Timothy J Stein
Department of Medical Sciences
Office: 4372
Education
- DVM - Iowa State University, Ames, IA
- Rotating Internship - Sonora Veterinary Specialists, Phoenix, AZ
- PhD - University of Wisconsin-Madison, Madison, WI
- Medical Oncology Residency - University of Wisconsin-Madison, Madison, WI
- Diplomate American College of Veterinary Internal Medicine (Oncology)
Research
My area of research is in the field of Wnt signaling abnormalities and their impact of cancer development and progression. Specifically, we are interested in the impact of Wnt signaling abnormalities in liver cancer, melanoma, and osteosarcoma. As a veterinary oncologist, I am interested in using spontaneously-occurring cancer in domestic animals as a model for human cancers, especially for osteosarcoma and malignant melanoma. My goal is to translate my findings in the animal models into improved therapies for both humans and animals. Additionally, my laboratory has experience in the use of transgenic mouse modeling and in the generation and characterization of primary cancer cell lines. Therefore, we are able to use a number of different systems to study the impact of aberrant Wnt signaling activity on osteosarcoma and malignant melanoma. Finally, should our findings be translatable into clinical therapeutics we have access to a natural model of human osteosarcoma, canine osteosarcoma, in which to carry out pre-clinical trials to benefit both populations.
Responsibilities
Section Head - Medical Oncology
Residency Director - Medical Oncology
Co-Director - Center for Comparative Oral and Maxillofacial Pathology
Member - Carbone Cancer Center
Member - UW-Madison Institute for Clinical and Translational Research
Clinical Interests
Osteosarcoma
Clincal and Translational Research
Graduate Training
Comparative Biomedical Sciences
Recent Publications
Chon E, Thompson V, Schmid S, and Stein TJ. Activation of canonical Wnt/beta-catenin signaling pathway is rare in canine oral malignant melanoma tissue and cell lines. J Comp Pathol. 2012;12. Epub ahead of print.
Stein TJ, Bowden M, and Sandgren EP. Effect of H-ras overexpression in combination with c-myc or TGFβ on liver growth homeostasis in transgenic mice. Liver Int, 2011 31:1298-1305.
Stein TJ, Holmes KE, Jochem A, and Sandgren EP. Effect of mutant beta-catenin on liver growth homeostasis in transgenic mice. Liver Int 2011 31:303-312. PMCID:PMC3093768
Piskun CM, Muthuswamy A, Heulsmeyer MK, Thompson V, Stein TJ. Wnt/β-catenin expression does not correlate with serum alkaline phosphatase concentration in canine osteosarcoma patients. PLoS ONE 2011;6(10)e26106.
Stein TJ, Holmes KE, Muthuswamy A, Thompson V, and Huelsmeyer MK. Characterization of β-catenin expression in canine osteosarcoma. Vet Comp Oncol 2011 9:65-73. PMCID:PMC3099435