Golos Lab

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This animation is an MRI 4D Flow digital reconstruction of the maternal and fetal circulation of a Rhesus monkey during the third trimester of pregnancy : pink = umbilical chord, purple = chorionic vessels, orange and yellow = uterine vessels, large vertical green vessels = maternal circulation, the orange near the top = maternal kidneys, light blue = venous return, dark blue = fetal vessels and aortic arch, dark red = umbilical vein, green = fetal vena cava.  Image generated in collaboration with Oliver Wieben, PhD and Jacob MacDonald, Department of Radiology, UW Medical School, Madison.

 

Greetings from Dr. Ted Golos

I am a reproductive physiologist by training, and I have been working with nonhuman primates (NHPs) at the Wisconsin National Primate Research Center since 1987. During that time, my laboratory has made key strides forward in research with nonhuman primates and understanding the cellular and molecular biology of the maternal-fetal interface.

We have made a number of unique advances in this area, establishing methods for introducing genes into placental cells for molecular research, for introducing novel genes into the preimplantation embryo to study their impact on placental function, establishing stem cell models to understand the earliest stages of placenta formation, defining the transplantation antigen profile of the monkey placenta, assessing the function of these antigens in early pregnancy, and defining the immune cells in the uterine endometrium that are the likely collaborators in the establishment of a healthy and successful pregnancy.

Several years ago I decided to refocus our pregnancy research on establishing
bryce pregnancy imagetranslational models that could more directly address the critical role of the placenta in both maternal and fetal health, and we began to incorporate infectious disease studies into my laboratory. I also decided to leverage our embryology and stem cell expertise to develop strategically engineered primate models through the use of transgenesis and genomic editing with nonhuman primate assisted reproductive technologies. For information on research opportunities in the Golos lab, contact Ted Golos.