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Common Chemical Linked to Rare Birth Defect in Mice

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A chemical commonly used in consumer and agricultural products to boost the effectiveness of insecticides has been linked to a rare birth defect in mice. The chemical, piperonyl butoxide or PBO for short, is widely used as a “synergist” in household and agricultural insecticides to make the toxic effects of the insecticide longer lasting and to reduce the amount of actual insecticide in a product.
Despite its widespread and growing use, as well as its ubiquity in the environment, the chemical has been little studied. Now, a team led by Robert Lipinski, a professor of comparative biosciences in the University of Wisconsin–Madison’s School of Veterinary Medicine, reports that PBO interferes with the critical signaling pathway dubbed by scientists as sonic hedgehog, resulting in stunted forebrain development and signature facial abnormalities. The study is published this week (Oct. 23, 2019) in the journal Environmental Health Perspectives.  
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Newly Discovered Virus Infects Bald Eagles Across America

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Researchers have discovered a previously unknown virus infecting nearly a third of America’s bald eagle population. Scientists at the University of Wisconsin–Madison, the U.S. Geological Survey  National Wildlife Health Center and the Wisconsin Department of Natural Resources found …

UW–Madison, Local Startup Testing a One-Two Punch Against Hard-To-Heal Wounds

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Millions of people with severe burns or diabetic skin ulcers could benefit from an experimental enhancement to a next-generation covering that is already healing difficult wounds. A $1.5 million, two-year Small Business Innovation Research grant announced today will test whether adding gallium metal ions to an ultra-thin material carrying antimicrobial silver can defeat the “biofilms” that shield bacteria from antibiotics. Under the new grant, silver plus gallium will be tested on full-thickness wounds in the UW–Madison School of Veterinary Medicine.