Titles and Education

1. Clinical Assistant Professor, Clinical Pathology (2019 to present)
2. Clinical Pathologist I, Covance Laboratories, Inc., Madison, WI (2019)
    
3. Diplomate of the American College of Veterinary Pathologists, Clinical Pathology (2018)
    
4. Clinical Instructor, Clinical Pathology, The Ohio State University, Columbus, OH (2018)
5. PhD, Comparative and Veterinary Medicine, The Ohio State University, Columbus, OH (2018)
6. Dual Clinical Pathology Resident and PhD Student, The Ohio State University, Columbus, OH (2013-2018)
7. DVM, University of Wisconsin-Madison (2013)
8. BS with Comprehensive Honors, Biology and Spanish, University of Wisconsin-Madison (2009)

Research

Flow cytometric evaluation of hematologic malignancies; comparative clinical pathology; development and characterization of mouse models of hematopoietic neoplasia; animal models of allogeneic bone marrow transplantation; pathogenesis of veterinary immune-mediated diseases

Responsibilities

Diagnostic clinical pathology service
Teaching: Second year Clinical Pathology; guest lecturer in first year Histology - clinical correlates for leukocytes and bone marrow; guest lecturer in fourth year Clinical Pathology Elective (Spring and Fall);

Clinical Interests

Diagnostic flow cytometry; comparative hematopathology; hematologic malignancies; cytopathology; laboratory quality assurance; methodology of hematology and serum biochemistry analyzers

Graduate Training

Current and former Clinical Pathology residents:

Angela Borchers, DVM, DACVIM (LAIM), DACVECC (current resident)
Omer Lerman, DVM, MSc (current resident)
Diya Sharma, DVM, MPVM 

Recent Publications

1. McAloney CA, Zitzer NC, Taikowski KL, Breen M, Kennedy KA, Wellman ML, Hokamp JA. Pathology in Practice: Neutrophilic exudate with evidence of bacterial infection and malignant epithelial neoplasia in peritoneal effusion in a dog. JAVMA. In press.
2. Snyder KJ, Zitzer NC, Gao Y, Choe HK, Sell NE, Neidemire-Colley L, Ignaci A, Kale C, Devine RD, Abad MG, Pietrzak M, Wang M, Lin H, Zhang YW, Behbehani GK, Jackman JE, Garzon R, Vaddi K, Baiocchi RA, Ranganathan P. PRMT5 regulates T cell interferon response and is a target for acute graft-versus-host disease. JCI Insight. 2020;5(8):e131099. Published 2020 Apr 23. doi:10.1172/jci.insight.131099
3. Long ME, Mustonen AM, Zitzer NC, Byron JK, Wellman ML, Cianciolo RE, Hokamp JA. Persistent nonregenerative anemia in a 4-year-old cat. Vet Clin Pathol. 2020;49(1):11-16. doi:10.1111/vcp.12837
4. Bill M, Pathmanathan A, Karunasiri M, hen C, Burke M, Ranganathan P, Papaioannou D, Zitzer N, Snyder K, LaRocco A, Walker A, Brannan Z, Nalin A, Freud A, Dikov M, Zhang X, Bloomfield C, Garzon R, Dorrance A. EGFL7 Antagonizes NOTCH Signaling and Represents a Novel Therapeutic Target in Acute Myeloid Leukemia. Clin Cancer Res. 2020;26(3):669-678. doi:10.1158/1078-0432.CCR-19-2479
5. Papaioannou D, Petri A, Dovey OM, Terreri S, Wang E, Collins FA, Woodward LA, Walker AE, Nicolet D, Pepe F, Kumchala P, Bill M, Walker CJ, Karunasiri M, Mrózek K, Gardner ML, Camilotto V, Zitzer N, Cooper JL, Cai X, Rong-Mullins X, Kohlschmidt J, Archer KJ, Freitas MA, Zheng Y, Lee RJ, Aifantis I, Vassiliou G, Singh G, Kauppinen S, Bloomfield CD, Dorrance AM, Garzon R. The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia [published correction appears in Nat Commun. 2020 Jan 7;11(1):204] [published correction appears in Nat Commun. 2020 Jul 29;11(1):3878]. Nat Commun. 2019;10(1):5351. Published 2019 Nov 25. doi:10.1038/s41467-019-13259-2
6. Zitzer NC, Garzon R, Ranganathan P. Toll-Like Receptor Stimulation by MicroRNAs in Acute Graft-vs.-Host Disease. Front Immunol. 2018;9:2561. Published 2018 Nov 5. doi:10.3389/fimmu.2018.02561
7. Zitzer NC, Snyder K, Meng X, Taylor PA, Efebera YA, Devine SM, Blazar BR, Garzon R, Ranganathan P. MicroRNA-155 Modulates Acute Graft-versus-Host Disease by Impacting T Cell Expansion, Migration, and Effector Function. J Immunol. 2018;200(12):4170-4179. doi:10.4049/jimmunol.1701465
8. Papaioannou D, Shen C, Nicolet D, McNeil B, Bill M, Karunasiri M, Burke MH, Ozer HG, Yilmaz SA, Zitzer N, Behbehani GK, Oakes CC, Steiner DJ, Marcucci G, Powell BL, Kolitz JE, Carter TH, Wang ES, Mrózek K, Croce CM, Caligiuri MA, Bloomfield CD, Garzon R, Dorrance AM. Prognostic and biological significance of the proangiogenic factor EGFL7 in acute myeloid leukemia. Proc Natl Acad Sci U S A. 2017;114(23):E4641-E4647. doi:10.1073/pnas.1703142114
9. Ranganathan P, Ngankeu A, Zitzer NC, Leoncini P, Yu X, Casadei L, Challagundla K, Reichenbach DK, Garman S, Ruppert AS, Volinia S, Hofstetter J, Efebera YA, Devine SM, Blazar BR, Fabbri M, Garzon R. Serum miR-29a Is Upregulated in Acute Graft-versus-Host Disease and Activates Dendritic Cells through TLR Binding. J Immunol. 2017;198(6):2500-2512. doi:10.4049/jimmunol.1601778
10. Zitzer NC, Marsh AE, Burkhard MJ, Radin MJ, Wellman ML, Jugan M, Parker V. Parasitemia due to Sarcocystis neurona-like infection in a clinically ill domestic cat. Vet Clin Pathol. 2017;46(3):526-532. doi:10.1111/vcp.12541
11. Schwartz Z, Zitzer NC, Racette MA, Manley PA, Schaefer SL, Markel MD, Hao Z, Holzman G, Muir P. Are bacterial load and synovitis related in dogs with inflammatory stifle arthritis?. Vet Microbiol. 2011;148(2-4):308-316. doi:10.1016/j.vetmic.2010.09.011
12. Muir P, Fox R, Wu Q, Baker TA, Zitzer NC, Hudson AP, Manley PA, Schaefer SL, Hao Z. Seasonal variation in detection of bacterial DNA in arthritic stifle joints of dogs with cranial cruciate ligament rupture using PCR amplification of the 16S rRNA gene. Vet Microbiol. 2010;141(1-2):127-133. doi:10.1016/j.vetmic.2009.08.015