Lauren Trepanier
latrepanier@svm.vetmed.wisc.edu
Department of Medical Sciences
Office: 4254
Education
- Professor, Internal Medicine
- B.S., The College of William and Mary, 1981
- D.V.M., Cornell University, 1986
- Internship and Residency in Small Animal Internal Medicine, The Animal Medical Center, NY, NY, 1986-1989
- Diplomate, ACVIM, 1991
- Ph.D., Pharmacology, Cornell University, 1997
- Diplomate, ACVCP, 1998
Research
Dr. Trepanier's research focuses on genetically determined differences in xenobiotic detoxification and their effect on individual and race/breed risks of adverse outcomes. The two major areas of research in her laboratory are: 1) the risk factors for sulfonamide drug hypersensitivity reactions in dogs and humans, and 2) the role of variation in gluthathione-S-transferases and cancer risk in dogs.
Responsibilities
Director, Clinician Scientist Training Programs
Director, Small Animal Internal Medicine Residency training program
Clinical Interests
Clinical pharmacology and therapeutics, particularly adverse drug reactions and drug interactions.
Small animal internal medicine, particularly hematology and hepatology.
Graduate Training
Member, Graduate faculties of Pharmaceutical Sciences, Molecular and Environmental Toxicology, and Comparative Biosciences
Video: Turning a Clinical Question into a Testable Hypothesis
Recent Publications
Ginn J, Sacco J, Wong YY, Motsinger-Reif A, Chun R, and Trepanier LA. Positive association between a glutathione-S-transferase (GSTT1) polymorphism and lymphoma in dogs. Vet Comp Oncol Epub Sep 29, 2012.
Sacco J, Abouraya M, Motsinger-Reif A, Yale S, McCarty C, Trepanier LA. Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity. Pharmacogenet Genom. 22:733-40, 2012.
Funk-Keenan J, Sacco J, Wong YY, Rasmussen S, Motsinger-Reif A, Trepanier LA. Evaluation of polymorphisms in the sulfonamide detoxification genes CYB5A and CYB5R3 in dogs with sulfonamide hypersensitivity. J Vet Intern Med. 6:1126-33, 2012.
Rhoads KM, Sacco JC, Drescher N, Wong A, Trepanier LA. Individual variability in the detoxification of carcinogenic arylhydroxylamines in human breast. Toxicol Sci. 121(2):245-56, 2011.
Abouraya M, Sacco JS, Kahl, BS, Trepanier LA. Evaluation of sulphonamide detoxification pathways in hematologic malignancy patients prior to intermittent trimethoprim-sulphamethoxazole prophylaxis. British J Clin Pharmacol, 71: 566-74, 2011.