PBS
Faculty
Office: 4174 |  |
- BA 1976, Knox College
- PhD 1980, University of Wisconsin-Madison
- Postdoctoral Trainee, National Jewish Hospital, Denver CO 1980-1983.
- Professor in Microbiology
Immunoregulation of antibacterial resistance; immunotoxicology; bone marrow cells; cytokines; listeriosis; pasteurellosis; Haemophilus somnus; endothelial cells; Johne's disease; blastomycosis. The primary interest of our laboratory is studying mechanisms of resistance to bacterial infection. Under this broad heading major projects include: 1) Host, bacterial and environmental factors that influence the pathogenesis of gastrointestinal listeriosis; 2) Immunotoxicology – adverse effects of polycyclic aromatic hydrocarbons on bone marrow cells and hematopoiesis; 3) Bovine respiratory disease - focus on the effects of Mannheimia haemolytica and its leukotoxin on the activities of bovine leukocytes and lung cells; 4) Haemophilus somnus – adverse effects on bovine endothelial cells as it relates to vasculitis; 5) Paratuberculosis – invasion and intracellular growth of M. paratuberculosis in bovine macrophages.
Teach Veterinary Bacteriology and Mycology (PBS 517); supervise graduate students in immunology, microbiology and toxicology; Director of NIH Training Grant in Comparative Biomedical Sciences (provides research training to graduate veterinarians); PI of Summer Undergraduate Research Program in Molecular and Environmental Toxicology; Supervise Immunology Journal Club; member Executive Committee Food Research Institute
Recent and Current Graduate Students Name Degree Current position
Matt Sylte, DVM PhD Assist. Prof. Univ. GA
Fabio Leite, DVM PhD Assist. Prof. Univ. Pelotas
Steve Giles PhD Scientist, UW-Madison
Erica Behling-Kelly, DVM PhD Postdoc, Southwest. Med. Coll. Chris Kuckleburg PhD Postdoc, Univ. Birmingham, UK
Dhammika Atapattu, MD PhD Postdoc, UW-Madison
Lyndsey Berryman MS Nursing School, Marquette Univ.
Nicole Aulik PhD Candidate
Jose Garcia MS Candidate
Robert Sahaghian, DVM PhD Candidate
Faith, N., G. Uhlich, J. Luchansky, B. Neudeck, and C.J. CZUPRYNSKI. 2005. A prfA transposon mutant of Listeria monocytogenes F2365 (serotype 4b) is able to survive in the gastrointestinal tract but not cause systemic infection of the spleen and liver of intragastrically inoculated mice. Infect. Immun. 73:7517-7524.
Galvan, N., C. J. CZUPRYNSKI, and C. Jefcoate. 2006. Benzo(a)pyrene and 7,12-dimethylbez(a)anthracene differentially affect bone marrow cells of the lymphoid and myeloid lineages. Toxicol. Appl. Pharmacol. 213:105-116.
Kuckleburg, C. J., D. J. McClenahan, and C. J. Czuprynski. 2007. Platelet activation by Histophilus somni and its LOS induces endothelial cell pro-inflammatory responses and platelet internalization. Shock (in press).
Atapattu,. D., and C J. CZUPRYNSKI. 2007. Mannheimia haemolytica leukotoxin binds to lipid rafts in bovine lymphoblastoid cells (BL-3) and is internalized in a dynamin-2 and clathrin-dependent manner. Infect. Immun. (in press).
Woo , S.R., J. A Heintz, R. Albrecht , R. G Barletta, and C. J. CZUPRYNSKI. 2007. Life and death in bovine monocytes: the fate of Mycobacterium avium subsp. paratuberculosis. Microb. Pathogen. 43:106-113.