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Welcome to the web site of the Jyoti Watters Lab
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Our research focuses on delineating the role of
the MAP kinase pathways in controlling microglial cell production
of inflammatory mediators, and how hypoxia and hypoxia and reperfusion
injury modulate the activity of purinergic P2 receptors for extracellular
ATP and their signaling pathways. Selective alterations in the activity
of purinergic receptors may provide a novel therapeutic target that
can be exploited to minimize damage to the brain following ischemic
injury.
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Other goals of our research center on delineating
the anti-inflammatory effects of estrogen on microglial cell activation
at the molecular level, by dissecting the signal transduction pathways
and receptors that are modulated by estrogen in activated microglial
cells. Defining the molecular mechanisms involved in the estrogen
modulation of microglial cell activation and their production of
inflammatory mediators, may lead to the identification of novel
therapeutic targets that can be exploited to minimize the brain
damage ensuing from neurodegenerative diseases and other brain disorders,
to which women are predisposed.
Site Last Updated: 07/15/2008
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