Department of Comparative Biosciences
- Ph.D., 1983 - Zoology, University of California, Davis
- B.S., 1977 - Biological Sciences, State University of New York, Binghamton
Research in the Carey Laboratory uses hibernating mammals as models for adaptation to extreme changes in physiology and nutrition that occur on a seasonal basis, with a focus on the gastrointestinal tract and liver. Current studies in the laboratory are examining the symbiotic relationship between mammalian hibernators and their gut microbes.
Our laboratory also uses hibernators as models for identifying natural mechanisms for protection against stress and trauma conditions, including liver cold ischemia (e.g., during organ storage) and warm ischemia/reperfusion injury in gut and liver. These projects are designed to translate basic insights gained from the hibernation phenotype to improvements in human and animal biomedicine.
VISIT THE CAREY LAB
- Veterinary Physiology A: Renal Physiology
- Veterinary Physiology B: Gastrointestinal Physiology
- Comparative Biomedical Sciences Graduate Program
- Interdepartmental Graduate Program in Nutritional Sciences
- Department of Pediatrics-U.W. Madison
- Physiological Training Grant
Otis, J.P., D. Sahoo, V.A. Drover, C.L. Yen and H.V. Carey. 2011. Cholesterol and lipoprotein dynamics in a hibernating mammal. PLOS One 6:e29111.
Nelson, C.J., J.P. Otis, S.L. Martin and H.V. Carey. 2009. Analysis of the hibernation cycle using LC-MS based metabolomics in ground squirrel liver. Physiological Genomics 37:43-51.
Nelson, C.J., J.P. Otis and H.V. Carey. 2010. Global analysis of circulating metabolites in hibernating ground squirrels. Comp. Biochem. Physiol. Proteom Genomics 5: 265-273.
Nelson, C.J., Otis, J.P., and H.V. Carey. 2009. A role for nuclear receptors in mammalian hibernation. J. Physiol 587:1863-1870.
Carey, H.V., W.A. Walters and R. Knight. 2013. Seasonal restructuring of the ground squirrel gut microbiota over the annual hibernation cycle. Amer. J. Physiol. Regul. Integr. Comp. Physiol. 304: R33-R42.