CBS Faculty Office: 4354B

• BS 1974, University of Wisconsin
• PhD 1980, University of Pennsylvania
• VMD 1981, University of Pennsylvania

Prolactin and related hormones modulate numerous processes which facilitate fetal development and maternal adaptations, including mammary gland development and lactation, as well as disease events in these same target tissues at other times in life. We are interested the determinants of cell and context specific actions, including ligand specificity, receptor signal transduction, receptor processing and cross talk with other signaling pathways. These areas allow us to examine hormonal, growth factor and cytokine interactions in the modulation of physiologic and pathogenic processes.  We are particularly interested in the action of prolactin on the mammary gland, and how it interacts with estrogenic and growth factor signals to increase the development and progression of breast cancer.

• The role of prolactin in mammary cancer
• Prolactin receptors, signaling and processing
• Prolactin actions on fetal and maternal tissues during pregnancy

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Graduate training and other affiliations