Education

• Professor
• BS 1981, University of California
• DVM 1983, University of California
• PhD 1990, Mayo Graduate School of Medicine

Research

Thermal modulation of musculoskeletal tissues; enhancement of fracture healing; cartilage resurfacing techniques; development of long bone fracture repair method. The Comparative Orthopaedic Research Laboratory has four major fields of interest, all within the musculoskeletal system. In the area of thermal modulation of musculoskeletal tissues, the laboratory has focused its efforts on developing techiques to enhance joint stability through the use of thermal shrinkage of joint capsular or ligamentous tissue. In addition, thermal heating of cartilage has been investigated attempting to balance potential beneficial effects of annealing chondromalacic cartilage versus the sudden death that may be caused by this technique. The laboratory is also focused on developing new techniques to enhance fracture healing including the investigation of morphogentic protein-2 combined with various carriers to enhance both normal and abnormal fracture healing. The third major area of focus for the laboratory is the development of cartilage resurfacing techniques using allograft neocratilage. The fourth major area for the laboratory is the development of new and better fracture fixation methods for long bone fractures in both small and large animals.

Responsibilities

Chair, Department of Medical Sciences; Associate Dean for Advancement; Musculoskeletal research; Large animal surgery.

Clinical Interests

Large animal surgery, specializing in orthopedics.

Recent Publications

Edwards RB, Lu Y, Cole BJ, Muir P, Markel MD: Comparison of radiofrequency treatment and mechanical debridement of fibrillated cartilage in an equine model.  VCOT 21:41-48, 2008.

Perrier M, Lu Y, Nemke B, Kobayashi H, Peterson A, Markel MD: Acceleration of second and fourth metatarsal fracture healing with recombinant human bone morphogenetic protein-2/calcium phosphate cement in horses. Vet Surg 37:648-655, 2008.

Lopez MJ, Lewis BP, Swaab ME, Markel MD: Relationships among measurements obtained by use of computed tomography and radiography and scores of cartilage microdamage in hip joints with moderate to severe joint laxity in dogs.  Am J Vet Res 69:362-370, 2008.

Lu Y, Meyer ML, Bogdanske JJ, Markel MD: The effects of radiofrequency energy probe speed and application force on chondrocyte viability. VCOT 20:34-37, 2007.

Edwards RB, Lu Y, Bogdanske JJ, Muir P, Markel MD: Comparison of mechanical debridement and radiofrequency energy for chondroplasty in an in vivo equine model of partial thickness cartilage injury. Osteoarthritis Cart 15:169-178, 2007.

Pluhar GE, Manley PA, Heiner JP, Vanderby R, Markel MD: Gluteal muscle attachment during proximal femoral reconstruction in a canine model. J Orthop Res 25:208-220, 2007

Lotto ML, Lu Y, Mitchell ME, Wright EJ, Lubowitz JH, Markel MD: The association of a char-like surface with underlying cell death during thermal chondroplasty. Arthroscopy 22:1159-1162, 2006.

Voss JR, Lu Y, Edwards RB, Bogdanske JJ, Markel MD: Effects of thermal energy on chondrocyte viability. Am J Vet Res 67:1708-1712, 2006.

Lu Y, Markel MD, Swain C, Kaplan LD: Development of partial thickness articular cartilage injury in an ovine model. J Orthop Res 24:1974-1982, 2006.

Uthamanthil RK, Edwards, RB, Manley PA, Athanasiou KA, Markel MD: In vivo study on the short-term effect of radiofrequency energy on chondromalacic patellar cartilage and its correlation with calcified pathology in an equine model. J Orthop Res 24:716-724, 2006.

Lopez MJ, Quinn MM, Markel MD: Evaluation of gait kinetics in puppies with coxofemoral joint laxity. Am J Vet Res 67:236-241, 2006.

Lu Y, Bogdanske J, Lopez, M, Cole BJ, Markel MD: Effect of simulated shoulder thermal capsulorraphy using radiofrequency energy on glenohumeral fluid temperature. Arthroscopy 21:592-596, 2005