- Professor of Small Animal Surgery and Associate Dean for Research
- BS 1976, University of Illinois
- DVM 1978, University of Illinois
- Internship in Small Animal Medicine and Surgery 1978-79, University of California
- Residency in Small Animal Surgery 1979-82, University of Georgia
- MS 1982, University of Georgia
- Diplomate, American College of Veterinary Surgeons 1985
Inflammation of the bladder due to non-infectious causes, and mechanisms that modulate pain sensation and bladder healing. The laboratory's primary research emphasis is the causes and pathogenesis of non-infectious cystitis and and the effects of infectious cystitis on the afferent nervous system. Clinical disorders of particular relevance to models used in the laboratory include urinary tract infection, Interstitial Cystitis (IC) in women, and Feline Urologic Syndrome (FUS) in cats. The goals of this research are to identify processes that promote inflammation, damage, and pain within the bladder and to investigate improved therapeutic modalities for treatment or prevention of symptoms assocated with cystitis. Current research is focused specifically on the role of cannabinoid signaling in nociception associated with cystitis.
Currently serving as Associate Dean for Research and Graduate Training. In this capacity, directing summer research program for veterinary students and 12 month mentored research program for veterinary students.
General surgery: primarily the urinary tract, thorax, biliary tract.
Graduate students who recently completed PhDs and the titles of their dissertations include Jian Teng (2006), "The Effects of Steroid Hormones on Urothelial Cell Proliferation", Simon Guerios (2007), "Visceral Inflmmation and Somatic Pain Sensation", Fabiola Merriam (2009), "Role of Cannabinoids in Bladder Pain and Inflammation", and Sara Colopy (2012) "Ontogeny of Bladder Healing".
Teng J, Wang Z, Prossnitz ER, Bjorling DE. The G protein-coupled receptor GPR30 inhibits human urothelial cell proliferation. Endocrinology 2008;149: 4024-2034. PMC2488207
Murphy SM, Gutiérrez AN, Lawrence JE, Bjorling DE, Mackie TR, Forrest LJ. Laparoscopically implanted tissue expander radiotherapy (LITE-RT) in canine transitional cell carcinoma. Vet Radiol Ultrasound 2008;49:400-405.
Guerios SD, Wang Z, Boldon K, Bushman W, Bjorling DE. Blockade of NGF and trk receptors inhibits increased peripheral mechanical sensitivity accompanying cystitis in rats. Am J Physiol Regulat Integrat Compar Physiol 2008;295:R111-122. PMC2494812
Wang ZY, Wang P, Merriam FV, Bjorling DE. Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice. Pain 2008;139:158-167.
Merriam FV, Wang Z-Y, Guerios SD, Bjorling DE. Cannabinoid receptor 2 is increased in acutely and chronically inflamed bladder of rats. Neurosci Let 2008;445:130-134. PMC2592089
Guerios SD, Wang Z-Y, Boldon K, Bushman W, Bjorling DE. Lidocaine prevents referred hyperalgesia associated with cystitis. Neurourol Urodynam 2009;28:455-460. PMC2711218
Hardie RJ, Gunby J, Bjorling DE. Arytenoid lateralization for treatment of laryngeal paralysis in 10 cats. Vet Surg 2009;38:445-451.
Wang ZY, Wang P, Bjorling DE. Role of mast cells and protease-activated receptor-2 in cyclooxygenase-2 expression in urothelial cells. Am J Physiol Regul Integr Comp Physiol 2009;297:R1127-1135. PMC2763817
Merriam FV, Wang Z-Y, Hillard CJ, Stuhr KL, Bjorling DE. Inhibition of fatty acid amide hydrolase suppresses referred hyperalgesia induced by bladder inflammation. Brit J Urol Internat 2011;108:1145-1149. PMCID pending
Bjorling DE, Wang Z-Y, Bushman W. Models of lower urinary tract inflammation. Neurourol Urodynam 2011;30:673-682. PMC3113627
Murphy SM, Lawrence JA, Schmiedt CW, Davis KW, Lee FT Jr, Forrest LJ, Bjorling DE. Image guided transnasal cryoablation of a recurrent nasal adenocarcinoma in a dog. J Small Anim Pract 2011;52:329-333.
Wang Z-Y, Bjorling DE. Tumor necrosis factor-α induces expression and release of interleukin-6 by human urothelial cells. Inflam Res 2011;60:525-532. PMCID pending.
Saban MR, Davis CA, Avelino A, Cruz F, Maier J, Bjorling DE, Sferra TJ, Hurst RE, Saban R. VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG.
BMC Physiol 2011 Nov 7;11:16. PMC3226567.