Education

• Associate Professor
• DVM 1984, University Tennessee-Knoxville
• MS 1979, University of California-Davis

Research

Hemostasis and Microvascular Injury: - To investigate the mechanisms by which heparin oligosaccharides alter the function of inflammatory cells, and their effects on lung biology and pathology during infallation. Principal research project: - The interaction of heparin oligosaccharides in acute lung injury. Secondary research projects: - Ascending colon volvulus model of ischemia-reperfusion: Pathomorphologic and hemostatic changes. - Effects of Escherichia coli endotoxin on hemostasis in colostrum-fed calves.

Responsibilities

Large animal urinary, anemia and endocrinology; septic shock syndrome

Recent Publications

Darien, B.J., Sims, P.A., Stone, W.C., Schilly, D.A., Dubielzig, R.R., Albrecht, R.M. Ischemia/reperfusion injury of the ascending colon in ponies: A correlative study utilizing microvascular histopathology and corrosion casting. Scanning Microsc . 4:1311-1320, 1993.

Darien, B.J. Heparin therapy: Therapeutic rational and clinical indications. Comp. Contin. Educ. Pract. Vet. , 15(9):1273-1276, 1993.

Darien, B.J., Williams, M.A. Possible hypercoagulation in 3 foals with septicaemia. Equine Veterinary Education , 5:19-22, 1993.

Darien, B.J. Haemostatis -- A clinical review. Equine Veterinary Education , 5:33-36, 1993.

Darien, B.J. Hypercoagulation: Pathophysiology, diagnosis and treatment. Equine Veterinary Education , 5:37-40, 1993.

Darien, B.J., Sims, P.A., Kruse-Elliott, K.T., Homan, T.S., Cashwell, R.J., Albrecht, R.M. Use of colloidal gold and neutron activation in correlative microscopic labeling and label quantitation. Scanning Microsc. 9:773-780, 1995.

Darien, B.J., Stone, W.C., Dubielzig, R.R., Clayton, M.K. Morphologic changes of the ascending colon during experimental ischemia and reperfusion in ponies. Vet. Path , 32:280-288, 1995.