Jonathan McAnulty, DVM, PhD, Professor and Chair, Department of Surgical Sciences

jonathan.mcanulty@wisc.edu

Department of Surgical Sciences
Office: 2023

Jonathan McAnulty, DVM, PhD, Professor and Chair, Department of Surgical Sciences

Titles and Education

  1. Current - Professor of Surgery, University of Wisconsin
  2. Chair, Department of Surgical Sciences
  3. DVM 1981, University of Georgia
  4. Internship 1982, Purdue University
  5. Surgical Residency 1985, University of Pennsylvania
  6. MS 1989, University of Wisconsin
  7. PhD 1994, University of Wisconsin

Research

Research in Dr. McAnulty's laboratory is currently focused on studies on engineering the molecular basis of wound surfaces for augmentation of healing and suppression or dissolution of bacterial biofilms from the wound surface. This work is focused on methods for attachment of various active molecules to the wound surface to alter the wound surface characteristics and properties at the nanoscale level. These studies involve a multilaboratory and multiinstitutional collaborative group and are funded by the National Institutes of Health. Other research involves studies on mechanisms of cellular injury during hypothermia and ischemia. These studies relate to both low temperature cardiopulmonary bypass methods and to organ preservation for transplantation. The thrust of this work is to reduce injury to organs stored for transplantation in order to reduce the incidence of delayed function and chronic allograft nephropathy as well as to increase the donor organ supply for human transplantation and to advance the field of veterinary transplantation.

Responsibilities

Administrative
     Chair, Dept. of Surgical Sciences
Teaching
     Small animal general surgery: lectures, labs
     Clinical instruction in soft tissue surgery
Research
     Nanoscale engineering of wound surfaces to promote healing
     Clinically related projects
     Organ preservation for transplantation
     Research mentoring of residents and graduate students

Clinical Interests

Basic biology of wound healing and development of novel methods for stimulating non-healing wounds, plastic  and reconstructive surgery, treatment of chylothorax and organ transplantation.

Graduate Training

Mentoring of residents in our small animal clinical surgical training program
Mentoring of graduate students in laboratory research

Recent Publications

    1. McAnulty JF, Budgeon C. Catheter Occlusion of the Dorsal Sagittal Sinus-Confluens Sinuum to Enable Resection of Lateral Occipital Multilobular Osteochondrosarcoma in Two Dogs (2015-2017). JAVMA, 254:843-851, 2019.
    1. Brandenburg KS, Calderon DF, Kierski PR, Czuprynski CJ, McAnulty JF. Novel murine model for delayed wound healing using a biological wound dressing with Pseudomonas aeruginosa biofilms. Microb Pathog. 122:30-38. 2018  doi: 10.1016/j.micpath.2018.05.043. Epub 2018 May 26. PMID: 29842898
    1. Polans AS, McAnulty JF,  Phelps PO,  Darjatmoko SR, Albert DM. Pilot Study of a “Large-Eye,” Surgically Induced Dry Eye Rabbit Model by Selective Removal of the Harderian, Lacrimal, and Meibomian Glands. Ocular Oncol and Pathol. 1:52-56. doi: 10.1159/000475994. Epub 2017 PMID: 29344500
  1. Budgeon C, Hardie R, McAnulty JF*. Use of a Carrel Patch Technique for Feline Renal Transplantation. Vet Surg 46:1139-1144, 2017.
  2.  Csomos RA, Hardie RJ, Schmiedt CW, Delaney FA, McAnulty JF*. The Impact of Cold Storage on Immediate Graft Function in Experimental Feline Renal Transplantation. Am J Vet Res, 78:330-339, 2017. doi: 10.2460/ajvr.78.3.330

  3. Chattopadhyayi S., Guthrie K.M., Teixeira L., Murphy C.J., Dubielzig R.R., McAnulty J.F*., Raines R.T.* Anchoring a cytoactive factor in a wound bed promotes healing. J Tissue Eng Regen Med, 10:1012-1020, 2016. DOI: 10.23: 251-611002/term.1886; PMID 24677775

  4. Herron M, Schurr MJ, Murphy CJ, McAnulty JF, Czuprynski CJ, Abbott NL*. Interfacial stacks of polymeric nanofilms on soft biological surfaces that release multiple agents. ACS Appl Mater Interfaces. 2016 Aug 31 (Epub ahead of print). PMID: 27579573

  5. Herron M, Schurr MJ, Murphy CJ, McAnulty JF, Czuprynski CJ, Abbott NL. Gallium-Loaded Dissolvable Microfilm Constructs that Provide Sustained Release of Ga3+ for Management of Biofilms. Adv Healthc Mater. 4:2849-2859, 2015. doi: 10.1002/adhm.201500599. PMID: 26599466

  6. Park SA, Covert J, Teixeira L, Motta MJ, DeRemer SL, Abbott NL, Dubielzig R, Schurr M, Isseroff RR, McAnulty JF*, Murphy CJ*. Importance of defining experimental conditions in a mouse excisional wound model. Wound Repair Regen. 23: 251-61, 2015. doi: 10.1111/wrr.12272.

  7. Brandenburg K, Calderon DF, Kierski PR, Brown AL, Shah NM, Abbott N., Schurr M, M, Murphy CJ, McAnulty J.F*, Czuprynski CJ*. Inhibition of Pseudomonas aeruginosa biofilm formation on wound dressings. Wound Repair Regen. 2015 23(6):842-54. doi: 10.1111/wrr.12365

  8. Tjostheim SS, Kellihan H, Csomos RA, McAnulty JF, Steinberg H. Vascular hamartoma in the right ventricle of a dog. J Vet Cardiol. 17:321-8. 2015. doi: 10.1016/j.jvc.2015.07.004.

  9. Danielson K.C., Hardie R.J., McAnulty J.F.. Outcome of donor cats after unilateral nephrectomy as part of a clinical kidney transplant program. Vet Surg 44:914-919, 2015. doi: 10.1111/vsu 12362

  10. Park S.A., Raghunathan VK, Shah NM, Teixeira L, Motta MJ, Covert J, Dubielzig R, Schurr M, Isseroff RR, Abbott NL, McAnulty J.F., Murphy CJ*. PDGF-BB does not accelerate healing in diabetic mice with splinted skin wounds. PLoS One. 9(8):e104447, 2014. doi: 10.1371/journal.pone.0104447. eCollection. PMID: 25121729

  11. Park S.A., Teixeira L.B., Raghunathan V.K., Covert J., Dubielzig R.R., Isseroff R., Schurr M., Abbott N.L., McAnulty J.F., Murphy C.J.*. Full thickness splinted skin wound healing models in db/db and heterozygous mice: implications for wound healing impairment. Wound Repair and Regeneration, 22:368-80, 2014. PMID: 24844336.

  12. Jain R., Calderon D., Kierski P., Schurr M., Czuprynski C.J., Murphy C.J., McAnulty J.F.*, Abbott N.L.* Raman spectroscopy enables non-invasive biochemical characterization and identification of the stage of healing of a wound. Analytical Chemistry, 86:3764-72, 2014. PMID 24559115

  13. Brandenburg K., Rodriguez K., McAnulty J.F., Murphy C.J., Abbott N., Schurr M., Czuprynski C. Tryptophan inhibits biofilm formation by Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 57(4):1921-1925, 2013 PMCID:PMC3623306 

  14. Guthrie, K.M., Agarwal, A., Teixeira, L.B.C., Dubielzig, R.R., Abbott, N.L., Murphy, C.J., Singh, H., Schurr, M.J., McAnulty, J.F*. Integration of silver nanoparticle-impregnated polyelectrolyte multilayers into murine splinted cutaneous wound beds. Journal of Burn Care and Research, 34:e359-367, 2013 (epub ahead of print). PMID 23511285; doi: 10.1097/BCR.0b013e31827e7ef9

  15. Jain, R., Agarwal, A., Kierski, P.R., Schurr, M.J., Murphy, C.J.*, McAnulty, J.F.*, Abbott, N.L.* The use of native chemical functional groups presented by wound beds enable covalent attachment of microbeads. Biomaterials, 34:340-352, 2013. PMID: 23088838; PMCID:PMC3651840

  16. Guthrie K.M., Agarwal A., Tackes D.S., Johnson K.W., Abbott N.L., Murphy C.J., Czuprynski C.J., Kierski P.R., Schurr M.J., McAnulty J.F.* Antibacterial efficacy of silver-impregnated polyelectrolyte multilayers immobilized on a biological dressing in a murine wound infection model. Annals of Surgery, 256: 371-377, 2012. PMCID: PMC3433034

  17. Agarwal A, Nelson T.B., Kierski P.R., Schurr M.J., Murphy C.J., Czuprynski C.J.*, McAnulty J.F*., Abbott N.L*. Polymeric  multilayers that localize the release of chlorhexidine from biologic wound dressings. Biomaterials  33:6783-92, 2012. PMCID: PMC3404134

  18. Chattopadhyay S., Murphy C.J., McAnulty J.F.*, Raines R.T.* Peptides that anneal to natural collagen in vitro and ex vivo. Organic and Biomolecular Chemistry 10: 5892-7, 2012. PMCID:PMC3395758

  19. McAnulty J.F.* Prospective Comparison of Cisterna Chyli Ablation to Pericardectomy for Treatment of Spontaneously Occurring Idiopathic Chylothorax in the Dog. Vet Surg, 40: 926–934, 2011. PMID: 22091690

  20. Staiger B.A., Stanley B.J*. and McAnulty J.F*. Single Paracostal Approach to Thoracic Duct and Cisterna Chyli: Experimental Study and Case Series. Vet Surg 40: 786-794, 2011. PMID: 22380664

  21. Agarwal A, Guthrie K.M., Czuprynski C.J., Schurr M.J., McAnulty J.F., Murphy C.J.*, Abbott N.L.*. Polymeric multilayers that contain silver nanoparticles and can be stamped onto biological tissues to provide antibacterial activity.  Advanced Functional Materials, 21(10): 1863-1873, 2011. adfm 201002662