to the Vezina Lab
lab uses the fetal mouse prostate as a model system to elucidate prostate
growth stimulatory and inhibitory signals and investigate interactions
between them in clinically relevant models of prostate disease. Our ultimate
goal is to identify new pharmacological targets for prostate disease intervention.
We are investigating how male hormones initiate prostate ductal formation,
how prostate ducts elongate into surrounding mesenchyme, and how both
of these processes are patterned in three dimensions to give rise to a
bilaterally symmetrical prostate gland comprised of anterior dorsal, lateral,
and ventral lobes. We test whether pharmacological agents disrupt these
normal processes of prostate development and whether they will also block
the abnormal processes contributing to prostate diseases in men.