Department of Pathobiological Sciences
- Professor of Immunology
- DVM, Veterinary College, Univ. Agri. Sci. Bangalore, India
- MVSc., Veterinary College, Univ. Agri. Sci. Bangalore, India
- Ph.D, University of Minnesota, Twin Cities
- Postdoctoral Fellowship, Emory University School of Medicine, Atlanta, GA.
CD8 T cells play a critical role in defense against viral, intracellular bacterial, and protozoon infections. We are interested in studying the regulation of CD8 T-cell homeostasis during acute and chronic viral infections using the well-characterized mouse model of lymphocytic choriomeningitis virus (LCMV) infection. In an acute LCMV infection, the principal focus of our research is to understand the cellular and molecular basis of the generation of memory T cells. Specifically, we are interested in: 1) studying the role of direct effects of interferon gamma receptor signaling in regulating the survival and differentiation of memory T cells; 2) determining the role of cell cycle regulator p27Kip1 in differentiation of memory cells from effector CD8 T cells; 3) elucidating the importance of FOXO family of transcription factors in regulating memory CD8 T cell homeostasis. In a chronic LCMV infection, we are examining the role of p27Kip1 and E3 ubiquitin ligases in regulating functional responsiveness of virus-specific CD8 T cells.
Singh, A., A. Jatzek, E. H. Plisch, R. Srinivasan, J. Svaren, and M. Suresh (2010) Regulation of memory CD8 T cell differentiation by CDK inhibitor p27Kip1. Mol. Cell. Biol. (Accepted).
Hatta, Y, K. Hershberger, K. Shinya, S. C. Proll, R. D. Dubielzig, M. Hatta, M. G. Katze, Y. Kawaoka, and M. Suresh (2010) Viral replication rate regulates clinical outcome and CD8 T cell responses during highly pathogenic H5N1 Influenza virus infection. PLOS Pathogens. (Accepted).
Nakayama, Y., E. H. Plisch, J. A. Sullivan, C. J. Czuprynski, B. R. J. Williams, and M. Suresh (2010). PKR and Type I IFNs are dispensable for memory T cell expansion but required for viral control during primary and secondary infections. PLOS Pathog. 6(6):e1000966 Link.
Nakayama, Y., S. Kim, E. Kim, M. Sandor, and M. Suresh (2009) C3 promotes expansion of CD8+ and CD4+ T cells in a Listeria monocytogenes infection. J. Immunol. 183: 2921-31 Link.
Ito, Y., K. Shinya, M. Kiso, T. Watanabe, Y. Sakoda, M. Hatta, Y. Muramoto, D. Tamura, Y. Sakai-Tagawa, T. Noda, S. Sakabe, M. Imai, Y. Hatta, S. Watanabe, C. Li, S. Yamada, K. Fujii, S. Murakami, H. Imai, S. Kakugawa, M. Ito, R. Takano, K. Iwatsuki-Horimoto, M. Shimojima, T. Horimoto, H. Goto, K. Takahashi, A. Makino, H. Ishigaki, M. Nakayama, M. Okamatsu, K. Takahashi, D. Warshauer, P. A. Schult, R. Saito, H. Suzuki, Y. Furuta, M. Yamashita, K. Mitamura, K. Nakano, M. Nakamura, R. Brockman-Schneider, H. Mitamura, M. Yamazaki, N. Sugaya, M. Suresh, M. Ozawa, G. Neumann, J. Gern, H. Kida, K. Ogasawara, and Y. Kawaoka (2009) In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature: 460:1021-025 Link.
Nanjappa, S., J. Walent, and M. Suresh (2008) Alteration of CD8 T-cell memory by IL-7 is regulated by antigenic and bystander stimulation. J. Clin. Invest. Link.
Shamim, M., S. Nanjappa, A. Singh, S. LeBlanc, J. Svaren, C. Seroogy, and M. Suresh (2007) Cbl-b regulates antigen-induced TCR downregulation and IFN-gamma production by effector CD8 T cells without affecting functional avidity. J. Immunol. Link.
Singh, A and M. Suresh (2007) A Role for TNF in limiting the duration of CTL effector phase and magnitude of CD8 T-cell memory. J. Leuk. Biol. 82: 1201–1211 Link.
Singh, A., M. Wuthrich, B. Klein, and M. Suresh (2007) Indirect regulation of CD4 T-cell responses by TNF receptors during an acute viral infection. J. Virol. 81(12):6502-6512 Link.
Tewari, K., Y. Nakayama, and M. Suresh (2007) Role of direct effects of IFN-g on T cells in the regulation of CD8+ T cell homeostasis. J. Immunol. 179: 2115-2125 Link.
Tewari, K., J. Walent, J. Svaren, R. Zamoyska, and M. Suresh (2006). Differential requirement for p56Lck during activation of primary and memory CD8+ T cell responses. Proc. Natl. Acad. Sci. USA 103(44):16388-16393 Link.
Miller, N., J. Bonczyk, Y. Nakayama, and M. Suresh (2005) Role of thymic output in regulating CD8 T cell homeostasis during acute and chronic viral infection J. Virol. 79:9419-9429. Link
Kobasa, D., A. Takada, K. Shinya, P. Halfmann, M. Hatta, S Theriault, H. Suzuki, H. Nishimura, K. Mitamura, N. Sugaya,T. Usui, T. Murata, Y. Maeda, S. Watanabe, M. Suresh, T. Suzuki, Y. Suzuki, H. Feldmann, and Y. Kawaoka (2004) Enhanced pathogenicity of influenza A viruses possessing the haemagglutinin of the 1918 pandemic virus. Nature 431:703-707. Link
Suresh, M., C. Fischer, and A. Singh (2005) A role for tumor necrosis factor receptors in regulating CD8 T-cell responses during an acute lymphocytic choriomeningitis virus infection. J. Virol. 79(1):202-213. Link
Singh, A., J. Svaren, and M. Suresh (2004) CD8 T cell responses to lymphocytic choriomeningitis virus in early growth response gene 1-deficient mice. J. Immunol. 173(6):3855-3862. Link
Gao, X., K. Tewari, J. Svaren, and M. Suresh (2004) Role of cell cycle regulator E2F1 in regulating CD8 T cell responses during acute and chronic viral infection. Virol. 324(2):567-576. Link
Suresh, M., X. Gao, C. Fischer, N. E. Miller, and K. Tewari (2004) Dissection of antiviral and immune regulatory functions of tumor necrosis factor receptors in a chronic lymphocytic choriomeningitis virus infection. J. Virol. 78(8):3906-3918. Link
Tewari, K., J. Sacha, X. Gao, and M. Suresh (2004) Effect of chronic viral infection on epitope selection, cytokine production, and surface phenotype of CD8 T cells and the role of interferon gamma in immune regulation. J. Immunol. 172(3):1491-1500. Link
Suresh, M., H. Molina, M. S. Salvato, J. D. Lambris, and M. Sandor (2003) Complement component 3 is required for optimal expansion of CD8 T cells during a systemic viral infection. J. Immunol. 170(2):788-794. Link