Titles and Education

1. Professor, Internal Medicine

2. Assistant Dean for Clinical and Translational Research

3. B.S., The College of William and Mary
4. D.V.M. with honors, Cornell University
5. Internship and Residency in Small Animal Internal Medicine, The Animal Medical Center, NYC
6. Ph.D., Pharmacology, Cornell University
7. Diplomate, ACVIM
8. Diplomate, ACVCP

Research

Dr. Trepanier's research focuses on indiviudal or breed differences in xenobiotic detoxification, and their effects on the risk of drug toxicity or carcinogenesis. The laboratory's current area of research is the interaction between genetic variants in gluthathione-S-transferases, household environmental exposures, and cancer risk in dogs. She has recently studied mechanisms of idiosyncratic drug toxicity, and has ongoing studies of biomarkers of oxidative stress in dogs and cats.

Responsibilities

Assistant Dean for Clinical and Translational Research

PI, U01 CTSA Innovation Award, "Translational Workforce Training: Leveraging the Veterinary Specialist"

Coordinator, biennial Clinical Scientist Training Workshop for veterinary residents

Coordinator, Clinican Researcher curricular emphasis for DVM students at UW-SVM
 

Clinical Interests

Clinical pharmacology and therapeutics, particularly adverse drug reactions and drug interactions.
Small animal internal medicine, particularly hematology and hepatology.

Graduate Training

Member, Graduate faculties of Pharmaceutical Sciences, Molecular and Environmental Toxicology, and Comparative Biosciences

Video: Turning a Clinical Question into a Testable Hypothesis

Recent Publications

1. Luethcke KR, Ekena J, Chun R, Trepanier LA. Glutathione S-transferase theta genotypes and environmental exposures in the risk of canine transitional cell carcinoma. J Vet Intern Med,33:1414-1422, 2019. 

2. Ekena J, Wood E, Manchester A, Chun R, Trepanier LA. GST-theta genotypes and the risk of cyclophosphamide toxicity in dogs, Vet Comp Oncol16:529-534, 2018

3. 1. Reinhart J, Ekena J, Cioffi A, Trepanier LA. A single nucleotide polymorphism in the canine cytochrome b5 reductase (CYB5R3) gene is associated with sulfonamide hypersensitivity and is overrepresented in Doberman Pinschers. J Vet Pharmacol Ther 41:402-408,2018.
4.  Craft A, Ekena J, Mayer B, Thamm DH, Saba C, Chun R, Trepanier LA. Characterization of a low expression haplotype in canine glutathione-S-transferase (GSTT1) and its prevalence in golden retrievers. Vet Comp Oncol, 16:E61-E67, 2018.
6. Whitehouse W, Quimby J, Wan S, Monaghan K, Robbins R, Trepanier LA. Urinary F2 -Isoprostanes in Cats with International Renal Interest Society Stage 1-4 Chronic Kidney Disease.  J Vet Intern Med. 2017 Mar;31(2):449-456. doi: 10.1111/jvim.14634.
7. 1. Craft A, Ekena J, Sacco J, Luetchke, Trepanier LA. A 6 bp deletion variant in a novel canine glutathione-S-transferase gene (GSTT5) leads to loss of enzyme function. J Vet Intern Med31:183301840, 2017.

8. Wong YY, Johnson B, Friedrich TC, Trepanier LA. Hepatic expression profiles in retroviral infection: relevance to drug hypersensitivity risk. Pharmacol Res Perspect. 2017 Apr 26;5(3):e00312. 

15. 1.