Publications by Tom Friedrich
Peer-reviewed publications
  • Budde ML, Greene JM, Chin EN, Ericsen AJ, Scarlotta M, Cain BT, Pham NH, Becker EA, Harris M, Weinfurter JT, O’Connor SL, Piatak M, Lifson JD, Gostick E, Price DA, Friedrich TC, O’Connor DH (2012). Specific CD8+ T cell responses correlate with control of SIV replication in Mauritian cynomolgus macaques. J Virol. in press.
  • Becker EA, Burns CM, Leon EJ, Rajabojan S, Friedman R, Friedrich TC, O’Connor SL, Hughes AL (2012). Experimental sources of error in evolutionary studies based on Roche/454 pyrosequencing of viral genomes. Genome Biol Evol. 4:457-65.
  • Bearden EA, Friedrich TC, Goldberg TL, Byrne B, Spiegel C, Schult P, Safdar N (2012). An outbreak of the 2009 influenza A (H1N1) virus in a children’s hospital. Influenza Other Respi Viruses in press.
  • O'Connor SL, Becker EA, Weinfurter JT, Chin EN, Budde ML, Gostick E, Correll M, Gleicher M, Hughes AL, Price DA, Friedrich TC, O'Connor DH (2011). Conditional CD8+ T cell escape during acute simian immunodeficiency virus infection. J Virol 86:605-9.
  • Watanabe T, Shinya K, Watanabe S, Imai M, Hatta M, Li C, Wolter BF, Neumann G, Hanson A, Ozawa M, Yamada S, Imai H, Sakabe S, Takano R, Iwatsuki-Horimoto K, Kiso M, Ito M, Fukuyama S, Kawakami E, Gorai T, Simmons HA, Schenkman D, Brunner K, Capuano SV, Weinfurter JT, Nishio W, Maniwa Y, Igarashi T, Makino A, Travanty EA, Wang J, Kilander A, Dudman SG, Suresh M, Mason RJ, Hungnes O, Friedrich TC, Kawaoka Y (2011). Avian-type receptor-binding ability can increase influenza virus pathogenicity in macaques. J Virol 85:13195-203.
  • Weinfurter, JT, Brunner K, Capuano SV, Li C, Broman K, Kawaoka Y, Friedrich TC (2011). Cross-reactive T cells are involved in rapid clearance of 2009 pandemic H1N1 influenza virus in nonhuman primates. PLoS Pathogens 7:e1002381
  • Mudd PA, Ericsen AJ, Walsh AD, León EJ, Wilson NA, Maness NJ, Friedrich TC, Watkins DI (2011). CD8+ T cell escape mutations in simian immunodeficiency virus SIVmac239 cause fitness defects in vivo and many revert after transmission. J Virol 85:12804-10.
  • Reynolds MR, Sacha JB, Weiler AM, Borchardt GJ, Glidden CE, Sheppard NC, Norante FA, Castrovinci PA, Harris JJ, Robertson HT, Friedrich TC, McDermott AB, Wilson NA, Allison DB, Koff WC, Johnson WE, Watkins DI (2011). TRIM5-alpha genotype of rhesus macaques affects acquisition of SIVsmE660 infection after repeated limiting-dose intrarectal challenge. J Virol 85:9637-40.
  • Lauck M, Hyeroba D, Tumukunde A, Weny G, Lank SM, Chapman CA, O'Connor DH, Friedrich TC, Goldberg TL (2011). Novel, divergent simian hemorrhagic fever viruses in a wild Ugandan red colobus monkey discovered using direct pyrosequencing. PLoS ONE 6(4):e19056.
  • Weinfurter JT, May GE, Soma T, Hessell AJ, León EJ, Mac Nair CE, Piaskowski SM, Weisgrau K, Furlott J, Maness NJ, Reed J, Wilson NA, Rakasz EG, Burton DR, Friedrich TC (2011). Macaque long-term nonprogressors resist superinfection with multiple CD8+ T cell escape variants of simian immunodeficiency virus. J Virol 85:530-41.
  • Reynolds MR, Piaskowski SM, Weisgrau KL, Weiler AM, Friedrich TC, Rakasz EG (2010). Ex vivo analysis of SIV-infected cells by flow cytometry. Cytometry A 77:1059-66.
  • Friedrich TC, Piaskowski SM, León EJ, Furlott JR, Maness NJ, Weisgrau KL, MacNair CE, Weiler AM, Loffredo JT, Reynolds MR, Williams KY, Klimentidis YC, Wilson NA, Allison DB, Rakasz EG (2010). High viremia is associated with high levels of in vivo MHC-I downregulation in rhesus macaques infected with SIVmac239. J Virol 84:5443-7.
  • O’Connor SL, Lhost JJ, Becker EA, Detmer AM, Johnson RC, MacNair CE, Wiseman RW, Karl JA, Greene JM, Burwitz BJ, Bimber BN, Lank SM, Tuscher JJ, Mee ET, Rose NJ, Desrosiers RC, Hughes AJ, Friedrich TC, Carrington M, O’Connor DH (2010). MHC heterozygote advantage in simian immunodeficiency virus-infected Mauritian cynomolgus macaques. Science Transl Med 2:22ra18.
  • Greene JM, Lhost JJ, Burwitz BJ, Budde ML, MacNair CE, Weiker MK, Gostick E, Friedrich TC, Broman KW, Price DA, O'Connor SL, O'Connor DH (2010). Extralymphoid CD8+ T cells resident in tissue from simian immunodeficiency virus SIVmac239∆nef-vaccinated macaques suppress SIVmac239 replication ex vivo. J Virol 84:3362-72.
  • Valentine LE, Loffredo JT, Bean AT, León EJ, MacNair CE, Beal DR, Piaskowski SM, Klimentidis YC, Lank SM, Wiseman RW, Weinfurter JT, May GE, Rakasz EG, Wilson NA, Friedrich TC, O’Connor DH, Allison DB, Watkins DI (2009). Infection with “escaped” virus variants impairs control of simian immunodeficiency virus SIVmac239 replication in Mamu-B*08-positive macaques. J Virol 83:11514-27.
  • Sacha JB, Giraldo-Vela JP, Buechler MB, Martins MA, Maness NJ, Chung C, Wallace LT, León EJ, Friedrich TC, Wilson NA, Hiraoka A, Watkins DI (2009). Gag- and Nef-specific CD4+ T cells recognize and inhibit SIV replication in infected macrophages early after infection. Proc Natl Acad Sci USA 106:9791-6.
  • Wilson NA, Keele BF, Reed JS, Piaskowski SM, Mac Nair CE, Bett AJ, Liang X, Wang F, Thoryk E, Heidecker GJ, Citron MR, Huang L, Lin J, Vitelli S, Ahn CD, Kaizu M, Maness NJ, Reynolds MR, Friedrich TC, Loffredo JT, Rakasz EG, Erickson S, Allison DB, Piatak M Jr, Lifson JD, Shiver JW, Casimiro DR, Shaw GM, Hahn BH, Watkins DI (2009). Vaccine-induced cellular responses control SIV replication after heterologous challenge. J Virol 83:6508-21.
  • Reynolds MR, Weiler AM, Weisgrau KL, Piaskowski SM, Furlott JR, Soma T, Gostick E, Musani SK, Price DA, Friedrich TC, Rakasz EG, Wilson NA, McDermott AB, Boyle R, Allison DB, Burton DR, Desrosiers RC, Koff WC, Watkins DI (2008). Macaques vaccinated with live-attenuated SIV control heterologous virus challenge. J Exp Med 205:2537-50.
  • Sacha JB, Reynolds MR, Buechler MB, Chung C, Jonas AK, Wallace LT, Weiler AM, Lee W, Piaskowski SM, Soma T, Friedrich TC, Wilson NA, Watkins DI (2008). Differential antigen presentation kinetics of CD8+ T cell epitopes derived from the same viral protein. J Virol 82:9293-8.
  • Maness NJ, Yant LJ, Chung C, Loffredo JT, Friedrich TC, Piaskowski SM, Furlott J, May GE, Soma T, León EJ, Wilson NA, Piontivska H, Hughes AL, Sidney J, Sette A, Watkins DI (2008). Comprehensive immunological evaluation of “elite” controller and progressor, Mamu-B*17-positive SIV-infected rhesus macaques reveals surprisingly few differences. J Virol 82:5245-54.
  • Weiler AM, Li Q, Duan L, Kaizu M, Weisgrau K, Friedrich TC, Reynolds MR, Haase AT, Rakasz EG (2008). Genital ulcers facilitate rapid viral entry and dissemination following intravaginal inoculation with cell-associated SIVmac239. J Virol 82:4154-8.
  • Loffredo JT, Bean AT, Beal DR, León EJ, May GE, Piaskowski SM, Furlott JR, Reed J, Musani SK, Rakasz EG, Friedrich TC, Wilson NA, Allison DB, Watkins DI (2008). Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control SIVmac239 replication. J Virol 82:1723-38.
  • Loffredo JT*, Friedrich TC*, León EJ, Stephany JJ, Rodrigues DS, Spencer SP, Bean AT, Beal DR, Burwitz BJ, Rudersdorf RA, Wallace LT, Piaskowski SM, May GE, Sidney J, Gostick E, Wilson NA, Price DA, Kallas EG, Piontivska H, Hughes AL, Sette A, Watkins DI (2007). CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation. PLoS ONE 2:e1152.
  • Maness NJ, Valentine LE, May GE, Reed J, Piaskowski SM, Soma T, Furlott J, Rakasz EG, Friedrich TC, Hughes AL, Sidney J, Sette A, Wilson NA, Watkins DI (2007). AIDS virus-specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape. J Exp Med 204:2505-12.
  • Sacha JB, Chung C, Reed J, Jonas AK, Bean AT, Spencer SP, Lee W, Vojnov L, Rudersdorf R, Friedrich TC, Wilson NA, Lifson JD, Watkins DI (2007). Pol-specific CD8+ T cells recognize simian immunodeficiency virus-infected cells prior to nef-mediated major histocompatibility complex class I downregulation. J Virol 81:11703-11712.
  • Friedrich TC, Valentine LE, Yant LJ, Rakasz EG, Piaskowski SM, Furlott JR, Weisgrau KL, Burwitz B, May GE, León EJ, Soma T, Napoe G, Capuano SV, Wilson NA, Watkins DI (2007). Subdominant CD8+ T cell responses are involved in durable control of AIDS virus replication. J Virol 81:3465-76.
  • Loffredo JT, Burwitz BJ, Rakasz EG, Spencer SP, Stephany JJ, Giraldo Vela JP, Martin SR, Reed, J, Piaskowski SM, Furlott J, Weisgrau KL, Rodrigues DS, Soma T, Napoe G, Friedrich TC, Wilson NA, Kallas EG, Watkins DI (2007). SIV-specific CD8+ T cell antiviral efficacy is unrelated to epitope specificity and is abrogated by viral escape. J Virol 81:2624-34.
  • Sacha JB, Chung C, Rakasz EG, Spencer SP, Jonas AK, Bean AT, Lee W, Burwitz B, Stephany J, Loffredo JT, Allison DB, Adnan A, Hoji A, Wilson N, Friedrich TC, Lifson JD, Yang OO, Watkins DI (2007). Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and protein expression. J Immunol 178:2746-54.
  • Chung C, Lee W, Loffredo JT, Burwitz B, Friedrich TC, Giraldo Vela JP, Napoe G, Rakasz EG, Wilson NA, Allison DB, Watkins DI (2007). Not all cytokine-producing CD8+ T-cells suppress simian immunodeficiency virus replication. J Virol 81:1571-23.
  • Wiseman RW, Wojechowskyj JA, Greene JM, Blasky AJ, Gopon T, Soma T, Friedrich TC, O’Connor SL, O’Connor DH (2007). SIVmac239 infection of MHC identical cynomolgus macaques from Mauritius. J Virol 81:349-61.
  • Kaizu M, Weiler AM, Weisgrau KL, Vielhuber KA, May G, Piaskowski SM, Furlott J, Maness NJ, Friedrich TC, Loffredo JT, Usborne A, Rakasz EG (2006). Repeated intravaginal inoculation with cell-associated simian immunodeficiency virus results in persistent infection of nonhuman primates. J Infect Dis 194:912-16.
  • Wilson NA, Reed J, Napoe GS, Piaskowski S, Szymanski A, Furlott J, Gonzalez EJ, Yant LJ, Maness NJ, May GE, Soma T, Reynolds MR, Rakasz E, Rudersdorf R, McDermott AB, O’Connor DH, Friedrich TC, Allison DB, Patki A, Picker LJ, Burton DR, Lin J, Huang L, Patel D, Heindecker G, Fan J, Citron M, Horton M, Wang F, Liang X, Shiver JW, Casimiro DR, Watkins DI (2006). Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239. J Virol 80:5875-85.
  • Yant LJ, Friedrich TC, Johnson RC, May GE, Maness NJ, Enz AM, Lifson JD, O’Connor DH, Carrington M, Watkins DI (2006). The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication. J Virol 80:5074-77.
  • Friedrich TC, McDermott AB, Reynolds MR, Piaskowski SM, Fuenger S, DeSouza IP, Rudersdorf R, Cullen C, Yant LJ, Vojnov L, Stephany J, Martin S, O’Connor DH, Wilson N, Watkins DI (2004). Consequences of CTL escape: common escape mutations in simian immunodeficiency virus are poorly recognized in naïve hosts. J Virol 78:10064-73.
  • Friedrich TC, Dodds EJ, Yant LJ, Vojnov L, Rudersdorf R, Cullen C, Evans DT, Desrosiers RC, Mothé BR, Sidney J, Sette A, Kunstman K, Wolinsky S, Piatak M, Lifson J, Wilson N, O’Connor DH, Watkins DI (2004). Reversion of cytotoxic T-lymphocyte (CTL) escape variant viruses in vivo. Nat Med 10:275-81.
  • Friedrich TC, Frye CA, Yant LJ, O’Connor DH, Kriewaldt NA, Benson ML, Vojnov L, Dodds EJ, Cullen C, Rudersdorf R, Hughes AL, Wilson N, Watkins DI (2004). Extra-epitopic compensatory substitutions restore fitness to simian immunodeficiency virus variants that escape from an immunodominant cytotoxic T-lymphocyte response. J Virol 78:2581-5.
  • Vogel TU*, Friedrich TC*, O’Connor DH, Rehrauer W, Horton H, Vielhuber K, Carter DK, Rudersdorf R, Allen TM, Wilson N, Watkins DI (2002). Escape in one of two cytotoxic T-lymphocyte epitopes bound by a high-frequency MHC class I molecule, Mamu-A*02: a paradigm for virus evolution and persistence? J Virol 76:11623-36.
  • Lee Y, Renaud RA, Friedrich TC, Gorski J (1998). Estrogen causes cell death of estrogen receptor stably transfected cells via apoptosis. J Steroid Biochem Mol Biol 67:327-32.
Invited publications
  • Johnson R, Yingyun C, Wahl-Johnson V, Fang Y, Friedrich TC, Radoshitzky SR, Kota K, O’Connor D, Bavari S, Jahrling PB, Goldberg TL, Kuhn JH (2011) Simian hemorrhagic fever virus as a model for risk group 4 pathogens. In: Proceedings of the 2nd International Conference on Fundamental and Applied Aspects of Medical Primatology, vol. 1. August 8-10, Sochi-Adler, Krasnodar Krai, Russia.
  • Friedrich TC and Watkins DI (2008) Wanted: Correlates of vaccine-induced protection against SIV. Curr Opin HIV AIDS 3:393-8.
  • Friedrich TC and Watkins DI (2005) The role of the SIV model in AIDS vaccine research. IAVI Rep. 9:6-8.
  • Friedrich TC and Watkins DI. Truth or consequences: understanding the functional significance of AIDS virus escape from immune responses. In: Proceedings of the Cent Gardes meeting organized by the Fondation Mérieux in partnership with Aventis Pasteur and with the participation of IAVI, Annecy (France), 27-29 October 2002 Marc Girard, Marissa Vicari, Betty Dodet (Eds.) Amsterdam: Elsevier, 2003.
  • Friedrich TC and Watkins DI. Influence of MHC gene products on immune control of AIDS virus infection: consideration for use in nonhuman-primate resources. In: International Perspectives: The future of nonhuman primate resources, proceedings of the workshop held April 17-19, 2002 John L. VandeBerg et al. (Eds.) Washington, DC: National Academies Press, 2002.
  • O’Connor D, Friedrich T, Hughes A, Allen TM, Watkins DI (2001) Understanding cytotoxic T-lymphocyte escape during simian immunodeficiency virus infection. Immunol Rev 183:115-26.