Department of Comparative Biosciences
Ph.D., 1999, The University of Tokyo, Japan
D.V.M., 1995, The Ministry of Agriculture and Fishery, Japan
B.S., 1995, The University of Tokyo, Japan (Veterinary Medicine)
Application of stem cells to developmental modeling and cell-based therapy for neuromuscular disorders
Our long term objective is to apply stem cell technology to expand integrative sciences in both basic and translational research. The current research is to apply stem cell technology to disease modeling and therapeutic applications for neuromuscular disorders such as amyotrophic lateral sclerosis (ALS) and muscular dystrophy.
On the translational front, we are using human neural progenitor cells and mesenchymal stem cells as therapeutic applications for amyotrophic lateral sclerosis (ALS). The overall aim of our current idea is to provide growth factor delivery using stem cells to the spinal cord (i.e. cell body) and/or skeletal muscle (i.e. nerve terminals of motor neurons). We will establish whether stem cell and growth factor therapies can protect motor neurons from degeneration in a rat model of ALS.
Furthermore, we start a new research project to establish skeletal muscle stem cells using human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. This project is a part of the first project finding the best cells to transplant into the muscle for ALS and also will bring new therapeutic applications to other muscle diseases such as muscular dystrophy.
- Fundamental Principles of Veterinary Anatomy
Nichols NL, Gowing G, Satriotomo I, Nashold LJ, Dale EA, Suzuki M, Avalos P, Mulcrone P, McHugh J, Svendsen CN, Mitchell GS. Intermittent hypoxia and stem cell implants preserve breathing capacity in a rodent model of ALS. American Journal of Respiratory and Critical Care Medicine,
Hosoyama T, Meyer M, Krakora D, Suzuki M. Isolation and in vitro propagation of human skeletal muscle progenitor cells from fetal muscle. Cell Biology International, 37: 191-6, 2013.
Li R, Strykowski R, Meyer M, Mulcrone P, Krakora D, Suzuki M. Male-specific differences in proliferation, neurogenesis, and sensitivity to oxidative stress in neural progenitor cells derived from a rat model of ALS. PLoS ONE, 7: e48581, 2012.
Krakora D, Macrander C, Suzuki M. Neuromuscular junction protection for the potential treatment of amyotrophic lateral sclerosis. Neurology Research International, 379657, 2012.
Hayes-Punzo A, Mulcrone P, Meyer M, McHugh J, Svendsen CN, Suzuki M. Gonadectomy and dehydroepiandrosterone (DHEA) do not modulate disease progression in the G93A mutant SOD1 rat model of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis, 13: 311-14, 2012.