Jenny Gumperz

Medical Microbiology & Immunology

Research Program

Although most T cells recognize peptide antigens that derive from non-self proteins and are presented at the cell surface by MHC molecules, NKT cells are activated by lipid and glycolipid antigens presented by CD1d molecules.  NKT cells can become activated by self lipids, which means that they can perform functions even when there is no infectious challenge.  The central focus of my lab is to understand how this autoreactivity contributes to immune regulation.

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