Ted Golos

golos@primate.wisc.edu

Department of Comparative Biosciences
Office: 4354A

Education

• Marquette University, B.S., Biology, 1978
• University of Illinois at Urbana-Champaign, Ph.D., Physiology and Biophysics, 1984
• Postdoctoral training: Dept. of Obstetrics and Gynecology, Univ. of Pennsylvania, 1984-87

Research

My laboratory examines questions of placental biology relevant to human health and disease. We use both nonhuman primate models as well as human clinical materials in our studies.  Under this broad focus, research areas include

• maternal-fetal immune dialogue (nonpolymorphic MHC class I molecules on a subset of placental cells and their interactions with the maternal immune system),
• embryonic stem cells and primate embryos to model implantation and placental morphogenesis.

Our studies of embryo/maternal interactions will lead to improved understanding of the establishment and maintenance of pregnancy, reasons for early pregnancy loss, and insights into the role(s) of the placenta in promoting fetal well-being.  Appropriate placental development underpins appropriate fetal growth as well as maternal health and well-being. A detrimental intrauterine environment can profoundly affect postnatal physiology throughout the lifespan.  

 

Responsibilities

Professor

• Veterinary Histology 934:501 (Course Co-Director)

Graduate Training

• Endocrinology-Reproductive Physiology Training Program
• Cellular and Molecular Biology Training Program 
• Stem Cell and Regenerative Medicine Training Program
• Comparative Biomedical Sciences Training Program

Recent Publications

Dambaeva, S.V., Bondarenko, G.I., Grendell R.L., Kravitz, R.H., Durning, M., Golos, T.G. 2007 Nonclassical MHC-E (Mamu-E) expression in the rhesus monkey placenta. Placenta: in press.

Bondarenko, G., M. Durning, D. Burleigh, E. Breburda, R. Grendell, and T.G. Golos. 2007. Difficient placental growth, vascularization, and delayed endometrial responses to implantation in rhesus monkeys passively immunized in early pregnancy against a placental nonclassical MHC class I molecule, Mamu-AG. J. Immunol: in press.

Burleigh, D.W., C.M. Kendziorski, Y.J. Choi, K.M. Grindle, R.L. Grendell, R.R. Magness and T.G. Golos. 2006 Microarray analysis of BeWo and JEG3 trophoblast cell lines: identification of differentially expressed transcripts. Placenta 28(5-6): 383-9.

Breburda, E.E, S.V. Dambaeva, I.I. Slukvin and T.G. Golos.  2006 Selective distribution and pregnancy-specific expression of DC-SIGN at the maternal-fetal interface in the rhesus macaque: DC-SIGN is a putative marker of the recognition of pregnancy. Placenta 27(1): 11-21.

Liu, Y.P., O.V. Dovzhenko, M.A. Garthwaite, S.V. Dambaeva, M. Durning, L.M. Pollastrini, and T.G. Golos.  2004 Maintenance of pluripotency in human embryonic stem cells stably over-expressing enhanced green fluorescent protein.  Stem Cells and Development. 13: 636-645.

Gerami-Naini, B, O. Dovzhenko, M. Durning, F. Wegner, J. Thomson, and T.G. Golos. 2004 Trophoblast differentiation in embryoid bodies derived from human embryonic stem cells.  Endocrinology 145: 1517-1524.

Slukvin, I, E.E. Breburda, T.G. Golos.  2004 Dynamic changes in primate endometrial leukocyte populations: differential distribution of macrophages and natural killer cells at the rhesus monkey implantation site and in early pregnancy.  Placenta 25: 297-307.

Wolfgang M.J., S.G. Eisele, M.A. Browne, M.L. Schotzko, M.A. Garthwaite, M. Durning A. Ramezani, R.G. Hawley, J.A. Thomson and T.G. Golos. 2001 Rhesus monkey placental transgene expression after lentiviral gene transfer into preimplantation embryos. PNAS 98:10728-10732.

Grendell R.L., A.L. Hughes and T.G. Golos. 2001 Cloning of rhesus monkey killer-cell Ig-like receptors (KIRs) from early pregnancy decidua. Tissue Antigens 58:329-334.

Slukvin, I.I., D.P. Lunn, D.I. Watkins, and T.G. Golos. 2000. Placental expression of the nonclassical MHC class I molecule Mamu-AG at implantation in the rhesus monkey PNAS 97: 9104-9109.