Jonathan McAnulty
Department of Surgical Sciences
Office: 2023
Education
- Current - Professor of Surgery, University of Wisconsin
- Chair, Department of Surgical Sciences
- DVM 1981, University of Georgia
- Internship 1982, Purdue University
- Surgical Residency 1985, University of Pennsylvania
- MS 1989, University of Wisconsin
- PhD 1994, University of Wisconsin
Research
Research in Dr. McAnulty's laboratory is currently focused on studies on engineering the molecular basis of wound surfaces for augmentation of healing and suppression or dissolution of bacterial biofilms from the wound surface. This work is focused on methods for attachment of various active molecules to the wound surface to alter the wound surface characteristics and properties at the nanoscale level. These studies involve a multilaboratory and multiinstitutional collaborative group and are funded by the National Institutes of Health. Other research involves studies on mechanisms of cellular injury during hypothermia and ischemia. These studies relate to both low temperature cardiopulmonary bypass methods and to organ preservation for transplantation. The thrust of this work is to reduce injury to organs stored for transplantation in order to reduce the incidence of delayed function and chronic allograft nephropathy as well as to increase the donor organ supply for human transplantation and to advance the field of veterinary transplantation.
Responsibilities
Administrative
Chair, Dept. of Surgical Sciences
Teaching
Small animal general surgery: lectures, labs
Clinical instruction in soft tissue surgery
Research
Nanoscale engineering of wound surfaces to promote healing
Clinically related projects
Organ preservation for transplantation
Research mentoring of residents and graduate students
Clinical Interests
Basic biology of wound healing and development of novel methods for stimulating non-healing wounds, plastic and reconstructive surgery, treatment of chylothorax and organ transplantation.
Graduate Training
Mentoring of residents in our small animal clinical surgical training program
Mentoring of graduate students in laboratory research
Recent Publications
Guthrie, K.M., Agarwal, A., Teixeira, L.B.C., Dubielzig, R.R., Abbott, N.L., Murphy, C.J., Singh, H., Schurr, M.J., McAnulty, J.F. Integration of silver nanoparticle-impregnated polyelectrolyte multilayers into murine splinted cutaneous wound beds. Journal of Burn Care and Research, In Press 2013.
Jain, R., Agarwal, A., Kierski, P.R., Schurr, M.J., Murphy, C.J.*, McAnulty, J.F., Abbott, N.L. The use of native chemical functional groups presented by wound beds enable covalent attachment of microbeads. Biomaterials, 34:340-352, 2013. PMID: 23088838; PMCID pending.
Agarwal A, Nelson T.B., Kierski P.R., Schurr M.J., Murphy C.J., Czuprynski C.J., McAnulty J.F., Abbott N.L.. Polymeric multilayers that localize the release of chlorhexidine from biologic wound dressings. Biomaterials 33:6783-92, 2012. PMCID: PMC3404134
Chattopadhyay S., Murphy C.J., McAnulty J.F., Raines R.T. Peptides that anneal to natural collagen in vitro and ex vivo. Organic and Biomolecular Chemistry 10: 5892-7, 2012. PMCID:PMC3395758
Guthrie K.M., Agarwal A., Tackes D.S., Johnson K.W., Abbott N.L., Murphy C.J., Czuprynski C.J., Kierski P.R., Schurr M.J., McAnulty.J.F. Antibacterial efficacy of silver-impregnated polyelectrolyte multilayers immobilized on a biological dressing in a murine wound infection model. Annals of Surgery, 256: 371-377, 2012. PMCID: PMC3433034