As with dogs and cats, ~60% of Coccidioides immitis infections in humans are asymptomatic.

• These people are known to have been infected only by coccidioidin skin testing or serology.

However, chronic pulmonary disease (with thin-walled cavitation lesions in the lungs) and disseminated systemic disease (with bone involvement, meningitis, skin lesions and reproductive tract disease) can occur.

• Mortality from coccidioidomycosis is substantially increased during pregnancy.
• In addition, infections are more severe in individuals of certain blood types and HLA genotypes, reflecting the influence of host genetics on infectious disease outcomes.

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