Titles and Education
1. B.S. in Biology, St. Norbert College, 2010
2. Ph.D. in Comparative Biosciences, University of Wisconsin-Madison, 2014
3. Postdoctoral research in neurotoxicology, University of California-Davis, 2015-2019
Our lab is focused on understanding the impact of the environment on the establishment and regulation of urinary function. In particular, we are focused on developmental exposure to environmental contaminants. One environmental contaminant of interest includes polychlorinated biphenyls (PCBs). PCBs are ubiquitous environmental contaminants, and while they are known to have deleterious effects on the developing brain and central nervous system, their effects on the peripheral nervous system and peripheral target tissues - such as the bladder - are not understood. Therefore, we are using a combination of in vitro and in vivo approaches in mice to identify the effects of PCBs on urinary function focusing not only on bladder innervation and physiology but also on input from the central nervous system and dorsal root ganglia which are critical in controlling urinary function. Our ultimate goal is to be able to identify targets for therapeutic intervention and/or identify critical windows of exposure to help mitigate risk.
-Veterinary Toxicology (Course Director)
Comparative Biomedical Sciences
Molecular and Environmental Toxicology
Endocrinology and Reproductive Physiology
- Panesar HK, Kennedy CL, Keil Stietz KP*, Lein PJ*. (2020). Polychlorinated Biphenyls (PCBs): Risk Factors for Autism Spectrum Disorder?. Toxics. 17;8(3):E70. PMCID-in process. *Co-corresponding authorship.
- Matelski L, Keil Stietz KP, Sethi S, Taylor SL, Van de Water J, Lein PJ. (2020). The Influence of Sex, Genotype, and Dose on Serum and Hippocampal Cytokine Levels in Juvenile Mice Developmentally Exposed to a Human-Relevant Mixture of Polychlorinated Biphenyls. Current Research in Toxicology. 1:85-103. doi: https://doi.org/10.1016/j.crtox.2020.09.001.
Wang Z, Guzman EC, Nimunkar A, Keil KP, Vezina CM, Ricke WA, Macoska J, Bjorling DE (2019). Void Sorcerer: an Open Source, Open Access Framework for Mouse Uroflowmetry. Am J Clin Exp Urol. 7(3):170-177. PMCID - PMC6627548
Rude K, Pusceddu MM, Keogh CE, Sladek JA, Rabasa G, Miller EM, Sethi S, Keil KP, Pessah IN, Lein PJ, Gareau MG. (2019). Developmental exposure to polychlorinated biphenyls (PCBs) in the maternal diet causes host-microbe defects in weanling offspring mice. Environmental Pollution. 253:708-721.
Keil KP, Sethi S, Lein PJ. (2018). Sex differences in dendrite morphology in response to 2,2′,3,5′,6-pentachlorobiphenyl (PCB 95) in cultured primary mouse neurons. Tox Sci. doi: 10.1093/toxsci/kfy277
Keil KP, Sethi S, Wilson MD, Silverman JS, Pessah IN, Lein PJ. (2018). Genetic mutations in Ca2+ signaling alter dendrite morphology and social approach in juvenile mice. Genes Brain Behav. e12526. PMCID – PMC6540090
Sethi S, Keil KP, Lein PJ. (2018). 3,3ʹ-Dichlorobiphenyl (PCB 11) Promotes Dendritic Arborization in Primary Rat Cortical Neurons via CREB-Dependent Mechanisms. Arch Toxicol. 92(11):3337-3345. PMCID - PMC6196112.
Keil KP, Sethi S, Wilson MD, Chen H, Lein PJ (2017). Dendritic morphology varies between sexes in juvenile mice and in vitro models of neurodevelopment. Sci Rep. 7(1): 8486. PMCID – PMC5559594.
Wilson MD, Sethi S, Lein PJ, Keil KP. (2017). Valid statistical approaches for analyzing sholl data: mixed effects versus simple linear models. J. Neurosci Methods. 279:33-43. PMCID - PMC5346342
Ricke WA, Lee C, Clapper T, Schneider AJ, Moore RW, Keil KP, Abler LL, Wynder JL, Alvarado AL, Beaubrun I, Vo J, Bauman TM, Ricke EA, Peterson RE, Vezina CM (2016). In utero and lactational TCDD exposure increases susceptibility to lower urinary tract dysfunction in adulthood. Tox Sci. 50(2):429-40. PMCID - PMC26865671.
Keil KP, Abler LL, Altmann HM, Wang Z, Wang P, Ricke WA, Bjorling DE, Vezina CM. (2015). Impact of a folic acid enriched diet on lower urinary tract function in mice treated with testosterone and estradiol. Am J Physiol Renal Physiol. 308(12): 1431-43. PMCID - PMC4469891.