MICHAEL T. COLLINS
Professor of Microbiology
BS 1970, University of Minnesota
DVM 1972, University of Minnesota
PhD 1976, University of Georgia
Diplomate, American College of Veterinary Microbiologists
Principal Research Interests
Paratuberculosis (Johne's disease) and the biology of its causative agent,
Mycobacterium paratuberculosis. (electron micrograph,
Johne's disease is a prevalent, costly, infectious disease affecting
dairy cattle and other ruminants. Improving methods of detecting the disease
is the primary focus of the laboratory. In collaboration with other investigators,
the diagnostic techniques available in our laboratory are used to study
the epidemiology, economic impact, zoonotic potential, and pathogenesis
of the disease in a variety of species (cattle, goats, llamas, etc). This
has led to an increased volume of clinical submissions to the laboratory.
In 1995 over 20,000 serum and 5,000 fecal samples were processed for diagnosis
and control of Johne's disease. Another focus of the laboratory is investigation
of the relationship between Crohn's disease, a chronic inflammatory bowel
disease in humans, and M. paratuberculosis. In addition to diagnostic
services, the laboratory provides information and education through telephone
consultation, herd visits, veterinary and producer presentations, lay publications,
and a Johne's Information Center on the World
Areas of Teaching Responsibility
Last revised February 19, 1997.
Sockett, D.C., Carr, D.J., Collins, M.T. Evaluation of conventional and
radiometric fecal culture and a commercial DNA probe for diagnosis of Mycobacterium
paratuberculosis infections in cattle. Can. J. Vet. Res. 56:148-153.
Collins, M.T. and Sockett, D.C. Accuracy and economics of the USDA-licensed
enzyme-linked immunosorbent assay for bovine paratuberculosis. J. Am
Vet Med Assoc . 203:1456-1463, 1993.
Collins, M.T., Sockett, D.C., Goodger, W.J., et al. Herd prevalence, geographic
distribution of, and risk factors for, bovine paratuberculosis in Wisconsin.
J Am Vet Med Assoc . 204:636-641, 1994.
Collins, M.T. Clinical approach to control of bovine paratuberculosis.
J Am Vet Med Assoc. 204: 208-210, 1994.
Lambrecht, R.S., Collins, M.T. Inability to detect mycobactin in Mycobacteria-infected
tissues suggests an alternative iron acquisition mechanisms by Mycobacteria
in vivo . Microbial Pathogenesis 1993;14:229-238.
Collins, M.T., Morgan, I.R. Simulation model of paratuberculosis control
in a dairy herd. Prev Vet Med 1992;14:21-32.
URL is http://www.vetmed.wisc.edu/pbs/johnes/mtc.html.
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