Titles and Education

1. Ph.D., 1983 - Zoology, University of California, Davis
2. B.S., 1977 - Biological Sciences, State University of New York, Binghamton

Research

Research in the Carey Laboratory uses hibernating mammals as models for adaptation to extreme changes in physiology and nutrition that occur on a seasonal basis, with a focus on the gastrointestinal tract and liver.  Current studies in the laboratory are examining the symbiotic relationship between mammalian hibernators and their gut microbes.

Our laboratory also uses hibernators as models for identifying natural mechanisms for protection against stress and trauma conditions, including liver cold ischemia (e.g., during organ storage) and warm ischemia/reperfusion injury in gut and liver. These projects are designed to translate basic insights gained from the hibernation phenotype to improvements in human and animal biomedicine.

Responsibilities

Professor

• Veterinary Physiology A: Renal Physiology
• Veterinary Physiology B: Gastrointestinal Physiology

Director, UW-Biotron   biotron.wisc.edu/

Affiliate Positions:

• Department of Pediatrics-U.W. Madison

Graduate Training

Comparative Biomedical Sciences Training Program

Interdepartmental Graduate Program in Nutritional Sciences

Microbiology Doctoral Training Program

Recent Publications

1. Dill-McFarland, K.A., K. L. Neil, A. Zeng, R.J. Sprenger, C. C. Kurtz, G. Suen, and  H.V. Carey. 2014. Hibernation alters the diversity and composition of mucosa-associated bacteria while enhancing antimicrobial defence in the gut of 13-lined ground squirrels. Molecular Ecology 23: 4658–4669.

2. Hindle, A.G, Otis, J.P., Epperson, L.E., Hornberger, T.A., Goodman, C.A., Carey, H.V., and Martin, S.L.  2015. Prioritization of skeletal muscle regrowth for emergence from hibernation.  J Exp Biol 218: 276-84.

3. Dill-McFarland, K.A., G. Suen, and H.V. Carey. 2016. Bears arouse interest in microbiota's role in health. Trends in Microbiology 24: 245-246.

4. Kohl, K.D. and H.V. Carey. 2016. A place for the microbiome in the comparative physiologist’s toolbox.  J. Exp. Biol. 219: 3496-3504, 2016.

5. Dugbartey, G. J., M.C. Hardenberg, W.F. Kok, Boerema, A, H.V. Carey,  J.F. Staples, R. H. Henning and H.R. Bouma. 2017. Renal mitochondrial response to low temperature in non-hibernating and hibernating species. Antiox Redox Signal 27: 599-617.

6. Carey, H.V. and F.M. Assadi-Porter. 2017. The hibernator microbiome: host-bacterial interactions in an extreme nutritional symbiosis.  Annu Rev Nutr 37: 477-500.

7. Krautkramer, K.A., R.S. Dhillon, J.M. Denu and H.V. Carey. 2017. Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin.  Translational Research 189: 30-50.

8. Otis, J. P., A.C. Pike, J.R. Torrealba and H.V. Carey. 2017. Hibernation reduces cellular damage caused by warm hepatic ischemia-reperfusion in ground squirrels.  J Comp Physiol B 187:639–648.

9. Regan, M.D., E. Chiang, S.L. Martin, W.P. Porter, F.M. Assadi-Porter and H.V. Carey. 2019.  Hibernating ground squirrels shift metabolic fuel use during the early phase of arousal from torpor. Amer. J. Physiol. Regul. Integr. Comp. Physiol. doi: 10.1152/ajpregu.00379.2018