Education

• B.A. in Chemistry and Biology, St. Olaf College, 1998

• Ph.D. in Pharmacology and Toxicology, University at Buffalo, 2003

• Post-Doctoral research in Developmental Toxicology, 2003-2009.

Research

The Vezina lab uses the fetal mouse prostate as a model system to elucidate prostate growth stimulatory and inhibitory signals and investigate interactions between them in clinically relevant models of prostate disease. Our ultimate goal is to identify new pharmacological targets for prostate disease intervention. We are investigating how male hormones initiate prostate ductal formation, how prostate ducts elongate into surrounding mesenchyme, and how both of these processes are patterned in three dimensions to give rise to a bilaterally symmetrical prostate gland comprised of anterior dorsal, lateral, and ventral lobes.

VISIT THE VEZINA LAB WEBSITE

Responsibilities

Assistant Professor
• Pharmacology

Graduate Training

Molecular and Environmental Toxicology

Recent Publications

Vezina CM, Doles JD, Lipinski RJ, Peterson RE, Bushman W (2005). Comparative analysis of growth, morphogenesis, and differentiation during prostate development in vivo, in renal grafts, and in vitro. Prostate 65: 390-3999.

Vezina CM and Bushman W. (2007). Hedgehog signaling in prostate growth and benign prostate hyperplasia. Curr Prostate Rep 5: 27-32.

Vezina CM, Cook C, Hicks SM; Shaw A; Yu M; Peterson RE, Bushman W. (2007). Noggin is required for normal lobe patterning and ductal budding in the mouse prostate. Dev Biol 312: 217-230.

Vezina CM, Allgeier SH, Fritz WA, Moore RW, Strerath M, Bushman W, Peterson RE (2008). Retinoic Acid Induces Prostatic Bud Formation. Dev Dyn 237: 1321-33.

Allgeier SH, Lin T-M, Vezina CM, Moore RW, Fritz WA, Peterson RE. (2008). WNT5A Selectively Inhibits Mouse Ventral Prostate Development. Dev Biol 324:10-7.

Vezina CM, Allgeier S, Moore R, Lin T-M, Bemis J, Hardin HA, Gasiewicz T, Peterson R (2008). Dioxin causes ventral prostate agenesis by disrupting dorsoventral patterning in developing mouse prostate. Toxicol Sci 106: 488-96.

Vezina CM, Lin T-M, Peterson RE. AHR signaling in prostate growth, morphogenesis, and disease. Biochem Pharmacol 77: 566-576.

Allgeier SH, Vezina CM, Lin T-M, Moore RW, Silverstone AE, Mukai M, Gavalchin J, Cooke PS, Peterson RE. (2009). Estrogen signaling is not required for prostatic bud patterning or for its disruption by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. In Press.