Peter Muir
Department of Surgical Sciences
Office: 4270B
Education
- Professor
- BVSc University of Bristol 1985
- MVetClinStud, The University of Sydney 1992
- PhD, University of Bristol 1990
- Membership of the Australian College of Veterinary Scientists in Small Animal Surgery 1992
- Membership of the American College of Veterinary Surgeons (Small Animal Surgery) 1995
- Membership of the European College of Veterinary Surgeons 1996
Research
Research interests are focused on skeletal adaptation to loading, stress (fatigue) fractures, long bone fracture repair, non-contact cruciate rupture in dogs, and canine arthritis. The Comparative Orthopaedic Research Laboratory has several major fields of interest, all applied to the musculoskeletal system.
In bone adaptation, the rodent ulna end-loading model is being used to examine the physiological mechanisms that regulate functional adaptation of the skeleton. Currently, my laboratory is particularly interested in the neural control of functional adaptation and whether plasticity in this regulatory system may be regulated by estrogen signaling.
My laboratory is also focused on obtaining a fundamental understanding of the mechanisms that lead to non-contact cruciate rupture in dogs. Currently, the laboratory is particularly interested in mapping the genetic basis for canine cruciate rupture, as well as studying the immune responses that lead to development of stifle synovitis. Synovitis is a key factor promoting ligament failure over time. We are also working on development of method for augmented primary cruciate repair in affected dogs. As, part of our clinical trial work in client-owned dogs, the laboratory has recently completed a trial studying model design for assessing efficacy of oral analgesic therapy for dogs with osteoarthritis.
Responsibilities
Teaching of small animal orthopaedic surgery and comparative orthopaedic science to veterinary students, veterinary surgery residents, and graduate students.
Clinical Interests
Small animal orthopaedic surgery, particularly fracture repair, treatment of dogs with non-contact cruciate rupture, and canine arthritis clinical trials.
Graduate Training
Comparative Biomedical Sciences Graduate Program trainer. Graduate students who recently completed PhDs include Susannah J Sample (2011), "Functional adaptation of the skeleton and the nervous system.' Current MS students include Jason Bleedorn, who is pursuing research entitled "Mechanically-induced signaling events during bone loading" for the MS degree and Sabrina Brounts, who is pursuing research entitled "Neuronal regulation of bone allograft remodeling and incorporation."
Recent Publications
Malek S, Sample SJ, Schwartz Z, Nemke B, Jacobson PB, Cozzi EM, Schaefer SL, Bleedorn JA, Holzman G, Muir P. Effect of analgesic therapy on outcome measures in client-owned dogs with knee osteoarthritis. BMC Veterinary Research 2012;8:185
Muir P, Schwartz Z, Malek S, Kreines A, Cabrera SY, Buote NJ, Bleedorn JA, Schaefer SL, Holzman G, Hao Z. Contralateral cruciate ligament survival in dogs with unilateral non-contact cranial cruciate ligament rupture. PLoS One 2011;6:e25331.
Muir P, Kelly JL, Marvel SJ, Heinrich DA, Schaefer SL, Manley PA, Tewari K, Singh A, Suresh M, Hao Z, Plisch EH. Lymphocyte populations in joint tissues from dogs with inflammatory stifle arthritis and degenerative cranial cruciate ligament rupture. Veterinary Surgery 2011;40
Bleedorn JA, Greuel EN, Schaefer SL, Manley PA, Hao Z, Markel MD, Holzman G, Muir P. Synovitis in stable stifle joints of dogs with incipient cranial cruciate ligament rupture: A cross-sectional study. Veterinary Surgery 2011;40:531-543.
Sample SJ, Behan M, Smith L, Oldenhoff WE, Markel MD, Hao Z, Kalscheur VL, Miletic V, Muir P. Functional adaptation to loading of a single bone is neuronally regulated and involves multiple bones. Journal of Bone and Mineral Research 2008;23:1372-1381.