Education

• PhD 1983 University of Calgary, Medical Biochemistry
• MS 1980 University of Wisconsin-LaCrosse, Biology
• BSc 1977 University of Wisconsin-Stevens Point, Biology

Research

Dr. Aiken is ON LEAVE

Currently at:
University of Alberta
Edmonton, Canada

Transmissible Spongiform Encephalopathies (Prion Disease)

• Genetic Susceptibility
• Environmental Aspects
• Diagnostics

 Role of Mitochondrial in Aging Processes

• Skeletal muscle
• Kidney

Recent Publications

CLICK HERE for complete publication list

McKiernan, S.H., V.C. Tuen, K. Baldwin, J. Wanagat, A. Djamali and J.M. Aiken. Adult-onset Calorie Restriction Delays the Accumulation of Mitochondrial Enzyme Abnormalities in Aging Rat Kidney Tubular Epithelial Cells. Journal of Applied Physiology-Renal, in press.

Ma, X., C. Benson, D. McKenzie, J.M. Aiken, and J. A. Pedersen. Adsorption of Pathogenic Prion Protein to Quartz Sand. Environmental Science and Technology, In press.

Bua, E., D. McKenzie and J. Aiken. Mitochondrial DNA Mutations. In Encyclopedia of Aging. In press

McKenzie, D. and J. Aiken. Mitochondria and Aging. In Encyclopedia of Gerontology, in press.

Herbst, A., J. Pak, D. McKenzie, E. Bua, M. Bassiouni and J.M. Aiken. Accumulation of Mitochondrial DNA Deletion Mutations in Aged Muscle Fibers: Evidence for a Causal Role in Muscle Fiber Loss, Journals of Gerontology Series A Biological Sciences and Medical Sciences, in press.

Schramm. P.T., C.J. Johnson, N.E. Mathews, D. McKenzie, J.M. Aiken and J.A. Pedersen. 2006. Potential Role of Soil in the Transmission of Prion Diseases. Medical Mineralogy and Geochemistry in the Review in Mineralogy and Geochemistry Series (RiMS), 64: 133-152.

Bua, E., J. Johnson, A. Herbst, B. Delong, D. McKenzie, S. Salamat and J.M. Aiken. 2006. Mitochondrial DNA deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers. American Journal of Human Genetics. 79:469-480. [Abstract]

Johnson, C.J., J. Johnson, D. Keane, J. Vanderloo, M. Clayton, D. McKenzie, P. Bochsler and J.M. Aiken. 2006. Prion protein polymorphisms in white-tailed deer populations influence susceptibility to chronic wasting disease. Journal of General Virology, 87:2109-2114. [Abstract]

Johnson, C.J., K.E. Phillips, P.T. Schramm, D. McKenzie, J.M. Aiken and J.A. Pedersen. 2006. Prions adhere to soil minerals and remain infectious. PLoS Pathogens 2:e32. [Abstract]

Hacker, T., S. McKiernan, P.S. Douglas, J. Wanagat and J.M. Aiken. 2006. Age-related changes in cardiac structure, function, and morphology in Fisher 344 X Brown Norway hybrid rats. American Journal of Physiology-Heart and Circulatory Physiology 290: H304 - H311 [Abstract]