Jyoti Watters

Comparative Biosciences

jjwatters@wisc.edu

Research Program

The role of microglial cells (a macrophage cell type that resides in the brain) in the progression of neurologic disease and inflammatory disorders in the central nervous system. The excessive activation of these cells is thought to contribute to neurotoxicity and inflammatory damage in the brain resulting from a large number of diseases. Intracellular signal transduction mechanisms initiated in microglial cells following their activation by various stimuli, including neurotransmitters, hormones and toxins. Understanding these intracellular processes and their involvement in microglial cell activation will allow for the identification of novel therapeutic targets that can be used to minimize brain damage following a neurologic insult.

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