Publications

24. Enomoto, A., Sandgren, E.P., and Maronpot, R.R. (1998). Interactive effects of c-myc and transforming growth factor a transgenes on liver tumor development in simian virus 40 T antigen transgenic mice. Vet. Pathol. 35:283-291.  [Abstract]
25. Enomoto, A., Sandgren, E.P., and Maronpot, R.R. (1998). Altered differentiation of hepatocytes in a transgenic mouse model of hepatocarcinogenesis. Toxicologic Pathol. 26:570-578.  [Abstract]
26. Egger, B., Carey, H.V., Procaccino, F., Chai, N.N., Sandgren, E.P., Lakshmanan, L., Buslon, V.S., French, S.W., Buchler, M.W., and Eysselein, V.E. (1998). Reduced susceptibility of mice overexpressing transforming growth factor alpha to dextran sodium sulphate induced colitis. Gut 43:64-70.  [Abstract]
27. Kisseberth, W.C., Brettingen, N.T., Lohse, J.K., and Sandgren, E.P. (1999). Ubiquitous expression of marker transgenes in transgenic mice and rats. Dev. Biol. 214:128-138.  [Abstract]    [Full Text]
28. Song, S.Y., Gannon, M., Washington, M.K., Scoggins, C.R., Meszoely, I.M., Goldenring, J.R., Marino, C.R., Sandgren, E.P., Coffey, R.J. Jr., Wright, C.V.E., and Leach, S.D. (1999). Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor a . Gastroenterol. 117:1416-1426.  [Abstract]
29. Jamal, H.Z., Weglarz, T.C., and Sandgren, E.P. (2000). Cryopreserved mouse hepatocytes retain regenerative capacity in vivo. Gastroenterol. 118:390-394.  [Abstract]    [Full Text]
30. Braun, K.M., Degen, J.L., and Sandgren, E.P. (2000). Hepatocyte transplantation in a model of toxin-induced liver disease: variable therapeutic effect during replacement of damaged parenchyma by donor cells. Nature Medicine 3:320-326.  [Abstract]    [Full Text]
31. Braun, K.M. and Sandgren, E.P. (2000). Cellular origin of regenerating parenchyma in a mouse model of severe hepatic injury. Am. J. Pathol. 157:561-569.  [Abstract]    [Full Text]
32. Grippo, P.J. and Sandgren, E.P. (2000). Highly invasive transitional cell carcinoma of the bladder in a simian virus 40 T-antigen transgenic mouse model. Am. J. Pathol. 157:805-813.  [Abstract]    [Full Text]
33. Weglarz, T.C., Degen, J.L., and Sandgren, E.P. (2000). Hepatocyte transplantation into diseased mouse liver: kinetics of parenchymal repopulation and identification of the proliferative capacity of tetraploid and octaploid cells. Am. J. Pathol. 157:1965-1978.  [Abstract]    [Full Text]
34. Weglarz, T.C. and Sandgren, E.P. (2000). Timing of hepatocyte entry into DNA synthesis after partial hepatectomy is cell autonomous. Proc. Natl. Acad. Sci. USA 97:12595-12600.  [Abstract]    [Full Text]
35. Herschman, H.R., MacLaren, D.C., Iyer, M., Namavari, M., Bobinski, K., Green, L.A., Wu, L., Berk, A.J., Toyokuni, T., Barrio, J.R., Cherry, S.R., Phelps, M.E., Sandgren, E.P., and Gambhir, S.S. (2000). Seeing is believing: Non-invasive, quantitative and repetitive imaging of reporter gene expression in living animals, using positron emission tomography. J. Neurosci. Res. 59:699-705.  [Abstract]
36. Schroeder, M.D., Rose-Hellekant, T., Sandgren, E.P., and Schuler, L.A. (2001). Dysregulation of mammary STATS 1, 3, and 5 and PRL receptors by overexpression of TGFa.  Mol. Cell Endocrinol.  175:173-83.   [Abstract]   [Full Text]
37. Kim, S., Zeller, K., Dang, C.V., Sandgren, E.P., and Lee, L.A.  (2001).  A strategy to identify differentially expressed genes using representational difference analysis and cDNA arrays.  Anal Biochem.  288: 141-148.   [Abstract]
38. Yen, T.W.F., Sandgren, E.P., Liggitt, H.D., Palmiter, R.D., Zhou, W., Hinds, T.R., Grippo, P.J., McDonald, J.M., Robinson, L.M., and Bell, R.H., Jr.  (2001).  The gastrin receptor promotes pancreatic growth in transgenic mice.  Pancreas.  in press.  [Abstract]

Manuscripts in Preparation:

39. Rose-Hellekant, T.R., Gilchrist, K., and Sandgren, E.P.  (submitted).  Genetic strain background alters mammary gland phenotype in TGFa transgenic mice.
40. Weglarz, T.C., and Sandgren, E.P.  (in preparation).  PPARa-independent hepatocyte replication after exposure to peroxisome proliferator in receptor-chimeric mouse liver.
41. Kisseberth, W.C., and Sandgren, E.P.  (in preparation).  Polyclonal origin of mouse mammary hyperplastic alveolar nodules.
42. Kisseberth, W.C., Luetteke, N.C., Lee, D.C., and Sandgren, E.P.  (in preparation).  Cleavage-resistant pro-TGFa induces mammary gland adenocarcinomas but not cysts in transgenic mice.
43. Rose-Hellekant, T.R., et al.  (in preparation).  TGFa-induced mammary neoplasia in a transgenic mouse model using a hormonally non-responsive gene targeting element.
44. Grippo, P.J., Figueiredo, M.L., and Sandgren, E.P.  (in preparation).  Expression of mutant ras proteins induces acinar-ductal metaplasia and ductal carcinoma in transgenic mouse pancreas.
45. Braun, K.M., and Sandgren, E.P.  (in preparation).  Hepatic microenvironment affects oval cell localization in AL-uPA transgenic mice.

Invited Reviews:

4. Braun, K.M., and Sandgren, E.P. (1998). Liver disease and compensatory growth: unexpected lessons from genetically altered mice. Int. J. Dev. Biol. 42:935-942.  [Abstract]    [Full Text]
5. Rose-Hellekant, T.A., and Sandgren, E.P. (2000). Transforming growth factor alpha- and c-myc-induced mammary carcinogenesis in transgenic mice. Oncogene 8:1092-1096.  [Abstract]    [Full Text]
6. Kisseberth, W.C., and Sandgren, E.P. (2000). Building a better mouse: Animal models of human disease for gene therapy. In Kresina, T., ed. An Introduction to Gene Therapy and Molecular Medicine.  John Wiley and Sons.
7. Figueiredo, M.L., and Sandgren, E.P. (in press).  Novel Strategies for Manipulating Gene Expression in vivo.  In Arias, I., et al., eds. The Liver: Biology and Pathobiology.  4^th ed.  New York: Raven Press.