Keil Stietz Lab
University of Wisconsin – School of Veterinary Medicine

Publications

Link to My Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/kimberly.keil.1/bibliography/public/

 

Representative Publications

  1. Lavery T, Spiegelhoff A, Wang K, Kennedy CL, Ridlon M Keil Stietz KP. (2023). Polychlorinated biphenyl (PCB) exposure in adult female mice can influence bladder contractility. Am J Clin Exp Urol. 11(5):367-384. PMCID: PMC10628623.
  2. Spiegelhoff A, Wang K, Ridlon M, Lavery T, Kennedy CL, George S, Keil Stietz KP. (2023). Polychlorinated biphenyls (PCBs) impact prostatic collagen density and bladder volume in young adult mice exposed during in utero and lactational development. Toxics. 11(7): 609. PMCID: PMC10384510.
  3. Zhang CY, Li X, Keil Stietz K, Sethi S, Yang W, Marek R, Ding X, Lein P, Hornbuckle K, Lehmler, H-Joachim. (2023). Rebuttal to Correspondence on Machine Learning-Assisted Identification and Quantification of Hydroxylated Metabolites of Polychlorinated Biphenyls in Animal Sample. Environ Sci Technol. Apr 18;57(15):6251-6252. PMID: 37017328.
  4. Zhang CY, Li X, Keil Stietz K, Sethi S, Yang W, Marek R, Ding X, Lein P, Hornbuckle K, Lehmler, H-Joachim. (2022). Machine learning-assisted identification and quantification of hydroxylated metabolites of polychlorinated biphenyls in animal samples. Environ Sci Technol. Sep 20;56(18):13169-13178. PMCID: PMC9573770.
  5. Kennedy CL, Spiegelhoff A, Lavery T, Wang K, Manuel RJ, Wang Z, Wildermuth H, Keil Stietz K. (2022). Developmental polychlorinated biphenyl (PCB) exposure alters voiding physiology in young adult male and female mice. Am J Clin Exp Urol. 10(2):82-97. PMCID: PMC9077147
  6. Keil Stietz KP., Sethi S., Klocke CR., de Ruyter T., Wilson MD., Pessah I., Lein PJ. (2021). Sex and Genotype Modulate the Dendritic Effects of Developmental Exposure to a Human-Relevant Polychlorinated Biphenyls Mixture in the Juvenile Mouse. Frontiers in Neuroscience, 15:1610. 10.3389/fnins.2021.766802.
  7. Sethi S., Keil Stietz KP*., Valenzuela AE., Klocke CR., Silverman JL., Puschner B., Pessah IN., Lein PJ. (2021) Developmental Exposure to a Human-Relevant PCB Mixture Causes Behavioral Phenotypes that Vary by Sex and Genotype in Juvenile Mice Expressing Human Mutations that Modulate Neuronal Calcium. Frontiers in Neuroscience, 15:1689. 10.3389/fnins.2021.766826. *Co-first authorship.
  8. Kennedy, C.L., Spiegelhoff, A., Wang, K., Lavery, T., Nunez, A., Manuel, R., Hillers-Ziemer, L., Arendt, L.M., Stietz, K.P.K. (2021). The bladder is a novel target of developmental polychlorinated biphenyl exposure linked to increased inflammatory cells in the bladder of young mice. Toxics, 9(9):214. https://doi.org/10.3390/toxics9090214. PMCID- PMC8473463.
  9. Turco AE, Oakes SR, Keil Stietz KP, Dunham CL, Joseph DB, Chathurvedula TS, Girardi NM, Schneider AJ, Gawdzik J, Sheftel CM, Wang P, Wang Z, Bjorling DE, Ricke WA, Tang W, Hernandez LL, Keast JR, Bonev AD, Grimes MD, Strand DW, Tykocki NR, Tanguay RL, Peterson RE, Vezina CM. (2021). A neuroanatomical mechanism linking perinatal TCDD exposure to lower urinary tract dysfunction in adulthood. Disease Models and Mechanisms, 14(7). https://doi.org/10.1242/dmm.049068. PMCID- PMC8326766.
  10. Abler LL, O’Driscoll CA, Colopy SA, Keil Stietz KP, Wang P, Wang Z, Hartmann F, Crader-Smith SM, Oellete JN, Mehta V, Oakes S, Grimes MD, Mitchell GS, Baan M, Gallagher SJ, Davis D, Kimple ME, Bjorling DE, Watters JJ, Vezina CM. (2021). The influence of intermittent hypoxia, obesity and diabetes on male genitourinary anatomy and voiding physiology. American Journal of Physiology Renal. In Press. https://doi.org/10.1152/ajprenal.00112.2021.
  11. Keil Stietz KP*, Kennedy CL, Sethi S, Valenzuela A, Nunez A, Wang K, Wang, Z, Wang P, Speigelhoff A, Puschner B, Bjorling DE, Lein PJ. (2021). In utero and lactational PCB exposure drives anatomic changes in the juvenile mouse bladder. Current Research in Toxicology. 2:1-18. PMCID-PMC8317607. *Corresponding authorship.
  12. Panesar HK, Kennedy CL, Keil Stietz KP*, Lein PJ*. (2020). Polychlorinated Biphenyls (PCBs): Risk Factors for Autism Spectrum Disorder?. Toxics. 17;8(3):E70. PMCID-in process. *Co-corresponding authorship.
  13. Matelski L, Keil Stietz KP, Sethi S, Taylor SL, Van de Water J, Lein PJ. (2020). The Influence of Sex, Genotype, and Dose on Serum and Hippocampal Cytokine Levels in Juvenile Mice Developmentally Exposed to a Human-Relevant Mixture of Polychlorinated Biphenyls. Current Research in Toxicology. 1:85-103. doi: https://doi.org/10.1016/j.crtox.2020.09.001.
  14. Schmuck MR, Keil KP, Sethi S, Morgan RK, Lein PJ. (2020). Automated high content image analysis of dendritic arborization in primary mouse hippocampal and rat cortical neurons in culture. J. Neurosci Methods. 341:108793. PMCID – PMC7357201.
  15. Wang Z, Guzman EC, Nimunkar A, Keil KP, Vezina CM, Ricke WA, Macoska J, Bjorling DE (2019). Void Sorcerer: an Open Source, Open Access Framework for Mouse Uroflowmetry. Am J Clin Exp Urol. 7(3):170-177. PMCID – PMC6627548.
  16. Rude K, Pusceddu MM, Keogh CE, Sladek JA, Rabasa G, Miller EM, Sethi S, Keil KP, Pessah IN, Lein PJ, Gareau MG. (2019). Developmental exposure to polychlorinated biphenyls (PCBs) in the maternal diet causes host-microbe defects in weanling offspring mice. Environmental Pollution. 253:708-721. PMCID – PMC6719698.
  17. Keil KP*, Miller GW*, Chen H, Sethi S, Schmuck MR, Dhakal K, Kim JW, Lein PJ. (2018). PCB 95 promotes dendritic growth in primary rat hippocampal neurons via mTOR-dependent mechanisms. Arch Toxicol. 92(10):3163-3173. *Co-first authorship. PMCID – PMC6162988.
  18. Sethi S, Keil KP, Lein PJ. (2018). 3,3ʹ-Dichlorobiphenyl (PCB 11) Promotes Dendritic Arborization in Primary Rat Cortical Neurons via CREB-Dependent Mechanisms. Arch Toxicol. 92(11):3337-3345. PMCID – PMC6196112.
  19. Keil KP, Sethi S, Wilson MD, Silverman JS, Pessah IN, Lein PJ. (2018). Genetic mutations in Ca2+ signaling alter dendrite morphology and social approach in juvenile mice. Genes Brain Behav. e12526. PMCID – PMC6540090.
  20. Keil KP, Sethi S, Lein PJ. (2018). Sex differences in dendrite morphology in response to 2,2′,3,5′,6-pentachlorobiphenyl (PCB 95) in cultured primary mouse neurons. Tox Sci. doi: 10.1093/toxsci/kfy277. In Press. PMCID – PMC6390665.
  21. Granillo, L., Sethi, S., Keil, KP., Lin, Y., Ozonoff, S., Iosif, A.-M., Puschner, B., Schmidt, R. J. (2018). Polychlorinated biphenyls influence on autism spectrum disorder risk in the MARBLES cohort. Environmental Research, 171, 177-184. PMCID – PMC6382542.
  22. Wilson MD, Sethi S, Lein PJ, Keil KP. (2017). Valid statistical approaches for analyzing sholl data: mixed effects versus simple linear models. J. Neurosci Methods. 279:33-43. PMCID – PMC5346342.
  23. Sethi S, Keil KP, Chen H, Hayakawa K, Lin Y, Li X, Lehmler HJ, Puschner B, Lein PJ. (2017). Detection of 3,3’-dichlorobiphenyl in human maternal plasma and its effects on axonal and dendritic growth in primary rat neurons. Tox Sci. 158(2):401-411. PMCID – PMC5837364.
  24. Keil KP, Sethi S, Wilson MD, Chen H, Lein PJ (2017). Dendritic morphology varies between sexes in juvenile mice and in vitro models of neurodevelopment. Sci Rep. 7(1): 8486. PMCID – PMC5559594.
  25. Sethi S, Keil KP, Lein PJ. (2017). Species and sex differences in the morphogenic response of primary rodent neurons to 3,3ʹ-Dichlorobiphenyl (PCB 11). Toxics. 6 (1). PMCID – PMC5874777.
  26. Ricke WA, Lee C, Clapper T, Schneider AJ, Moore RW, Keil KP, Abler LL, Wynder JL, Alvarado AL, Beaubrun I, Vo J, Bauman TM, Ricke EA, Peterson RE, Vezina CM (2016). In utero and lactational TCDD exposure increases susceptibility to lower urinary tract dysfunction in adulthood. Tox Sci. 50(2):429-40. PMCID – PMC26865671.
  27. Keil KP, Lein PJ. (2016). DNA methylation: A mechanism linking environmental chemical exposures to risk of autism spectrum disorders? Environ Epigenet. 2 (1): dvv012. PMCID – PMC4856164.
  28. Bal-Price A, Lein PJ, Keil KP, Sethi S, Shafer T, Barenys M, Fritesche E, Sachana M, Meek B. (2016) Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity. Neurotoxicology. 10.1016/j.neuro.2016.05.010. PMCID – PMC5114159.
  29. Keil KP, Abler LL, Altmann HM, Wang Z, Wang P, Ricke WA, Bjorling DE, Vezina CM. (2015). Impact of a folic acid enriched diet on lower urinary tract function in mice treated with testosterone and estradiol. Am J Physiol Renal Physiol. 308(12): 1431-43. PMCID – PMC4469891.
  30. Bjorling DE, Wang Z, Vezina CM, Ricke WA, Keil KP, Yu W, Guo L, Zeidel ML, Hill WG. (2015). Evaluation of voiding assays in mice: impact of genetic strains, gender and testing site. Amer J Physiol Renal Physiol. 308(12): 1369-78. PMCID – PMC4469884.
  31. Keil KP, Vezina CM. (2015). DNA methylation as a dynamic regulator of development and disease processes: spotlight on the prostate. Epigenomics. 7(3): 413-425. PMCID – PMC4500939.
  32. Keil KP, Abler LL, Altmann HM, Bushman W, Marker PC, Li L, Ricke WA, Bjorling DE, Vezina CM. (2014). Influence of animal husbandry practices on void spot assay outcomes in C57BL/6J male mice. Neurourol Urodynam. doi: 10.1002/nau.22692. PMCID – PMC4428995.
  33. Keil KP, Abler LL, Laporta J, Altmann HM, Yang B, Jarrard DF, Hernandez LL, Vezina CM. (2014). Androgen receptor DNA methylation regulates the timing and androgen sensitivity of mouse prostate ductal development. Dev Biol. 396: 79-87. PMCID – PMC4261055.