“The research program in my lab focuses on cell signaling, in particular Ras signaling, in hematopoiesis and leukemogenesis. We generated and characterized multiple genetically engineered mouse models for oncogenic Ras-driven blood cancers, including juvenile monocytic leukemia, chronic myelomonocytic leukemia and its transformation to acute myeloid leukemia, multiple myeloma, and early T cell precursor acute lymphoblastic leukemia. We use these models along with cell lines and patient samples to:
1. Study how genetic mutations alter hematopoietic stem and progenitor cell functions to promote blood cancers
2. Investigate disease mechanisms using multi-Omics approach
3. Develop mechanism-based novel combination targeted therapies and immunotherapies
4. Validate therapeutic strategies in preclinical models in vitro and in vivo”