Education

• AB, Vassar College, 1985
• DVM, Washington State University, 1989
• Residency, Anesthesiology, Washington State University, 1989-1992
• Post-doctoral Fellow, Cardiac Physiology, Washington State University, 1992-1994
• Clinical Instructor, Small Animal Anesthesiology, University of Georgia, 1994-1995
• Clinical Instructor, Anesthesiology, Cornell University, 1995-1997
• Diplomate, American College of Veterinary Anesthesiologists, 1995
• Clinical Professor of Anesthesiology, University of Wisconsin Madison

Research

Dr. Smith's research interests are focused in the areas of acute and chronic pain management in companion animals and laboratory animals. She has received funding from the National Institutes of Health, the Morris Animal Foundation, and the UW Companion Animal Foundation. She has  published many papers on novel analgesic techniques or novel analgesic drugs or drug combinations in clinical patients as well as laboratory animals.  She is also interested in the analgesic effects and peripheral/central mechanisms of sodium channel blockers and GABA agonists/pathways in models of chronic neuropathic pain.

Responsibilities

Dr. Smith is involved in teaching students in the second, third, and fourth year veterinary curriculum. She coordinates the Fundamentals of Anesthesiology course, the Clinical Anesthesia rotation, and the Advanced Anesthesia elective in the students' fourth year.  Her teaching responsibilities are split between didactic teaching in lecture courses and instruction of fourth year students during their clinical rotations in anesthesiology. Dr. Smith is the faculty coordinator for the UW SVM residency program in Anesthesiology. She is also on the American College of Veterinary Anesthesiologists Board of Directors and currently serves as Chair. She also serves on many departmental and SVM committees and is the Section Head for Anesthesia.

Clinical Interests

Dr. Smith's clinical interests lie in the application of new approaches to pain management in companion animals. She has spoken at many national and international meetings in the areas of pain management and use of new anesthetic agents in veterinary medicine.

Recent Publications

Prior to promotion to Clinical Associate Professor at University of Wisconsin:
Refereed Papers
Savard R*, Smith LJ, Palmer JE, Greenwood MRC. Site specific effects of acute exercise on muscle and adipose tissue metabolism in sedentary female rats. Physiol and Behavior 1988, 43:65-71.

Grant B*., Smith LJ, Swenson K. et al. Hill training for high performance horses. Eq Athlete 1988, 1(1):6-15.

Smith LJ*, Greene SA, Moore MP, Keegan RD. The effects of varying arterial carbon dioxide tension on the quantitative electroencephalogram of halothane-anesthetized dogs. Am J Vet Res 1994, 55(4):467-471.

Smith LJ*, Stepien RL. Anesthesia Case of the Month. J Am Vet Med Assoc 1999, 214(3):340-343.

Smith LJ*, Moon PF, Lukasik VM, Erb HN. The duration of action and hemodynamic properties of mivacurium chloride in dogs anesthetized with halothane. Am J Vet Res 1999, 60(9): 1047-1050.

Smith LJ*, Schwark WS, Cook RD, Moon PF, Looney AL. The pharmacokinetic properties of intravenous mivacurium chlorine in dogs anesthetized with halothane. Am J Vet Res 1999, 60(9): 1051-1054.

Smith LJ*, Yu J Q-A. A Comparison of Epidural Buprenorphine with Epidural Morphine for Post-Operative Analgesia following Stifle Surgery in Dogs. Vet Anaesth Analg 2001, 28:87-96.

Smith LJ*, Yu J Q-A, Bjorling DE, Waller K. The effects of hydromorphone or oxymorphone, with or without acepromazine, on preanesthetic sedation, physiologic properties, and histamine release in dogs. J Am Vet Med Assoc 2001, 218(7):1101-1105.

Smith LJ*, Shih A, Miletic G, and Miletic V. Continual systemic infusion of lidocaine provides analgesia in an animal model of neuropathic pain. Pain 2002, 97:267-273.

Smith LJ*, Shih A, Miletic V. Preemptive administration of systemic lidocaine does not prevent hyperalgesia in the rat chronic constrictive injury model of neuropathic pain. Analgesia 2003 6:507-511.

After promotion to Clinical Associate Professor at University of Wisconsin:

Smith LJ*, Krugner-Higby L, Heath T, Clark M. A single dose of liposome-encapsulated oxymorphone or morphine provides long-term analgesia in an animal model of neuropathic pain. Comparative Medicine 2003 53(3):280-287.

Krugner-Higby L*, Smith LJ, Clark M, Heath TD, Dahly E, Schiffman B, Hubbard-VanStelle S, Ney D, Wendland A. Liposome-encapsulated oxymorphone hydrochloride provides prolonged relief of post-surgical visceral pain in rats. Comparative Medicine 2003 53(3):270-279.

Smith LJ*, Bentley E, Shih A, Miller PE. Systemic lidocaine infusion as a preemptive analgesic for intraocular surgery in dogs: a pilot study. Veterinary Anaesthesia and Analgesia 2004 31(1):53-64.

Smith LJ*, Krugner-Higby L, Trepanier LA, Flaska D, Joers V, Heath TD. Sedative effects and serum drug concentrations of oxymorphone and metabolites after subcutaneous administration of a liposome-encapsulated formulation in dogs. J Vet Pharmacol Therapeut 2004 27:1-4.

Clark MD, Krugner-Higby L*, Smith LJ, Heath TD, Clark KL, Olson D. Evaluation of liposome encapsulated (LE) oxymorphone hydrochloride in mice after splenectomy mice. Comparative Medicine, 2004 54(5):518-523.

Accola PJ, Bentley E*, Smith LJ, Forrest LJ, Baumel CA, Murphy CJ. Development of a retrobulbar injection technique for ocular surgery and analgesia in dogs. J Am Vet Med Assoc, 2006 229(2):220-225.

Smith LJ*, Valenzuela JR, Krugner-Higby L, Brown C, Heath TD. A single dose of liposome-encapsulated hydromorphone provides extended relief of hyperalgesia in a rodent model of neuropathic pain. Comparative Medicine, 2006 56(6):487-492.

Kukanich B, Hogan BK, Krugner-Higby LA, Smith LJ*. Pharmacokinetics of hydromorphone hydrochloride in healthy dogs. Vet Anesth and Analg, 2008 35:256-264.

Shih A, Miletic VA, Miletic G, Smith LJ*. Midazolam administration reverses thermal hyperalgesia and prevents GABA transporter loss in a rodent model of neuropathic pain. Anesthesia and Analgesia, 2008 106(4):1296-1302.

Smith LJ*, Kukanich B, Hogan BK, Brown C, Heath TD, Krugner-Higby L. Pharmacokinetics of a controlled-release liposome-encapsulated hydromorphone administered to healthy dogs. J Vet Pharmacol Therapeut, 2008, 31(5):415-422..

Kukanich B, Hogan BK, Krugner-Higby LA, Smith LJ*. Pharmcokinetics and behavioral effects of oxymorphone after intravenous and subcutaneous administration to healthy dogs. J Vet Pharmacol Therapeut, 2008, 31(6):580-583.

Sample SJ, Behan M, Smith L, Oldenhoff WE, Markel M, Kalscheur VL, Hao Z, Miletic V, Muir P*. Funtional adaptation to loading of a single bone is neuronally regulated and involves multiple bones. Submitted to J Bone Mineral Res, 2008, 23(9):1372-1381.

Krugner-Higby LA*, Kukanich B, Schmidt BK, Heath TD, Brown C, Smith LJ. Pharmacokinetics and behavioral effects of an extended release liposome-encapsulated preparation of oxymorphone in rhesus macaques. J Pharm Exp Ther, 2009 Jul;330(1):135-41.

After promotion to Clinical Professor at University of Wisconsin:

Krugner-Hibgy LA*, Kukanich B, Schmidt BK, Heath TD, Brown C, Smith LJ. Pharmacokinetics and behavioral effects of liposomal hydromorphone suitable for perioperative use in rhesus macaques. J Pharm Exp Ther, 2009; 330:135-141.

Myrna KE, Bentley E*, Smith LJ. Local anesthetic retrobulbar block reduces postoperative pain following enucleation of canine eyes: a randomized, placebo controlled, double-masked clinical trial. JAVMA, 2010 Jul 15;237(2):174-7.

Wunsch L, Krugner-Higby LA, Heath TD, Schmidt BK, Smith LJ*. A comparison of the effects of hydromorphone HCl and a novel extended release hydromorphone on arterial blood gas values in conscious healthy dogs. 2010 Res Vet Science; 88:154-8.

Schroeder CS, Smith LJ*. Evaluation of respiratory rates and arterial blood gas tensions in healthy rabbits premedicated with buprenorphine, butorphanol, midazolam, or their combinations. 2011 J Amer Assoc Lab Anim Sci; 50(2): 205-211.

Krugner-Higby LA*, Schmidt BK, Heath TD, Smith LJ. Experimental pharmacodynamics in laboratory beagles, and analgesic efficacy and side effects profile of liposome-encapsulated hydromorphone in dogs undergoing ovariohysterectomy. 2011 J Am An Hosp Assoc; 47(3):185-95.

Schmidt JR, Krugner-Higby L, Heath TD, Sullivan R, Smith LJ*. Epidural administration of ammonium sulfate gradient loaded liposomal hydromorphone provides 72 hours of analgesia in a rodent model of stifle arthritis. 2011 J Amer Assoc Lab Anim Sci; 50(4):507- 512.

Clark JS, Bentley E*, Smith LJ. Evaluation of topical nalbuphine or oral tramadol as analgesics for corneal pain in dogs: a pilot study, 2011 Vet Ophthal 14(6): 358 – 64.
Smith LJ*, Kukanich BK, Krugner-Higby LA, Schmidt BH, Heath TD. Pharmacokinetics of ammonium sulfate gradient loaded liposome-encapsulated oxymorphone and hydromorphone in healthy dogs. Submitted to Vet Anesth Analgesia, November 2011.
 

Book Chapters and Invited, Peer-reviewed Review Articles

Smith LJ, Moon PF. Anesthesia of Swine in Veterinary Clinics of North America; Food Animal Anesthesia, (C.E. Swanson, Ed.), W.B. Saunders, Philadelphia: November 1996.

Smith LJ. Hypotension: in Veterinary Anesthesia and Pain Management Secrets, (S.E. Greene, Ed.), Hanley & Belfus, Inc., Philadelphia: 2001.

Smith LJ. Clinical Toolbox: The importance of Pain Management. Veterinary Economics. 2004 2(9):7.

Smith LJ. Answering your questions: Practical Analgesia in cats. Veterinary Medicine, August 2005:602-610.

Smith LJ. On the Forefront: Extended-release liposomal opioids for treating pain in dogs. Veterinary Medicine, October 2005:708-711.

Smith LJ. Balanced Anesthetic Techniques. NAVTA Journal, Spring 2006.

Smith LJ. Liposome-encapsulated hydromorphone for extended analgesia in dogs. Leading Edge. Veterinary Forum, April 2007.

Krugner-Higby L, Smith LJ, Heath TD. Novel delivery systems for analgesic drugs in laboratory animals. In: Karas, A, Fish R, Danneman PJ, Brown M eds. Anesthesia and analgesia in laboratory animals. 2nd Edition. Spring 2007.

Schroeder CA, Smith LJ. Veterinary Anesthesia. In: McLoughlin TM, Johnson JO, Salinas FV eds. Advances in Anesthesia. Vol 29; Elsevier, Philadelphia PA. 2011 pp. 61-82.

Smith LJ. Novel Analgesic Delivery Methods. In: Egger C & Doherty T (editors). Pain Management in Veterinary Practice. 1st Edition. Wiley-Blackwell Publishing, Ames, IA. Spring 2012.