondzinski JL, Szumlanski CL, Pankrantz VS, Wang L. Trepanier LA, Weihnshilboum RM. Canine red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics. Pharmacogenetics 12: 713-724, 2002.