Jorgensen Lab


Brown RM, Wang L, Fu A, Kannan A, Mussar M, Bagchi IC, Jorgensen JS. 2022 Irx3 Promotes Gap Junction Communication Between Uterine Stromal Cells to Regulate Vascularization During Embryo Implantation. Biol Reprod. doi: 10.1093/biolre/ioac015. PMID: 35138358.


Clapp Organski A, Jorgensen JS, Cross TWL. 2021 Involving the Life Inside: The Complex Interplay Between Reproductive Axis Hormones and Gut Microbiota. Current Opinion Endocr Met Res. 20:100284


Kothandapani A, Jefcoate CR, Jorgensen JS. 2021 Cholesterol contributes to male sex differentiation through its developmental role in androgen synthesis and hedgehog signaling. Endocrinology. 162:bqab066. PMID: 33784378.
– Chosen to be included in the Endocrine Society Thematic Issue on Lipids and Adipocytes 2021. Manuscript selections were guided by Altmetric Attention Scores and Featured Article designations.
– Featured as the Endocrinology Article of the Week for the week of July 12, 2021.


Kothandapani A, Larsen MC, Lee J, Jorgensen JS, Jefcoate CR. 2020 Distinctive Regulation and Functioning of STARD1 in the Fetal Testis in Relation to the Adult Adrenal Cortex and Testis. Hedgehog Signaling Controls Fetal Testis Activation Via the Primary Cilium. Mol Cell Endo. 531:111265.


Larsen MC, Lee J, Jorgensen JS, Jefcoate CR. 2020 StARD1 Functions in Mitochondrial Cholesterol Metabolism and Nascent HDL Formation. Gene Expression and Molecular mRNA Imaging Show Novel Splicing and a 1:1 Mitochondrial Association. Frontiers in Endocrinology. 11:559674. doi: 10.3389/fendo.2020.559674. PMID: 33193082.


Fu A, Koth ML, Brown RM, Shaw SA, Wang L, Krentz KJ, Zhang X, Hui CC, Jorgensen JS. 2020 IRX3 and IRX5 Collaborate During Ovarian Development and Follicle Formation to Establish Responsive Granulosa Cells in the Adult Mouse. Biol Reprod. 103(3):620-629. doi: 10.1093/biolre/ioaa100. PMID: 32507881.


Kothandapani A, Lewis SR, Muszynski JL, Zacharski A, Krellwitz K, Baines A, Winske S, Vezina CM, Kaftanovskaya EM, Agoulnik A, Merton EM, Cohn MJ, Jorgensen JS. 2020  GLI3 Resides at the Intersection of Hedgehog and Androgen Action to Promote Male Sex Differentiation. PLoS Genetics. 16(6):e1008810. doi: 10.1371/journal.pgen.1008810. PMID: 32497091.


Koth ML*, Garcia-Moreno SA*, Novak A, Holthusen KA, Kothandapani A, Jiang K, Taketo MM, Nicol B, Yao HHC, Futtner CR, Maatouk DM, Jorgensen JS. 2020  Canonical Wnt/b-catenin Activity and Differential Epigenetic Marks Direct Sexually Dimorphic Regulation of Irx3 and Irx5 in Developing Mouse Gonads. Development. 147(6): pii: dev183814. *co-first authors. PMID: 32108023.


Day JH, Nicholson TM, Su X, van Neel TL, Clinton I, Kothandapani A, Lee J, Greenberg MH, Amory JK, Walsh TH, Muller CH, Franco OE, Jefcoate CR, Crawford SE, Jorgensen JS, Theberge AB. 2020  Injection molded open microfluidic well plate inserts for user-friendly coculture and microscopy. Lab Chip. 20:107-119. doi: 10.1039/c9lc00706g.!divAbstract PMID: 31712791


 Fu A, Oberholtzer SM, Bagheri-Fam S, Rastetter RH, Holdreith C, Caceres VL, John SV, Shaw SA, Krentz KJ, Zhang X, Hui CC, Wilhelm D, Jorgensen JS. 2018  Dynamic Expression Patterns of Irx3 and Irx5 During Germline Nest Breakdown and Primordial Follicle Formation Promote Follicle Survival in Mouse Ovaries. PLoS Genetics. 14(8): e1007488. PMID: 30071018


 Jorgensen JS, Genovese RL, Döpfer D, Stewart MC.  2015  Musculoskeletal lesions and lameness in 121 horses with carpal sheath effusion (1999-2010). Vet Radiol Ultrasound. 53(3):307-16. doi: 10.1111/vru.12241. PMID: 25572121.


Jorgensen JS, Fu A, & Hornung M. 2018.  Female Sex Determination:Molecular. In M. K. Skinner (Ed.), Encyclopedia of Reproduction. vol. 2, pp. 57–64.Academic Press: Elsevier.


Carney CM*, Muszynski JL*, Strotman LN*, Lewis SR, O’Connell RL, Beebe DJ, Theberge AB,Jorgensen JS.  2014  Cellular Microenvironment Dictates Androgen Production By Murine Fetal Leydig Cells In Primary Culture. Biol. Reprod. 91(4):85.doi.114.118570.,%201-13/2434279 PMID: 25143354
* co-first authors;  co-corresponding authors


Lewis SR, Hedman CJ, Ziegler T, Ricke WA, Jorgensen JS.  2014  Steroidogenic Factor 1 promotes aggressive growth of castration resistant prostate cancer cells by stimulating steroid synthesis and cell proliferation.  Endocrinology.155(2):358-69. doi:10.1210/en.2013-1583 PMID: 24265454.
– Abstract featured on the Uro Today website, Tweeted by UW-Madison and The Prostate Post.


Jorgensen JS.  2013  Defining the neighborhoods that escort the oocyte through its early life events and into a functional follicle. Mol. Reprod. Dev., 80:960-976. PMID: 24105719. Selected for cover image.


Wainwright EN, Jorgensen JS, Kim Y, Truong V, Bagheri-Fam S, Davidson T, Svingen T, Fernandez-Valverde SL, McClelland KS, Taft RJ, Harley VR, Koopman P, Wilhelm D.  2013  SOX9 regulates microRNA miR-202-5p/3/ expression during mouse testis differentiation. Biol. Reprod. 89: 34, 1-12.,%201-12/2514043 PMID: 23843232.


 Kim B, Kim Y, Cooke PS, Rüther U, Jorgensen JS.  2011 The Fused Toes locus is essential for somatic-germ cell interactions that foster germ cell maturation in developing gonads. Biol Reprod 84:1024-1032. PMID: 21293032. Selected for calendar image, 2012 BOR calendar


 Kim B, Kim Y, Sakuma R, Hui CC, Rüther U, Jorgensen JS.  2011 Primordial germ cell proliferation is impaired in Fused Toes mutant embryos. Dev Biol 349:417-426. PMID: 20969841.


Gao L, Kim B, Kim Y, Lofgren SM, Schultz-Norton JR, Nardulli AM, Heckert LL, Jorgensen JS.  2011 Two regions within the proximal Sf1 promoter drive somatic cell-specific activity in developing gonads of the female mouse. Biol Reprod 84:422-434. PMID: 20962249.


Barsoum IB, Bingham NC, Parker KL, Jorgensen JS, Yao HHC 2009 Activation of the Hedgehog pathway in the mouse fetal ovary leads to ectopic appearance of fetal Leydig cells and female pseudohermaphroditism. Dev Biol 329(1):96-103. PMCID: PMC2673990