Department of Comparative Biosciences
- Assc. in Chemistry, Lake Superior State University, 1996
- B.S. in Biology, Lake Superior State University, 1996
- M.A. in Kinesiology, University of Texas at Austin, 1999
- Ph.D. in Kinesiology, University of Illinois-Chicago, 2004
My overall research interest is to determine how skeletal muscles sense mechanical information and convert this stimulus into the molecular events that regulate changes in muscle mass. This interest has led me to study a protein kinase called the mammalian target of rapamycin (mTOR). Signaling by mTOR is necessary for mechanically-induced growth of skeletal muscle, and I have recently determined that mechanical stimuli activate mTOR signaling through a unique mechanism involving phospholipase D and the lipid second messenger phosphatidic acid (PLD→PA→mTOR). Based on this observation, my lab has focused on three projects which are all aimed at further defining how mechanical stimuli activate the PLD→PA→mTOR pathway and skeletal muscle growth. To learn more about these projects, please visit the lab website:
To learn more about these projects, please visit the lab website:
- Principles of Vertebrate Physiology
You JS, Frey JW, and Hornberger TA. Mechanical Stimulation and Phosphatidic Acid Induce mTOR Signaling via an ERK-independent Mechanism. PLoS One, 2012 Oct 15:7(10):e47258.
Goodman CA, Miu MH, Frey JW, Mabrey DM, Lincoln HC, Ge Y, Chen J, Hornberger TA. A PI3K/PKB-Independent Activation of mTOR Signaling Is Sufficient to Induce Skeletal Muscle Hypertrophy. Mol Biol Cell. 2010 Sep;21(18):3258-68.
Goodman CA, Mabrey D, Frey JW, Miu MH, Schmidt EK, Pierre P, and Hornberger TA. Novel Insights into the Regulation of Skeletal Muscle Protein Synthesis as Revealed by a New Non-Radioactive In-Vivo Technique. FASEB J., 2011 Mar;25(3):1028-39
Goodman CA, Frey JW, Mabrey DM, Jacobs BL, Lincoln HC, You JS, and Hornberger TA. The Role of Skeletal Muscle mTOR in the Regulation of Mechanical Load-Induced Growth. J. Physiol, 2011 Nov 15;589(Pt 22):5485-501.
O'Neil TK, Duffy LR, Frey JW and Hornberger TA. The Role of Phosphoinositide 3-kinase and Phosphatidic Acid in the Regulation of mTOR following Eccentric Contractions. J. Physiol. 2009 May 26. [Epub ahead of print]