Education

•  DVM - Iowa State University, Ames, IA

  Rotating Internship - Sonora Veterinary Specialists, Phoenix, AZ

  PhD - University of Wisconsin-Madison, Madison, WI

  Oncology Residency - University of Wisconsin-Madison, Madison, WI

  Diplomate American College of Veterinary Internal Medicine (Oncology)

Research

My area of research is in the field of Wnt signaling abnormalities and their impact of cancer development and progression. Specifically, we are interested in the impact of Wnt signaling abnormalities in liver cancer, melanoma, and osteosarcoma. As a veterinary oncologist, I am interested in using spontaneously-occurring cancer in domestic animals as a model for human cancers, especially for osteosarcoma and malignant melanoma. My goal is to translate my findings in the animal models into improved therapies for both humans and animals. Additionally, my laboratory has experience in the use of transgenic mouse modeling and in the generation and characterization of primary cancer cell lines. Therefore, we are able to use a number of different systems to study the impact of aberrant Wnt signaling activity on osteosarcoma and malignant melanoma. Finally, should our findings be translatable into clinical therapeutics we have access to a natural model of human osteosarcoma, canine osteosarcoma, in which to carry out pre-clinical trials to benefit both populations.

Responsibilities

Research Committee Member

Residency Director - Medical Oncology
 

Clinical Interests

Osteosarcoma

Clincal and Translational Research

Graduate Training

Comparative Biomedical Sciences

Recent Publications

Figueiredo ML, Stein TJ, Jochem A, Sandgren EP. Mutant Hras and Kras have overlapping but non-identical effects on hepatocyte growth and transformation frequency in transgenic mice. Accepted Liver Int, Nov 2011.

Piskun CM, Muthuswamy A, Heulsmeyer MK, Thompson V, Stein TJ. Wnt/β-catenin expression does not correlate with serum alkaline phosphatase concentration in canine osteosarcoma patients. PLoS One, published online 11 Oct 11.

Webb JL, Friedrichs KR, Steinberg H, and Stein TJ. What is your diagnosis? Pleural effusion in a dog with hypertension. Vet Clin Path, Accepted October 2011.

Stein TJ, Bowden M, and Sandgren EP. Effect of H-ras overexpression in combination with c-myc or TGFα on liver growth homeostasis in transgenic mice. Liver Int 2011 31:1298-1305.

Stein TJ, Holmes KE, Jochem A, and Sandgren EP. Effect of mutant beta-catenin on liver growth homeostasis in transgenic mice. Liver Int 2011 31:303-312.

Stein TJ, Holmes KE, Muthuswamy A, Thompson V, and Huelsmeyer MK. Characterization of β-catenin expression in canine osteosarcoma. Vet Comp Oncol 2011 9:65-73.

Stein TJ, Pellin M, Steinberg H, and Chun R. Treatment of feline small cell gastrointestinal lymphoma with chlorambucil and glucocorticoids. J Am Anim Hosp Assoc 2010 46:413-417.

Lori J, Stein TJ, and Thamm D. Doxorubicin and cyclophosphamide for the treatment of canine lymphoma: a randomized, placebo-controlled study. Vet Comp Oncol 2010 8:188-195.