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We have the capability to perform standard scotopic and photopic evaluation with Ganzfield illumination to estimate retinal function and to quantitate the retinal response to light stimulation. By using a flickering light source or patterned stimulus (Pattern Electroretinography) or by evaluating the waveform using computers to analyze the output, electroretinography can be used to assess different components of retinal function. Visual evoked potentials are made by recording the electrical activity of the visual cortex in response to visual stimuli allowing the investigator to estimate central processing function or even to estimate visual acuity. Additionally, multifocal electroretinography (MERG) can be performed to evaluate discrete function across large areas of the retina. Modern electrodiagnostic technology may provide the most sensitive test of retinal function and allow the establishment of a meaningful no effect level in retinal toxicity studies.
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