Titles and Education

1. Titles and previous positions
   1. Associate Professor, University of Wisconsin-Madison, Department of Pathobiological Sciences, School of Veterinary Medicine (2023-present)
   2. Research Director - PI (DR2 INSERM), Institute Molecular Microbiology and Structural Biochemistry, CNRS-Univ. Lyon, France (2012-2023)
   3. Junior Research Scientist (CR INSERM), Centre d'Immunologie Marseille-Luminy, France (2005-2012), team of Jean-Pierre Gorvel
   4. Postdoctoral fellow, Centre d'Immunologie Marseille-Luminy, France (2003-2005), team of Jean-Pierre Gorvel
     Education
   1. Ph.D. in Cellular Microbiology — Imperial College London, United Kingdom (2003)
   2. M.Sc. in Infectiious Diseases — Hammersmith Hospital, Imperial College, United Kingdom (1999)
   3. B.Sc. in Microbiology — School of Biotechnology (UC-ESB), Porto, Portugal (1998)

Research

Our group is interested in studying bacterial-host interactions, particularly the role of bacterial proteins that promote virulence. These proteins may modify host cell signaling to aid replication, allow the pathogen to subvert the immune response, or enable colonization of the host and abiotic surfaces in a hospital setting. We apply integrated molecular and cellular approaches to characterize these bacterial molecules and how they modulate cellular functions to contribute to disease in both humans and animals.

Recent Publications

1. Moreno E et al. (2023) If You're Not Confused, You're Not Paying Attention: Ochrobactrum Is Not Brucella. J Clin Microbiol. 2023 Aug 23;61(8):e0043823. doi: 10.1128/jcm.00438-23
2. Louche A, Blanco A, Lacerda TLS, Lionnet C, Bergé C, Rolando M, Lembo F, Borg4 JP, Buchrieser C, Nagahama M, Gorvel JP, Gueguen-Chaignon V, Terradot L, Salcedo SP (2023) The unique Brucella effectors NyxA and NyxB target SENP3 to modulate the subcellular localisation of nucleolar proteins. Nature Communications 14(1):102. doi: 10.1038/s41467-022-35763-
3. Leukert L, Tietgen M, Krause FF, Schultze TG, Fuhrmann DC, Debruyne C, Salcedo SP, Visekruna A, Wittig L, Göttig S. (2023) Infection of Endothelial Cells with Acinetobacter baumannii Reveals Remodelling of Mitochondrial Protein Complexes. Microbiology Spectrum.11(3):e0517422. doi: 10.1128/spectrum.05174-22.
4. Rubio T, Gagné S, Debruyne C, Dias C, Cluzel C, Mongellaz D, Rousselle P, Göttig S, Seifert H, Higgins PG, Salcedo SP (2021). Incidence of an intracellular multiplication niche amongst Acinetobacter baumannii clinical isolates. MSystems 7(1):e0048821. doi: 10.1128/msystems.00488-21
5. Luizet JB, Raymond J, Lacerda TLS, Barbieux E, Kambarev S, Bonici M, Lembo F, Willemart K, Borg JP, Celli J, Gérard FCA, Muraille E, Gorvel JP and Salcedo SP (2021) The Brucella effector BspL targets the ER-associated degradation (ERAD) pathway and delays bacterial egress from infected cells. Proc Natl Acad Sci USA 118(32):e2105324118. doi: 10.1073/pnas.2105324118
6. Roussin M and Salcedo SP (2021) NAD+-targeting by bacteria: an emerging weapon in pathogenesis. FEMS Microbiol Rev. fuab037. doi: 10.1093/femsre/fuab037 Coronas-Serna JM, Louche A, Rodríguez-Escudero M, Roussin M, Imbert PRC, Rodríguez-Escudero I, Molina M, Gorvel JP, Cid VJ*, Salcedo SP* (2020)
7. The TIR-domain containing effectors BtpA and BtpB from Brucella abortus block energy metabolism. PLoS Pathogens16(4):e1007979. doi: 10.1371/journal.ppat.1007979
8. Complete list of publications: ORCID or Google Scholar