Education

• Associate Professor of Immunology
• DVM, 1987, Veterinary College, Univ. Agri. Sci. Bangalore, India
• MVSc., 1990, Veterinary College, Univ. Agri. Sci. Bangalore, India
• Ph.D. 1995, University of Minnesota, Twin Cities
• Postdoctoral training, 1998, Emory University School of Medicine, Atlanta, GA.

Research

CD8 T cells play a critical role in defense against viral, intracellular bacterial, and protozoon infections. We are interested in studying the regulation of CD8 T-cell homeostasis during acute and chronic viral infections using the well-characterized mouse model of lymphocytic choriomeningitis virus (LCMV) infection. In an acute LCMV infection, the principal focus of our research is to understand the cellular and molecular basis of the generation of memory T cells. Specifically, we are interested in: 1) studying the role of direct effects of interferon gamma receptor signaling in regulating the survival and differentiation of memory T cells; 2) determining the role of cell cycle regulator p27Kip1 in differentiation of memory cells from effector CD8 T cells; 3) elucidating the importance of FOXO family of transcription factors in regulating memory CD8 T cell homeostasis.  In a chronic LCMV infection, we are examining the role of p27Kip1 and E3 ubiquitin ligases in regulating functional responsiveness of virus-specific CD8 T cells.

Recent Publications

Tewari, K., Y. Nakayama, and M. Suresh (2007) Role of direct effects of IFN-g on T cells in the regulation of CD8+ T cell homeostasis. J. Immunol. 179: 2115-2125. http://www.jimmunol.org/cgi/content/abstract/179/4/2115.

Nanjappa, S., J. Walent, and M. Suresh (2007) Alteration of CD8 T-cell memory by IL-7 is regulated by antigenic and bystander stimulation. J. Clin. Invest. (In Press).

Shamim, M., S. Nanjappa, A. Singh, S. LeBlanc, J. Svaren, C. Seroogy, and M. Suresh (2007) Cbl-b regulates antigen-induced TCR downregulation and IFN-g production by effector CD8 T cells without affecting functional avidity. J. Immunol. (Accepted).

Singh, A and M. Suresh (2007) A Role for TNF in limiting the duration of CTL effector phase and magnitude of CD8 T-cell memory. J. Leuk. Biol. 82: 1201–1211. www.jleukbio.org/cgi/content/abstract/82/5/1201

Singh, A., M. Wuthrich, B. Klein, and M. Suresh (2007) Indirect regulation of CD4 T-cell responses by TNF receptors during an acute viral infection. J. Virol. 81(12):6502-6512. http://jvi.asm.org/cgi/content/full/81/12/6502

Tewari, K., J. Walent, J. Svaren, R. Zamoyska, and M. Suresh (2006). Differential requirement for p56Lck during activation of primary and memory CD8+ T cell responses. Proc. Natl. Acad. Sci. USA 103(44):16388-16393 www.pnas.org/cgi/content/abstract/103/44/16388.

Miller, N., J. Bonczyk, Y. Nakayama, and M. Suresh (2005) Role of thymic output in regulating CD8 T cell homeostasis during acute and chronic viral infection J. Virol. 79:9419-9429. Link

Kobasa, D., A. Takada, K. Shinya, P. Halfmann, M. Hatta, S Theriault, H. Suzuki, H. Nishimura, K. Mitamura, N. Sugaya,T. Usui, T. Murata, Y. Maeda, S. Watanabe, M. Suresh, T. Suzuki, Y. Suzuki, H. Feldmann, and Y. Kawaoka (2004) Enhanced pathogenicity of influenza A viruses possessing the haemagglutinin of the 1918 pandemic virus. Nature 431:703-707. Link

Suresh, M., C. Fischer, and A. Singh (2005) A role for tumor necrosis factor receptors in regulating CD8 T-cell responses during an acute lymphocytic choriomeningitis virus infection. J. Virol. 79(1):202-213. Link

Singh, A., J. Svaren, and M. Suresh (2004) CD8 T cell responses to lymphocytic choriomeningitis virus in early growth response gene 1-deficient mice. J. Immunol. 173(6):3855-3862. Link

Gao, X., K. Tewari, J. Svaren, and M. Suresh (2004) Role of cell cycle regulator E2F1 in regulating CD8 T cell responses during acute and chronic viral infection. Virol. 324(2):567-576. Link

Suresh, M., X. Gao, C. Fischer, N. E. Miller, and K. Tewari (2004) Dissection of antiviral and immune regulatory functions of tumor necrosis factor receptors in a chronic lymphocytic choriomeningitis virus infection. J. Virol. 78(8):3906-3918. Link

Tewari, K., J. Sacha, X. Gao, and M. Suresh (2004) Effect of chronic viral infection on epitope selection, cytokine production, and surface phenotype of CD8 T cells and the role of interferon gamma in immune regulation. J. Immunol. 172(3):1491-1500. Link

Suresh, M., H. Molina, M. S. Salvato, J. D. Lambris, and M. Sandor (2003) Complement component 3 is required for optimal expansion of CD8 T cells during a systemic viral infection. J. Immunol. 170(2):788-794. Link

Gao, X., J. Svaren, and M. Suresh (2002) Role of cell cycle regulator p19ARF in regulating T cell responses. Cellular Immunol. 219(2):119-130. Link

Suresh, M., G. J. Lanier, M. K. Large, G. Lanier, J. K. Whitmire, J. D. Altman, N. H. Ruddle, and R. Ahmed (2002) Role of lymphotoxin a in T cell responses during an acute viral infection. J. Virol. 76(8):3943-3951. Link

Suresh, M., J. K. Whitmire, J. N. Blattman, C. P. Larsen, T. C. Pearson, J. D. Altman, and R. Ahmed (2001) Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory. J. Immunol. 167:5565-5573. Link