- O’Leary, K.A., D.E. Rugowski, M.P. Shea, R. Sullivan, A.R. Moser and L.A. Schuler. Prolactin synergizes with canonical Wnt signals to drive development of ER+ cancers via activation of the Notch pathway. Cancer Lett 503:231-239, 2021.
- Jallow, F., K.A. O’Leary, D.E. Rugowski, J.E. Guerrero, S.M. Ponik, and L.A. Schuler. Bidirectional interactions between the extracellular matrix and estrogen and antagonists, driving breast cancer progression, Oncogene 38: 6913-6915, 2019. Recognized by Extracellular Matrix News10.31 August 15, 2019, and Mammary Cell News 11.32 August 22, 2019; featured as Matrix Biology Highlight 87:8-9, 2020.
- Campbell, K.M., K.A. O’Leary, D.E. Rugowski, W.A. Mulligan, E.K. Barnell, Z.L. Skidmore, K. Krysiak, M. Griffith, L.A. Schuler, O.L. Griffith. Spontaneous aggressive ERα mammary tumor model is driven by Kras activation, Cell Reports 28:1526-1537, 2019. Recognized by Mammary Cell News11.31 August 15, 2019.
- Shea, M.P., K.A. O’Leary, S.A. Fakhraldeen, V. Goffin, A. Friedl, K.B. Wisinski, C.M. Alexander and L.A. Schuler. Anti-estrogen therapy increases plasticity and cancer stemness of prolactin-induced ERα+ mammary carcinomas. Cancer Res 78:1672-1684, 2018.
- Jallow, F., J.L. Brockman, K. Helzer, D. E. Rugowski, V. Goffin, E.T. Alarid, and L.A. Schuler. 17β-Estradiol and ICI 182,780 differentially regulate Stat5 isoforms in mammary epithelium, leading to distinct outcomes, J Endocr Soc 2:293-309, 2018.
- Shea, M.P., K.A. O’Leary, K.A. Wegner, C.M. Vezina, and L.A. Schuler. High collagen density augments mTOR-dependent cancer stem cells in ERα+ mammary carcinomas, and increases mTOR-independent lung metastases, Cancer Lett. 433:1-9, 2018.
- O’Leary, K.A., M.P. Shea, Salituro, C.E. Blohm and L.A. Schuler. Prolactin alters the mammary epithelial hierarchy, increasing progenitors and facilitating ovarian steroid action, Stem Cell Reports 9:1167–1179, 2017.
- Barcus C.E., K.A. O’Leary, J.L. Brockman, D.E. Rugowski, Y. Liu, N. Garcia, M. Yu, P.J. Keely, K.W. Eliceiri, L.A. Schuler. Elevated collagen-I augments tumor progressive signals, intravasation and metastasis of prolactin-induced estrogen receptor alpha positive mammary tumor cells. Breast Cancer Res 19:1-13, 2017.
- Morgan M.M., B.P. Johnson, M.K. Livingston, L.A. Schuler, E.T. Alarid, K.E. Sung, D.J. Beebe. Personalized in vitro cancer models to predict therapeutic response: Challenges and a framework for improvement. Pharmacol Ther, doi: 10.1016/j.pharmthera.2016.05.007
- Barcus C.E., P.J. Keely, K.W. Eliceiri, L.A. Schuler. Prolactin signals through focal adhesion complexes are increased by a stiff extracellular matrix environment in breast cancer cells, Oncotarget 7: 48093-48106, 2016. Top Story, Recognized by Extracellular Matrix News25 June 30, 2016
- O’Leary, K.A., M.P. Shea and L.A. Schuler. Modeling prolactin actions in breast cancer in vivo: insights from the NRL-PRL mouse. Adv. Expt. Med. Biol. 846:201-220, 2015.
- Barcus, C.E., E.C. Holt, P.J. Keely, K.W. Eliceiri, and L.A. Schuler. Dense collagen-I matrices enhance pro-tumorigenic estrogen-prolactin crosstalk in MCF-7 and T47D breast cancer cells. PLoS One. 2015 Jan 21;10(1):e0116891.
- Liu, Y., B.P. Johnson, A.L. Shen, J.A. Wallisser, K.J. Krentz, S.M. Moran, R. Sullivan, E. Glover, A.F. Parlow, N.R. Drinkwater, L.A. Schuler and C.A. Bradfield. Loss of Bmal1 in ovarian steroidogenic cells results in implantation failure in female mice, Proc. Natl. Acad. Sci. 111: 14295-14300, 2014. Highlighted in Nature Reviews Endocrinology 10:701, 2014.
- Arendt, L.M., D.E. Rugowski, T.A. Grafwallner-Huseth, M.J. Garcia-Barchino, H. Rui and L.A. Schuler. Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer, Breast Cancer Research 13:R11, 2011. Recognized by the weekly Mammary Cell News.
- O’Leary, K.A., D.E. Rugowski, R. Sullivan and L.A. Schuler. Prolactin cooperates with loss of p53 to promote claudin low mammary carcinomas. Oncogene 33:3075-3082, 2014.
- Asher, J.M., K.A. O’Leary, D.E. Rugowski, L.M. Arendt and L.A. Schuler. Prolactin promotes mammary pathogenesis independently from cyclin D1, Am. J. Pathol. 181:294-302, 2012.
- O’Leary, K.A., F. Jallow, D.E. Rugowski, R. Sullivan, K.W. Sinkevicius, G.L. Greene and L.A. Schuler. Prolactin activates ERα in the absence of ligand in female mammary development and carcinogenesis in vivo. Endocrinology 154:4883-4892, 2013.
- Barcus, C.E., P.J. Keely, K.W. Eliceiri and L.A. Schuler. Stiff collagen matrices increase tumorigenic prolactin signaling in breast cancer cells. J. Biol. Chem. 288:12722-12732, 2013. Highlighted in Matrix Biol. 32:iii-iv, 2013; Recognized by the weekly Extracellular Matrix News.
- Yu, Z., L-X.Zhao, C. Jiang, Y. Duan, L. Wong, K.C. Carver, L.A. Schuler and B. Shen. Bafilomycins produced by endophytic actinomyces Streptomyces YIM56209, J. Antibiotics, 16: 159-162, 2011.
- Schuler, L.A. and A.P. Auger. Psychosocially influenced cancer: diverse early-life stress experiences and links to breast cancer. Cancer Prev Res 3:1365-1370, 2010. (invited perspective)
- Sakamoto, K., A.A. Triplett, L.A. Schuler, K.-U. Wagner. Jak2 is required for the initiation but not maintenance of prolactin-induced mammary cancer, Oncogene 29: 5359-5369, 2010. Recognized by the weekly Mammary Cell News.
- Hasen, N.S., K.A. O’Leary, A.P. Auger and L.A. Schuler. Social isolation reduces mammary development, tumor incidence and expression of epigenetic regulators in wild type and p53-heterozygotic mice. Cancer Prev Res, 3:620-629, 2010.
- Carver, K.C., T.M. Piazza and L.A. Schuler. Prolactin enhances IGF-IR phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells. J. Biol. Chem., 285:8003-8012, 2010. Recognized by the weekly Mammary Cell News.
- Arendt, L.M., L.C. Evans, D.E. Rugowski, M.J. Garcia-Barchino, H. Rui, and L.A. Schuler. Ovarian hormones are not required for PRL-induced mammary tumorigenesis, but estrogen enhances neoplastic processes, J. Endocrinol. 203: 99-110, 2009. Cover feature.
- Regehr, K. J., M. Domenech, J.T. Koepsel, K. C. Carver, S. J. Ellison-Zelski, W. L. Murphy, L. A. Schuler, E. T. Alarid, and D. J. Beebe, Biological implications of polydimethylsiloxane-based microfluidic cell culture, Lab on a Chip 9: 2132-2139, 2009.
- Piazza, T.M., J-C. Lu, K.C. Carver and L.A. Schuler. Src family kinases accelerate prolactin receptor internalization, modulating trafficking and signaling in breast cancer cells. Mol. Endocrinol. 23: 202-212, 2009.
- Arendt, L.M., T.L. Grafwallner-Huseth, and L.A. Schuler. Prolactin and growth factor crosstalk reduces mammary estrogen responsiveness despite elevated ERα expression. Am. J. Pathol. 174:1065-1074, 2009.
- Carver, K.C., L.M. Arendt and L.A. Schuler. Complex prolactin crosstalk in breast cancer: new therapeutic implications. Mol. Cell. Endocrinol. 307: 1-7, 2009.
- Arendt, L.M. and L.A. Schuler. Transgenic models to study actions of prolactin in mammary neoplasia. J. Mammary Gland Biol. Neoplasia 13:29-40, 2008.
- Carver, K.C. and L.A. Schuler. Prolactin does not require insulin-like growth factor (IGF) intermediates, but synergizes with IGF-I in human breast cancer cells. Mol. Cancer Res. 6:634-643, 2008.
- Arendt, L.M. and L.A. Schuler. Prolactin drives ERα-dependent ductal expansion and synergizes with TGFα to induce mammary tumors in males. Am. J. Pathol. 172:194-202, 2008.
- Gutzman, J.H., D.E. Rugowski, S.E. Nikolai, L.A. Schuler. Stat5 activation inhibits prolactin-induced AP-1 activity: distinct prolactin initiated signals in tumorigenesis dependent on cell context, Oncogene 26:6341-6348, 2007.
- Rose-Hellekant, T.A., M.D. Schroeder, J.L. Brockman, O. Zhdankin, R. Bolstad, K.S. Chen, M.N. Gould, L.A. Schuler, E.P. Sandgren. Estrogen receptor positive mammary tumorigenesis in TGFα transgenic mice progresses with progesterone receptor loss, Oncogene 26:5238-5246, 2007.
- Carnes M, Schuler L, Sarto GE, Lent SJ, Bakken L. Increasing sex and ethnic/racial diversity of researchers in aging: some promising strategies at the postdoctoral level. J. Am. Geriatr. Soc. 54:980-5, 2006.
- Arendt, L.M., T.A. Rose-Hellekant, E.P. Sandgren and L.A. Schuler. Prolactin potentiates TGFα induction of mammary neoplasia in transgenic mice, Am. J. Pathol.,168:1365-1374, 2006.
- Lu, J-C., T.M. Piazza, and L.A. Schuler. Proteasomes mediate prolactin-induced receptor downregulation and fragment generation in breast cancer cells, J. Biol. Chem. 280: 33909-33916, 2005.
- Brockman, J.L. and L.A. Schuler. Prolactin signals via Stat5 and Oct-1 to the proximal Cyclin D1 promoter, Mol. Cell. Endocrinol. 239: 45-53, 2005.
- Gutzman, J.H., S.E. Nikolai, D.E. Rugowski, J.J. Watters and L.A. Schuler. Prolactin and estrogen enhance the activity of Activating Protein-1 in breast cancer cells: role of ERK1/2 mediated signals to c-fos, Mol. Endocrinol. 19: 1765-1778, 2005.
- Gutzman, J.H., D.E. Rugowski, M.D. Schroeder, J.J. Watters and L.A. Schuler. Multiple kinase cascades mediate prolactin signals to Activating Protein-1 in breast cancer cells, Mol. Endocrinol. 18: 3064-3075, 2004.
- Gutzman, J.H., K.K. Miller and L.A. Schuler. Endogenous hPRL and not exogenous hPRL induces ERα and PRLR expression and increases estrogen responsiveness in breast cancer cells, J. Steroid Biochem. Mol. Biol. 88:69-877, 2004.
- Clevenger, C.V., P. Furth, S. Hankinson, and L.A. Schuler. The role of prolactin in mammary carcinoma. Endocrine Reviews 24:1-27, 2003.
- Schroeder, M.D., J.L. Brockman, A.M. Walker, and L.A. Schuler. Inhibition of PRL induced proliferative signals in mammary tumor cells by a molecular mimic of phosphorylated PRL, S179D-PRL, Endocrinology 144:5300-5307, 2003.
- Rose-Hellekant, T.A., L.M. Arendt, M.D. Schroeder, K. Gilchrist, E.P. Sandgren and L.A. Schuler. Prolactin induces ERα positive and ERα negative mammary cancer in transgenic mice, Oncogene 22:4664-4674, 2003.
- Lu, J.-C., Scott, P., Strous, G.J., and L.A. Schuler. Multiple internalization motifs differentially used by prolactin receptor isoforms mediate similar endocytic pathways, Mol. Endocrinol. 16: 774-784, 2002.
- Schroeder, M., J. Symowicz, and L.A. Schuler. Prolactin modulates cell cycle regulators in mammary epithelial tumor cells, Mol. Endocrinol. 16:45-57, 2002.
- Brockman, J.L., M.D. Schroeder and L.A. Schuler. Prolactin stimulation of cyclin D1 transcription via the JAK-STAT pathway, Mol. Endocrinol. 16: 774-784, 2002.